Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Дек. 28, 2024
Abstract
COVID-19
is
associated
with
long-term
cardiovascular
complications.
Heart
Rate
Variability
(HRV),
a
measure
of
sympathetic
(SNS)
and
parasympathetic
(PNS)
control,
has
been
shown
to
predict
outcomes
correlate
disease
progression
but
comprehensive
analysis
that
includes
demographic
influences
lacking.
The
objective
this
study
was
determine
the
balance
between
SNS,
PNS
heart
rhythm
regulation
in
hospitalized
patients
compare
it
similar
measurements
healthy
volunteers
individuals
diseases
(CVD),
while
also
investigating
effects
age,
Body
Mass
Index
(BMI),
gender
race.
Lead
I
ECG
recordings
were
acquired
from
50
patients,
31
volunteers,
51
(CVD)
without
COVID-19.
Fourteen
HRV
parameters
calculated,
including
time-domain,
frequency-domain,
nonlinear,
regularity
metrics.
population
included
balanced
profile,
55%
participants
being
under
65
years
54%
identifying
as
male,
68%
White.
Among
52%
had
BMI
≥
30
compared
29%
33%
CVD
patients.
exhibited
significantly
reduced
time-domain
parameters,
SDNN
RMSSD,
(SDNN:
0.02
±
s
vs.
0.06
0.03
s,
p
<
0.001;
RMSSD:
0.05
=
0.08).
In
frequency
domain,
both
showed
increased
low-frequency
(LF)
power
lower
high-frequency
(HF)
(COVID-19
LF:
18.47
18.18%,
HF:
13.69
25.80%;
Healthy
23.30
11.79%,
22.91
21.86%,
0.01).
LF/HF
ratio
(1.038
1.54)
(1.03
0.78).
Nonlinear
such
SD1
(0.04
0.04
0.08
0.01),
indicating
altered
autonomic
regulation.
Variations
observed
based
on
factors,
younger
females,
non-white
showing
more
pronounced
dysfunction.
exhibit
significant
alterations
HRV,
dysfunction,
characterized
by
decreased
vagal
tone
dominance,
severe
comorbidities.
Despite
higher
rates,
suggests
substantial
disruption
regulation,
particularly
specific
risk
factors.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(2), С. 378 - 378
Опубликована: Янв. 9, 2025
Long
COVID,
also
known
as
post-acute
sequelae
of
SARS-CoV-2
infection
(PASC),
is
increasingly
recognized
a
condition
affecting
not
only
adults
but
children
and
adolescents.
While
often
experience
milder
acute
COVID-19
symptoms
compared
to
adults,
some
develop
persistent
physical,
psychological,
neurological
lasting
for
weeks
or
months
after
initial
infection.
The
most
commonly
reported
include
debilitating
fatigue,
respiratory
issues,
headaches,
muscle
pain,
gastrointestinal
disturbances,
cognitive
difficulties,
which
significantly
impact
daily
activities,
schooling,
social
interactions.
Additionally,
many
with
long
COVID
psychological
symptoms,
such
anxiety,
depression,
mood
swings,
irritability,
likely
exacerbated
by
prolonged
illness
lifestyle
disruptions.
Risk
factors
in
pre-existing
health
conditions
asthma,
obesity,
disorders,
adolescents
females
seemingly
more
affected.
Hypothesized
mechanisms
underlying
chronic
immune
dysregulation,
viral
particles
stimulating
inflammation,
autonomic
nervous
system
dysfunction,
mitochondrial
impairment,
may
collectively
contribute
the
variety
observed
symptoms.
Long-term
outcomes
remain
uncertain;
however,
can
lead
school
absenteeism,
withdrawal,
distress,
potentially
development.
Severe
cases
postural
orthostatic
tachycardia
syndrome
(POTS)
reduced
exercise
tolerance.
This
review
synthesizes
existing
literature
on
children,
examining
its
prevalence,
symptomatology,
risk
factors,
potential
mechanisms,
an
emphasis
need
further
clinical
studies.
research
largely
relies
surveys
self-reported
data,
assessments
are
essential
accurately
characterize
pediatric
populations
guide
effective
management
strategies.
