Emerging patterns in rodent-borne zoonotic diseases

Science, Год журнала: 2024, Номер 385(6715), С. 1305 - 1310

Опубликована: Сен. 19, 2024

Rodents are ubiquitous and typically unwelcome dwellers in human habitats worldwide, infesting homes, farm fields, agricultural stores potentially shedding disease-causing microbes into the most human-occupied of spaces. Of vertebrate animal taxa that share pathogens with us, rodents abundant diverse, hundreds species confirmed zoonotic hosts, some which have nearly global distributions. However, only 12% rodent known to be sources also infect people, those do now recognized as tending a suite predictable traits. Here, we characterize traits explore them context three emerging or reemerging rodent-borne diseases people: Lassa fever, Lyme disease, plague.

Язык: Английский

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Zoonotic Tick‐Borne Pathogens in Ixodes ricinus Complex (Acari: Ixodidae) From Urban and Peri‐Urban Areas of Kosovo

Zoonoses and Public Health, Год журнала: 2024, Номер unknown

Опубликована: Дек. 8, 2024

ABSTRACT Introduction Ixodes ricinus , the castor bean tick, is most prevalent tick species in Europe. It favours habitats such as shrubs, deciduous and mixed forests, but can also be found urban environments. Due to its high vector competence, it of enormous veterinary well medical importance, transmitting tick‐borne encephalitis (TBE) virus, Borrelia burgdorferi s. l., causative agent lyme borreliosis, Rickettsia spp. Anaplasma phagocytophilum amongst many other pathogens. In Kosovo, I. predominant a few studies, mostly based on human animal seroprevalences, indicate circulation However, data pathogens are scarce particularly settings. This study aimed provide first insights into tic‐kborne from peri‐urban areas Kosovo. Methods Urban were sampled by flagging 150 m transects. total, 197 ticks morphologicaly identified consequently DNA RNA isolated. All individuals screened for presence using reverse line blotting (RLB) hybridisation. Results nine different four genera including spp., Babesia was detected 60 (33.5%) specimens. The frequently (16.2%), followed (11.7%). Altogether, 54 single infections, 11 double infections 1 triple infection observed. Conclusions We genotyping B. sensu lato detection this country. underline that recreational (peri‐)urban could facilitate spillover zoonotic humans Kosovo baseline future surveys.

Язык: Английский

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Global risk assessment of Lyme borreliosis transmission

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 29, 2025

ABSTRACT We analysed the geographic risk of Lyme borreliosis taking into account biogeography tick vectors and carrier hosts, together with environmental anthropogenic factors. Four pathogeographical scenarios were set in order to represent contribution hosts spatial zoonotic risk. For that propose, we built distribution models based on occurrence cases humans ixodid vectors. Besides Ixodes species, considered other ticks potential be These combined through fuzzy logic operators, according criteria stablished each scenario. Finally, transmission model for which best fitted its global was selected. The selected mammal carriers as explanatory variables environment species contributed explain geographical larger extent than ticks. described regions where presence is still uncertain, such northern Africa inland areas western USA. Likewise, our indicated favourable conditions human latitudes beyond endemic distribution. Applying this multi-scenario methodology approach have led us a model, diversity might modify without limitation.

Язык: Английский

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Molecular Typing of Tick-Borne Pathogens in Ixodids of Bosnia and Herzegovina

Microorganisms, Год журнала: 2025, Номер 13(5), С. 1054 - 1054

Опубликована: Апрель 30, 2025

Ticks are key vectors of zoonotic pathogens, and their expanding distribution in Europe heightens public health concerns. In Bosnia Herzegovina, while tick is well documented, molecular data on tick-borne pathogens remain limited. This study aimed to illustrate the presence diversity these focusing areas with high human activity. (n = 556) were collected April 2022 from eight diverse locations, including urban parks, private properties, rural sites. PCR-based screening was employed detect Anaplasmataceae, Borrelia, Francisella, Piroplasmida, Rickettsia, encephalitis virus (TBEV), subsequent sequencing confirm results. Further characterization Borrelia burgdorferi sensu lato achieved via reverse line blotting (RLB) hybridization sequencing. Ixodes ricinus most prevalent species, followed by Dermacentor marginatus D. reticulatus. Our analysis revealed an overall infection rate 22.1% questing ticks, Rickettsia spp. predominating. Notably, seven species identified I. ricinus, alongside Anaplasma phagocytophilum, helvetica, R. monacensis, co-infections mainly observed peri-urban areas. provides first evidence multiple region, underscoring need for further surveillance risk assessment diseases region.

Язык: Английский

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Prediction of the incidence of lyme disease using mathematical modeling methods (using the example of the Kirov region)

Journal of microbiology epidemiology immunobiology, Год журнала: 2025, Номер 102(2), С. 179 - 189

Опубликована: Май 12, 2025

Introduction. The Kirov region is an endemic for Lyme disease (ixodic tick-borne borreliosis), which caused by climatic conditions, abundance of ticks and their feeders. economic damage includes the cost treating patients eliminating natural foci. Morbidity forecasting necessary planning preventive measures (acaricide treatments, awareness-raising activities with population) entomological monitoring. effectiveness such exceeds above costs, underlines relevance study. aim study to analyze influence various factors on incidence using mathematical modeling methods further epidemiological example region. Materials methods. data state reports «On sanitary welfare population in region» 2006–2023 disease, first last reported cases tick attachment humans volume acaricide treatments were studied. Hydrometeorological data: monthly annual averages air temperature, humidity, precipitation. Spearman correlation analysis multiple regression performed «Excel MS Office-2021» «Statistica Advanced 12 Windows RU» software. level p 0.05 was chosen as a criterion statistical significance. Results. interval forecast up 18.67 2024, 16.51 2025, 14.36 per 100,000 2026. Correlations between morbidity have been identified. A negative reliable moderate density revealed treatments. Two models developed: based timing bites; hydrometeorological treatment. Conclusion. characterized downward trend. Mathematical predicting are proposed.

