Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States

International Journal of Molecular Sciences, Год журнала: 2019, Номер 20(13), С. 3130 - 3130

Опубликована: Июнь 26, 2019

Chronic pain is a condition in which progresses from an acute to chronic state and persists beyond the healing process. impairs function decreases patients’ quality of life. In recent years, efforts have been made deepen our understanding develop better treatments alleviate pain. this review, we summarize results previous studies, focusing on mechanisms underlying development identification neural areas related We review association between negative affective states. Further, describe structural functional changes brain structures that accompany chronification discuss various neurotransmitter families involved. Our aims provide guidance for future therapeutic approaches could be used management

Язык: Английский

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Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents

Journal of Dermatological Science, Год журнала: 2021, Номер 102(3), С. 142 - 157

Опубликована: Май 2, 2021

Язык: Английский

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Somatosensory and autonomic neuronal regulation of the immune response

Nature reviews. Neuroscience, Год журнала: 2022, Номер 23(3), С. 157 - 171

Опубликована: Янв. 7, 2022

Язык: Английский

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Low back pain and osteoarthritis pain: a perspective of estrogen

Bone Research, Год журнала: 2023, Номер 11(1)

Опубликована: Авг. 4, 2023

Abstract Low back pain (LBP) is the world’s leading cause of disability and increasing in prevalence more rapidly than any other condition. Intervertebral disc (IVD) degeneration facet joint osteoarthritis (FJOA) are two common causes LBP, both occur frequently elderly women populations. Moreover, (OA) OA pain, regardless joint, experienced by up to twice as many men, this difference amplified during menopause. Changes estrogen may be an important contributor these states. Receptors for have been found within IVD tissue nearby joints, highlighting potential roles surrounding IVDs joints. In addition, supplementation has shown effective at ameliorating progression, indicating its use a therapeutic agent people with LBP pain. This review comprehensively examines relationship between conditions summarizing recent preclinical clinical findings. The molecular mechanisms which relieve associated FJOA discussed.

Язык: Английский

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Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic

Frontiers in Neuroscience, Год журнала: 2019, Номер 13

Опубликована: Ноя. 20, 2019

Tachykinins (TKs) are ancient neuropeptides present throughout the bilaterians and are, with some exceptions, characterized by a conserved FX1GX2Ramide carboxy terminus among protostomes FXGLMamide in deuterostomes. The best-known TK is vertebrate substance P, which mammals, together other TKs, has been implicated health disease important roles pain, inflammation, cancer, depressive disorder, immune system, gut function, hematopoiesis, sensory processing, hormone regulation. invertebrate TKs also known to have multiple functions central nervous system intestine these investigated more detail fly Drosophila arthropods. Here, we review protostome deuterostome organization evolution of precursors, peptides their receptors, as well functions, appear be partly across Bilateria. We outline distribution brains representative organisms. In Drosophila, recent studies revealed early olfactory neuromodulation circuits controlling locomotion food search, nociception, aggression, metabolic stress, release. signaling regulates lipid metabolism intestine. crustaceans, an neuromodulator rhythm-generating motor stomatogastric presynaptic modulator photoreceptor cells. Several additional functional can inferred from various brain circuits. addition, there few interesting cases where injected into prey animals vasodilators salivary glands or paralyzing agents venom glands. cases, produced predator sequences mimicking TKs. Lastly, TK-signaling appears duplicated Panarthropoda (comprising arthropods, onychophores, tardigrades) give rise novel type peptides, natalisins, distinct receptor. natalisins general, it that widely distributed act at short range neuromodulators cotransmitters.

Язык: Английский

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Current herbal medicine as an alternative treatment in dentistry: In vitro, in vivo and clinical studies

European Journal of Pharmacology, Год журнала: 2020, Номер 889, С. 173665 - 173665

Опубликована: Окт. 22, 2020

Язык: Английский

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Intra-CSF AAV9 and AAVrh10 Administration in Nonhuman Primates: Promising Routes and Vectors for Which Neurological Diseases?