The Pediatric Infectious Disease Journal,
Год журнала:
2024,
Номер
43(8), С. 795 - 802
Опубликована: Май 7, 2024
Background:
Cardiopulmonary
exercise
testing
(CPET)
is
a
noninvasive
and
nonexpensive
diagnostic
tool,
that
provides
comprehensive
evaluation
of
the
pulmonary,
cardiovascular,
skeletal
muscle
systems’
integrated
reactions
to
exercise.
CPET
has
been
extensively
used
in
adults
with
Long
COVID
(LC),
while
evidence
about
its
role
children
this
condition
scarce.
Methods:
Prospective,
case-controlled
observational
study.
Children
LC
control
group
healthy
underwent
CPET.
findings
were
compared
within
2
groups,
groups
according
main
clusters
persisting
symptoms.
Results:
Sixty-one
29
controls
included.
Overall,
90.2%
patients
(55
61)
had
pathologic
test
vs
10.3%
(3/29)
control.
presented
statistically
significant
higher
probability
having
abnormal
values
peak
VO2
(
P
=
0.001),
AT%
pred
<0.001),
VO2/HR
%
0.03),
work
slope
0.002),
VE/VCO2
0.01).
The
mean
was
30.17
(±6.85)
34.37
(±6.55)
0.007).
Conclusions:
Compared
controls,
have
objective
impaired
functional
capacity
(expressed
by
low
peak),
signs
deconditioning
cardiogenic
inefficiency
when
assessed
As
such,
should
be
routinely
clinical
practice
objectify
phenotype
limitations
LC,
follow-up
them.
Journal of microbiology epidemiology immunobiology,
Год журнала:
2025,
Номер
102(1), С. 43 - 61
Опубликована: Март 30, 2025
Background.
Data
on
the
prevalence
of
post-COVID-19
condition
(PCC)
in
children
differ
due
to
lack
specific
diagnostic
criteria,
reliable
biomarkers,
and
limitations
many
studies.
It
is
important
study
association
between
PCC,
previous
functional
disorders,
any
events
post-acute
period
COVID-19
estimate
true
burden
PCC
children.
The
aim.
To
determine
relation
initial
disorders
during
year
after
a
mild
form
acute
respiratory
tract
infections
(ARTI)
other
etiologies.
Materials
methods.
prospective
using
continuous
sampling
method
included
under
18
years
age
hospitalized
with
suspected
COVID-19,
whom
was
confirmed
by
RT-PCR
(n
=
121)
or
excluded
molecular
serological
methods
(ARTI
group,
n
105).
Information
patients
collected
from
September
2020
December
2021
questionnaires
at
index
points:
hospital
discharge
1,
3,
6
12
months.
Severe
chronic
diseases
were
excluded.
Functional
anamnesis
associated
health
observation,
severity
symptoms
taken
into
account.
analysis
performed
groups
≥
age.
Symptoms
grouped
clusters.
Results.
Any
identified
frequency
32–39%
(in
≥6
years,
respectively).
most
common
psycho-emotional,
autonomic
dysfunction
(AD)
cluster.
cases
duration
3–6
After
adjustment
for
age,
AD
history
recurrent
ARTI
episodes,
no
difference
found
symptom
clusters
except
hyposmia,
incidence
which
decreased
14.3%
first
point
2.4%
one
year.
Among
without
an
year,
de
novo
rare
phenomenon
(2.7–8.0%)
differences
controls.
risks
significantly
increased
(adjusted
OR
1
month
3.19
(95%
CI
1.89–5.38),
months
3.33
1.81–6.15)).
Multiple
(5–25)
persistent
(at
all
points)
rated
as
significant
occurred
rarely
(1.7%
0.4–4.9)),
but
more
often
—
25%)
95%
13.6–39.6%)
(difference
23.3%
(10.9–35.7%),
14.8
(4.4–50.6),
p
0.001).