Язык: Английский

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Hazard potential of Swiss Ixodes ricinus ticks: Virome composition and presence of selected bacterial and protozoan pathogens

PLoS ONE, Год журнала: 2023, Номер 18(11), С. e0290942 - e0290942

Опубликована: Ноя. 13, 2023

Ticks play an important role in transmitting many different emerging zoonotic pathogens that pose a significant threat to human and animal health. In Switzerland abroad, the number of tick-borne diseases, particular encephalitis (TBE), has been increasing over last few years. Thus, it remains essential investigate pathogen spectrum ticks rapidly detect initiate necessary measures. To assess risk diseases regions Switzerland, we collected total 10’286 from rural urban areas ten cantons 2021 2022. were pooled according species, developmental stage, gender, collection site, analyzed using next generation sequencing (NGS) quantitative polymerase chain reaction (qPCR). The metagenomic analysis revealed for first time presence Alongshan virus (ALSV) Swiss ticks. Interestingly, pool-prevalence ALSV was higher than (TBEV). Furthermore, several TBEV foci have identified pool prevalence selected non-viral determined.

Язык: Английский

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Predictive Model of Lyme Disease Epidemic Process Using Machine Learning Approach

Applied Sciences, Год журнала: 2022, Номер 12(9), С. 4282 - 4282

Опубликована: Апрель 23, 2022

Lyme disease is the most prevalent tick-borne in Eastern Europe. This study focuses on development of a machine learning model based neural network for predicting dynamics epidemic process. A retrospective analysis cases reported Kharkiv region, East Ukraine, between 2010 and 2017 was performed. To develop process, multilayered used, backpropagation algorithm or generalized delta rule used its learning. The adequacy constructed forecast tested real statistical data incidence disease. took 22.14 s, mean absolute percentage error 3.79%. software package prediction basis has been developed. Results simulation have shown an unstable epidemiological situation disease, which requires preventive measures at both population level individual protection. Forecasting particular importance conditions hostilities that are currently taking place including endemic territories.

Язык: Английский

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Is Borrelia burgdorferi Sensu Stricto in South America? First Molecular Evidence of Its Presence in Colombia

Tropical Medicine and Infectious Disease, Год журнала: 2022, Номер 7(12), С. 428 - 428

Опубликована: Дек. 11, 2022

The genus

Язык: Английский

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Spatial and Temporal Variability in Prevalence Rates of Members of the Borrelia burgdorferi Species Complex in Ixodes ricinus Ticks in Urban, Agricultural and Sylvatic Habitats in Slovakia

Microorganisms, Год журнала: 2023, Номер 11(7), С. 1666 - 1666

Опубликована: Июнь 27, 2023

Lyme borreliosis (LB) is the most prevalent tick-borne human infection in Europe, with increasing incidence during latest decades. Abundant populations of Ixodes ricinus, main vector causative agent, spirochetes from Borrelia burgdorferi sensu lato (Bbsl) complex, have been observed urban and suburban areas general, Slovakia, particularly. Understanding spread infectious diseases crucial for implementing effective control measures. Global changes affect contact rates humans animals Borrelia-infected ticks increase risk contracting LB. The aim this study was to investigate spatial temporal variation prevalence Bbsl diversity its species questing I. ricinus three sites representing urban/suburban, natural agricultural habitat types Slovakia. nymphs adults were collected by dragging vegetation green Bratislava town (urban/suburban habitat), Small Carpathians Mountains (natural habitat) (south-western Slovakia) an at Rozhanovce eastern presence detected PCR identified restriction fragment length polymorphism (RFLP). s.l. coinfected reverse line blot. Significant variability infected revealed explored habitats. lowest total urban/suburban habitat, whereas higher found habitat. Six RFLP each type -B. stricto (s.s.), B. afzelii, garinii, valaisiana, lusitaniae spielmanii. Coinfections accounted 3% infections, whereby kurtenbachii RLB sequencing mixed s.s, garinii valaisiana. This finding represents first record Slovakia Europe. Variations proportion between adults, years types. Spatial variations patterns also confirmed locations within a relatively short distance Habitat-related distribution are probably associated local environmental conditions vertebrate host spectrum. Due pathogenic humans, all can be ranked as high epidemiological risk.

Язык: Английский

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Tick-Borne Encephalitis Virus and Borrelia burgdorferi Seroprevalence in Balkan Tick-Infested Individuals: A Two-Centre Study

Pathogens, Год журнала: 2023, Номер 12(7), С. 922 - 922

Опубликована: Июль 9, 2023

Lyme borreliosis (LB) and tick-borne encephalitis (TBE) are important diseases in Europe. This study aimed to investigate the seroreactivity against Borrelia burgdorferi TBE virus (TBEV) tick-infested individuals North Macedonia Serbia. Serum samples were collected from healthy same regions. Samples tested for anti-Borrelia IgG reactivity TBEV-neutralizing antibodies. Results showed higher antigens patients donors Novi Sad compared those Skopje region. However, there was no statistically significant difference between within each No antibodies detected participants or control groups, except one person who had a moderate reaction. The highlights need improved surveillance diagnostic capabilities LB these It also suggests potential existence of TBEV foci Macedonia. findings provide complementary understanding epidemiology studied regions; however, further research is needed presence distribution spp. ticks assess significance seroreactivity.

Язык: Английский

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