Metabolites, Год журнала: 2024, Номер 14(12), С. 724 - 724
Опубликована: Дек. 22, 2024
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has spurred an extraordinary scientific effort to better understand disease’s pathophysiology and develop diagnostic prognostic tools guide more precise effective clinical management. Among biological samples analyzed for biomarker identification, urine stands out due its low risk of infection, non-invasive collection, suitability frequent, large-volume sampling. Integrating data from omics studies with standard biochemical analyses offers a deeper comprehensive understanding COVID-19. This review aims provide detailed summary published date that have applied on identify potential biomarkers In July 2024, advanced search was conducted in Web Science using query: “covid* (Topic) AND metabol* (Topic)”. included results up 14 October 2024. retrieved this digital were evaluated through two-step screening process: first reviewing titles abstracts eligibility, then retrieving assessing full texts articles met specific criteria. initial 913 studies, which 45 ultimately review. most robust identified include kynurenine, neopterin, total proteins, red blood cells, ACE2, citric acid, ketone bodies, hypoxanthine, amino acids, glucose. causes underlying these alterations reflect multisystemic impact COVID-19, highlighting key processes such as systemic inflammation, renal dysfunction, critical hypoxia, metabolic stress.
Язык: Английский