Recurrent
episodes
risk
factor
increase
cognitive
cluster
complaints
vagotonic
observation.
Conclusion.
results
obtained
indirectly
support
concept
that
somatoform
disorder,
probably
sociogenic
nature,
who
are
anxious
baseline.
Some
consequences
really
need
medical
psychosocial
rehabilitation.
provides
new
insights
widespread
viral
infections.
Acta Paediatrica,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 13, 2025
ABSTRACT
Aim
To
identify
the
symptom
burden
in
children
and
adolescents
with
post
COVID‐19,
a
validated
reliable
instrument
is
needed,
particularly
to
assess
symptoms
their
impact
on
child.
The
aim
of
this
study
was
describe
development,
validation,
reliability
Post
COVID‐19
Kids
Questionnaire
(POCOKIDS‐Q),
which
designed
adolescents.
Methods
POCOKIDS‐Q
developed
based
literature,
clinical
experience,
questionnaires
for
adults
COVID‐19.
linguistic
validation
involved
9‐
17‐year‐old
children.
Children
onset
were
asked
complete
final
version
through
web
link.
Exploratory
confirmatory
factor
analyses
performed
structure
that
explains
covariances
between
variables.
Results
link
opened
324
times
fully
completed
by
213
(66%)
young
(median
age
14
years)
symptoms.
Confirmatory
revealed
four
significant
correlated
factors:
brain
fatigue,
cognitive
impact,
physical
emotional
impact.
explanatory
power
model
high.
Conclusion
applicable
assessing
adults.
Open Forum Infectious Diseases,
Год журнала:
2024,
Номер
11(9)
Опубликована: Авг. 27, 2024
Abstract
While
the
acute
manifestations
of
infectious
diseases
are
well
known,
in
some
individuals,
symptoms
can
either
persist
or
appear
after
period.
Postviral
fatigue
syndromes
recognized
with
other
viral
infections
and
described
coronavirus
disease
2019
(COVID-19).
We
have
a
growing
number
individuals
that
for
weeks,
months,
years.
Here,
we
share
evidence
regarding
abnormalities
associated
postacute
sequelae
COVID-19
(PASC)
therapeutics.
describe
physiological
biochemical
seen
reporting
PASC.
several
evidence-based
interventions
to
offer
patients.
It
is
expected
this
understanding
mechanisms
driving
PASC
benefits
certain
therapeutics
may
not
only
lead
better
outcomes
those
but
also
potential
treating
postinfectious
sequelae.
Pediatric Pulmonology,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 16, 2024
Abstract
This
systematic
review
aimed
to
investigate
the
prevalence
of
symptoms
post‐COVID‐19
condition
(long
COVID),
in
children
hospitalized
with
COVID‐19.
We
searched
PUBMED
and
EMBASE
on
15
March,
2023,
using
search
strategy:
“long
COVID”
OR
“post‐COVID‐19”
“postacute
COVID‐19”
“long‐term
“COVID‐19
sequelae”
“persistent
“chronic
COVID‐19”.
included
observational
studies
(case‐control,
cross‐sectional,
cohort,
or
case
series)
that
investigated
COVID)
(<18
years)
admitted
used
WHO
definition
condition.
Long
COVID
was
defined
as
persistence
otherwise
unexplained
for
at
least
three
months
after
SARS‐CoV‐2
infection.
command
“metaprop”
perform
random‐effects
meta‐analysis.
Eleven
involving
2279
patients
were
included.
In
period
between
≥3
<12
acute
COVID‐19,
most
frequent
symptom
exercise
intolerance
a
pooled
29%
(95%
CI:
7%–57%,
I
2
=
95%),
followed
by
nonspecific
respiratory
(12%,
95%
0%–48%,
0%),
psychological
disorders
(10%,
1%–25%,
97%),
gastrointestinal
0%–37%,
99%).
≥12
initial
infection,
post
lower,
6%
2%–10%,
83%)
3%
0%–8%,
89%)
fatigue.
conclusion,
post‐COVID
affect
multiple
organ
systems,
higher
up
12
phase