Molecular Therapy — Methods & Clinical Development, Год журнала: 2020, Номер 17, С. 771 - 784

Опубликована: Апрель 11, 2020

The identification of the most efficient method for whole central nervous system targeting that is translatable to humans and safest route adeno-associated virus (AAV) administration a major concern future applications in clinics. Additionally, as many AAV serotypes were identified gene introduction into brain spinal cord, another key human gene-therapy success determine serotype. In this study, we compared lumbar intrathecal through catheter implantation intracerebroventricular cynomolgus macaque. We also evaluated two are currently used clinical trials: AAV9 AAVrh10. demonstrated delivery using achieved consistent transgene expression motor neurons cord neurons/glial cells several regions, whereas led brain. contrast, AAVrh10 rare neuron targeting. Finally, found efficiently targets respiratory skeletal muscles after injection cerebrospinal fluid (CSF), which represents an outstanding new property can be useful treatment diseases affecting both muscle.

Язык: Английский

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Chronic Pain in Musculoskeletal Diseases: Do You Know Your Enemy?

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(9), С. 2609 - 2609

Опубликована: Май 6, 2022

Musculoskeletal pain is a condition that characterises several diseases and represents constantly growing issue with enormous socio-economic burdens, highlighting the importance of developing treatment algorithms appropriate to patient’s needs effective management strategies. Indeed, algic must be assessed treated independently underlying pathological process since it has an extremely negative impact on emotional psychic aspects individual, leading isolation depression. A full understanding pathophysiological mechanisms involved in nociceptive stimulation central sensitization important step improving approaches musculoskeletal pain. In this context, bidirectional relationship between immune cells neurons nociception could represent key point these mechanisms. Therefore, we provide updated overview magnitude problem, terms prevalence costs, summarise role most molecular players development maintenance Finally, based mechanisms, propose model, called “musculoskeletal cycle”, which useful tool counteract resignation starting for algorithm patient

Язык: Английский

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Pharmacological Methods of Pain Management: Narrative Review of Medication Used

International Journal of General Medicine, Год журнала: 2023, Номер Volume 16, С. 3247 - 3256

Опубликована: Июль 1, 2023

Background: Pain management is a critical aspect of healthcare, aimed at alleviating discomfort and improving the quality life for individuals experiencing acute or chronic pain. Pharmacological methods constitute primary approach to pain management, including diverse array drugs that work through different mechanisms. Aim: Identifying medications commonly employed in focusing on their mechanism actions, uses, efficacy pharmacological applications. Methods: The methodology involved systematic search scientific literature using various databases, PubMed, Scopus, Google Scholar. Relevant articles published between 2000 2023 were screened inclusion. selected studies encompassed original research, review articles, therapeutic guidelines randomized controlled trials. Results: findings this suggest multimodal combining analgesics can enhance relief while minimizing adverse effects. It emphasizes importance assessing intensity, determining underlying etiology, utilizing evidence-based optimize outcomes. Conclusion: are an essential component strategies achieve optimal article concludes with discussion emerging trends future directions novel drug targets advances delivery systems. Keywords: pain, pharmacology, neuroscience, analgesia, hypersensitivity

Язык: Английский

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Activation of Mast Cells by Neuropeptides: The Role of Pro-Inflammatory and Anti-Inflammatory Cytokines

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4811 - 4811

Опубликована: Март 2, 2023

Mast cells (MCs) are tissue that derived from bone marrow stem contribute to allergic reactions, inflammatory diseases, innate and adaptive immunity, autoimmunity, mental disorders. MCs located near the meninges communicate with microglia through production of mediators such as histamine tryptase, but also secretion IL-1, IL-6 TNF, which can create pathological effects in brain. Preformed chemical inflammation tumor necrosis factor (TNF) rapidly released granules MCs, only immune capable storing cytokine although it be produced later mRNA. The role nervous system diseases has been extensively studied reported scientific literature; is great clinical interest. However, many published articles concern studies on animals (mainly rats or mice) not humans. known interact neuropeptides mediate endothelial cell activation, resulting central (CNS) In brain, neurons causing neuronal excitation release cytokines chemokines. This article explores current understanding MC activation by neuropeptide substance P (SP), corticotropin-releasing hormone (CRH), neurotensin, pro-inflammatory cytokines, suggesting a therapeutic effect anti-inflammatory IL-37 IL-38.

Язык: Английский

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