Dust exposure and its health implications to miners in Mererani artisanal and small-scale mining industry

International Journal of Environmental & Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 23

Опубликована: Янв. 9, 2025

This study aimed to identify and quantify the total dust exposure underground miners in Mererani, Tanzania, its composition generate evidence for informed decision- policy-making. The Analytical Air Monitoring System (AMS) was used collection, analysis conducted gravimetrically. analysed using Inductively Coupled Plasma Optical Emission Spectroscopy. results showed significant variation levels across different mining zones, with inhaling up 1859 mg of over an 8-hour period drilling zones (DZ), 797 loading (LZ), 382 resting (RZ). mean value significantly different, a p-value <0.05. Miners had higher heavy metal silica than those from unmined sites, chromium being most dominant element all samples. Cumulative time is linked long-term respiratory impairment serious health conditions such as lung cancer. These findings highlight need intervention, including education on hazards, provision personal protective equipment (PPE), enforcement safety standards safeguard miners' health. Addressing these issues critical promoting policy reforms sustainable practices Mererani similar communities.

Язык: Английский

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Silica dust exposure and associated pulmonary dysfunction among mine workers

Journal of Environmental Science and Health Part A, Год журнала: 2025, Номер unknown, С. 1 - 11

Опубликована: Фев. 28, 2025

This study assessed the impact of silica exposure on 145 mine workers in Mianwali, Punjab, Pakistan, compared to 45 non-exposed individuals. Pulmonary function tests revealed significantly reduced lung exposed (P < 0.05), with declines Forced Expiratory Volume one second (FEV1), Vital Capacity (FVC), FEV1/FVC ratio, Peak Flow, and Flow at 25-75% FVC (FEF25-75). Radiological evaluations confirmed extensive damage including pleural effusion, reticular shadowing, consolidation. Oxidative stress markers demonstrated increased lipid peroxidation, Fenton's Stress, Stress Index along antioxidant enzyme activities, Catalase, Superoxide Dismutase, Total Antioxidant Capacity, Glutathione Peroxidase. Hematological analysis showed elevated White Blood Cells, Lymphocyte percentage, Hemoglobin, Hematocrit, Mean Corpuscular Volume, Hemoglobin reflecting systemic inflammation. Silica's piezoelectric properties contributed oxidative cellular damage, exacerbating pulmonary dysfunction. These findings highlight as a severe occupational hazard, causing irreversible impairment imbalance. Implementing strict safety protocols, personal protective measures, regular health monitoring is crucial safeguarding workers.

Язык: Английский

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Fibrotic Hypersensitivity Pneumonitis: A Diagnostic Challenge Leading to Lung Transplantation

Diagnostics, Год журнала: 2025, Номер 15(10), С. 1267 - 1267

Опубликована: Май 16, 2025

Background/Objectives: Hypersensitivity pneumonitis (HP), a subtype of interstitial lung disease (ILD), is often misdiagnosed as idiopathic pulmonary fibrosis (IPF), particularly when the causative antigen cannot be identified. Typically resulting from chronic exposure to inhaled organic particles smaller than 5 microns, HP presents diagnostic challenge. This report outlines case fibrotic initially misclassified asthma. No triggering was identified despite extensive investigation. The progressed corticosteroid, immunosuppressive, and antifibrotic therapy, ultimately leading an advanced stage requiring transplantation. clinical course rare infrequently reported, in cases transplantation without identifiable antigen. Such progression uncommon underreported, especially patients having Methods: Medical records 24 diagnosed with were reviewed. Only one demonstrated HP; this selected for detailed analysis. Results: Clinical functional deterioration occurred standard therapy. Given treatment resistance, deemed next appropriate therapeutic option. Conclusions: remains underdiagnosed due difficulties identifying overlapping features other ILDs. Early accurate differentiation IPF essential, progressive forms unresponsive conventional therapies.

Язык: Английский

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Giant cell interstitial pneumonia: case series with comprehensive ultrastructural analyses of “not only” hard metal pneumoconiosis

Histopathology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

Aims Giant cell interstitial pneumonia (GIP) is a fibrosing lung disease histologically characterized by centrilobular pulmonary fibrosis and cannibalistic intra‐alveolar multinucleated giant cells. It considered form of pneumoconiosis caused particularly secondary exposure to hard metals (cemented carbide or tungsten carbide). Hard are commonly used in various industrial applications, such as cutting tools, drilling machine inserts, other wear‐resistant components. However, cases with unknown that recurred transplanted lungs have been described. This has led the hypothesis complex etiopathogenesis, likely multifactorial, involving coparticipation immune mechanisms. We aimed identify all elements present series GIP samples better understand pathogenic mechanisms disease. Methods Results describe five diagnosed patients occupational metallic dust using ultrastructural characterization metal quantify asbestos fibres. found was three cases, albeit trace amounts two them. Numerous were identified samples, including fibres endstage fibrosis. Furthermore, one described recurrence also observed lungs. Conclusion These findings support may be due than metals, possibly representing contributory factor expression more severe fibrotic The organs strengthens existence not yet fully understood etiopathogenic mechanism.

Язык: Английский

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