Association between total testosterone and cervical cancer: A bidirectional Mendelian randomization study DOI Creative Commons
Qiongying Lyu, Juan Zhang,

Xiaoyan He

и другие.

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Ноя. 9, 2023

Abstract Background Several experimental studies already proved that the increase of total testosterone could lead to development gynecological disease. Animal experiments have shown may be associated with progression cervical cancer (CC). And metabolism cholesterol which serves as initial raw material for synthesis is crucial occurrence CC. However, causal relationship between CC and Total still remained unknown. Methods We performed bidirectional Mendelian randomization (MR) study using summary statistics from genome-wide association (GWAS) Single nucleotide polymorphisms (SNPs) were used instrumental variables (IVs) GWAS in this study. The random-effects inverse-variance weighted (IVW) estimation method was applied primary several other estimators complementary methods. seen exposure forward MR analysis utilized reverse analysis, their SNPs read screened by "TwoSampleMR" R package. results verified a series sensitive analyses. Moreover, Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment genes regulated variable conducted “cluster Profiler”. Results In our study, (OR:1.0016, 95% confidence interval [CI]: 1.0005–1.0027; p < 0.05) clarified these effectively predict increases risk CC, indicating direct effect on IVW did not find significant (p = 0.557). MR, most are mainly involved C21-steroid hormone metabolic process, MHC protein complex progesterone signal pathways Th1 Th2 cell differentiation, Hematopoietic lineage, Th17 differentiation. Conclusion present strengthened evidence potential factor Whether affects needs further research.

Язык: Английский

Cannabis Use and Head and Neck Cancer DOI
Tyler J. Gallagher, Ryan S. Chung, Matthew E. Lin

и другие.

JAMA Otolaryngology–Head & Neck Surgery, Год журнала: 2024, Номер unknown

Опубликована: Авг. 8, 2024

Cannabis is the most commonly used illicit substance worldwide. Whether cannabis use associated with head and neck cancer (HNC) unclear.

Язык: Английский

Процитировано

19
Relationship between bullous pemphigoid and malignancy: A Mendelian randomization study DOI Creative Commons
Mingjie He,

Yu‐Jia Wang,

De-long Ran

и другие.

The Journal of Dermatology, Год журнала: 2024, Номер 51(3), С. 403 - 408

Опубликована: Янв. 11, 2024

Bullous pemphigoid (BP) is the most common autoimmune blistering disease, which primarily affects elderly. However, relationship between BP and malignancy remains controversial in traditional observational studies. The aim of this study, included only European populations, was to assess potential causative link 13 types malignant tumors a two-sample Mendelian randomization (MR) study. not associated with an increased risk developing tumors. This study did find causal further research warranted examine generalizability conclusion non-European populations.

Язык: Английский

Процитировано

5
Cannabinoids and triple-negative breast cancer treatment DOI Creative Commons

Luka Dobovišek,

Simona Borštnar, Nataša Debeljak

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Авг. 8, 2024

Triple-negative breast cancer (TNBC) accounts for about 10-20% of all cases and is associated with an unfavorable prognosis. Until recently, treatment options TNBC were limited to chemotherapy. A new successful systemic immunotherapy immune checkpoint inhibitors, but tumor-specific biomarkers are needed improve patient outcomes. Cannabinoids show antitumor activity in most preclinical studies models do not appear have adverse effects on Clinical data evaluate efficacy safety humans. Importantly, the endocannabinoid system linked immunosuppression. Therefore, cannabinoid receptors could be a potential biomarker inhibitor therapy or novel mechanism reverse resistance immunotherapy. In this article, we provide overview currently available information how cannabinoids may influence standard TNBC.

Язык: Английский

Процитировано

5
Identification of SUMOylation biomarkers in glioblastoma based on transcriptome and Mendelian randomization combined with single-cell RNA-seq analysis DOI Creative Commons
Xiaodong Shao, Shun Yao,

Junjie Dai

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Abstract Aberrant SUMOylation has been associated with cancer, neurodegenerative diseases, and infections, but its exact role in glioblastoma (GBM) remains unknown. This study aimed to uncover this link identify novel biomarkers for GBM treatment. NPC2, SPI1, LRRC25 were identified as prognostic outcomes. MR analysis showed that NPC2 increased risk, while SPI1 had a protective effect. A nomogram effectively predicted prognosis. These enriched pathways such allograft rejection, inflammatory response, IL6-JAK-STAT3 signaling. Significant immune differences found between normal groups, correlating M2 macrophages activated NK cells, HAVCR2. expressed actively propagating macrophages, dendritic consistently up regulated datasets. findings suggest are SUMOylation-related GBM, offering potential therapeutic targets.

Язык: Английский

Процитировано

0
WITHDRAWN: Identification of SUMOylation biomarkers in glioblastoma based on transcriptome and Mendelian randomization combined with single-cell RNA-seq analysis DOI
Xiaodong Shao, Shun Yao,

Junjie Dai

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 6, 2025

Abstract The full text of this preprint has been withdrawn by the authors while they make corrections to work. Therefore, do not wish work be cited as a reference. Questions should directed corresponding author.

Язык: Английский

Процитировано

0
The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside DOI Creative Commons
Xin Jin,

C. Huang,

Yue Tian

и другие.

Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Июль 3, 2024

Despite being characterized by high malignancy, morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC) has not been fully elucidated. Ferroptosis, a non-apoptotic form regulated cell death, possesses distinct morphological, biochemical, genetic characteristics compared to other types death. Dysregulated actions within molecular network that regulates ferroptosis have identified as significant contributors progression HCC. Long non-coding RNAs (lncRNAs) emerged influential diverse cellular processes, regulating gene function expression through multiple mechanistic pathways. An increasing body evidence indicates deregulated lncRNAs are implicated in malignant events such proliferation, growth, invasion, metabolism influencing Therefore, elucidating inherent role modulatory functions on HCC might promote development novel therapeutic interventions for this disease. This review provides succinct overview roles ferroptosis-related treatment, aiming drive promising targets biomarkers patients.

Язык: Английский

Процитировано

2
Strategies for treating the cold tumors of cholangiocarcinoma: core concepts and future directions DOI Creative Commons

GuanBo Zhang,

Jinsong Li, Gang Li

и другие.

Clinical and Experimental Medicine, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 14, 2024

Cholangiocarcinoma (CCA) is a rare type of digestive tract cancer originating from the epithelial cells liver and biliary tract. Current treatment modalities for CCA, such as chemotherapy radiation therapy, have demonstrated limited efficacy in enhancing survival rates. Despite revolutionary potential immunotherapy management, its application CCA remains restricted due to minimal infiltration immune these tumors, rendering them cold unresponsive checkpoint inhibitors (ICIs). Cancer within tumors deploy various mechanisms evading attack, thus impeding clinical management. Recently, combination has become increasingly essential comprehend underlying enhance deficient antitumor response. Therefore, thorough understanding knowledge on imperative leverage benefits treating patients. Moreover, gut microbiota plays an role immunotherapeutic responses CCA. In this review, we summarize current concepts clarify intricate dynamics tumor microenvironment (TIME) We also delve into evasion employed by against anti-tumor responses. The context immunotherapies igniting critical function prompting been annotated. Furthermore, proposed future directions realm immunotherapy, aiming improve prognosis

Язык: Английский

Процитировано

2
Unveiling the pathological functions of SOCS in colorectal cancer: current concepts and future perspectives DOI
Yuhan Wang, Sha Wu,

ZhiHui Song

и другие.

Pathology - Research and Practice, Год журнала: 2024, Номер 262, С. 155564 - 155564

Опубликована: Авг. 28, 2024

Язык: Английский

Процитировано

2
Causal relationship between complement C1QB and colorectal cancer: a drug target Mendelian randomization study DOI Creative Commons
Mingwen Jiao, Yuying Cui,

Xiaodong Qiu

и другие.

Frontiers in Genetics, Год журнала: 2024, Номер 15

Опубликована: Июль 23, 2024

Background Colorectal cancer is influenced by several factors such as unhealthy habits and genetic factors. C1QB has been linked to a number of malignancies. However, uncertainty surrounds the connection between CRC. Therefore, this study aimed explore bidirectional causal relationship drug target in CRC through Mendelian randomization (MR) analysis. Methods The GWASs for were obtained from Integrative Epidemiology Unit Open GWAS database. There five strategies investigate MR. Sensitivity analysis was carried out via tests heterogeneity, horizontal pleiotropy leave-one-out effects evaluate dependability MR results. Furthermore, colocalization CRC, protein-protein interaction network prediction according exposure well phenotype scanning performed. Results results forward demonstrated that risk factor (OR = 1.104, p 0.033). we did not find (reverse MR). Rs294180 rs291985 corresponded same linkage interval had potential influence respectively. PPI interacted with 10 genes ( C1QA , C1QC C1R C1S C2 C4A C4B CALR SERPING1 VSIG4 ). Additionally, 21 medications predicted match . Molecular docking data, including benzo(a)pyrene, 1-naphthylisothiocyanate, calcitriol medroxyprogesterone acetate, revealed excellent binding drugs proteins. Moreover, identified 29 diseases associated related medicines disease intersection methods. As therapeutic phenotypic does significantly affect weight loss, liver cirrhosis, or nonalcoholic fatty disease, but might have protective impacts on ovarian melanoma. Conclusion highlight imply an oncogenic role targets. Drugs designed greater chance success clinical trials are expected help prioritize development reduce costs. That provided theoretical foundation reference research

Язык: Английский

Процитировано

1
Transcriptome sequencing and Mendelian randomization analysis identified biomarkers related to neutrophil extracellular traps in diabetic retinopathy DOI Creative Commons

Linlin Hao,

Songhong Wang,

Lian Zhang

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Окт. 17, 2024

In the development of diabetic retinopathy (DR), neutrophil infiltration hastens adhesion between neutrophils and endothelial cells, leading to inflammation. Meanwhile, extracellular traps (NETs) produced by could clear aging blood vessels, setting stage for retinal vascular regeneration. To explore mechanism NETs-related genes in DR, transcriptome NETs from normal DR individuals were analyzed with gene sequencing mendelian randomization (MR) analysis. Five identified as key genes. Among these genes, CLIC3, GBP2, P2RY12 found be risk factors Proliferative DR(PDR), whereas HOXA1 PSAP protective factors. Further verification qRT-PCR recognized NETs-associated biomarkers PDR.

Язык: Английский

Процитировано

1