International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(18), С. 10659 - 10659
Опубликована: Сен. 13, 2022
Endothelial
mechanics
control
vascular
reactivity
and
are
regulated
by
the
mineralocorticoid
receptor
(MR)
its
downstream
target,
epithelial
Na+
channel
(ENaC).
dysfunction
is
a
hallmark
of
chronic
kidney
disease
(CKD),
but
mechanisms
poorly
understood.
We
hypothesized
that
CKD
disrupts
endothelial
in
an
MR/ENaC-dependent
process.Primary
human
cells
were
cultured
with
uremic
serum
derived
from
children
stage
3-5
(predialysis)
or
adult
hemodialysis
(HD)
patients
healthy
controls.
The
height
stiffness
glycocalyx
(eGC)
cortex
monitored
atomic
force
microscopy
(AFM)
using
ultrasensitive
mechanical
nanosensor.In
stage-dependent
manner,
sera
induced
significant
increase
eGC
incremental
reduction
height.
AFM
measurements
significantly
associated
individual
pulse
wave
velocity
concentrations
gut-derived
toxins.
Serum
HD
increased
MR
expression
cortex,
effect
reversed
ENaC
antagonists,
decreased
eNOS
NO
bioavailability,
augmented
monocyte
adhesion.These
data
indicate
progressive
structural
damage
surface
diminishing
function
identify
as
mediator
CKD-induced
dysfunction.
Clinics and Practice,
Год журнала:
2023,
Номер
13(4), С. 881 - 888
Опубликована: Авг. 1, 2023
Chronic
kidney
disease
(CKD)
is
a
global
health
challenge
affecting
nearly
700
million
people
worldwide.
In
the
United
States
alone,
Medicare
costs
for
CKD
management
has
reached
USD
80
billion
per
year.
While
reversing
may
be
possible
in
future,
current
strategies
aim
to
slow
its
progression.
For
most
part,
have
focused
on
employing
Renin
Angiotensin
Aldosterone
(RAS)
inhibitors
and
optimizing
blood
pressure
diabetes
mellitus
control.
Emerging
data
are
showing
that
disruption
of
gut-kidney
axis
significant
impact
delaying
Recent
investigations
documented
promising
results
using
microbiota-based
interventions
better
manage
CKD.
This
review
will
summarize
evidence
explore
future
possibilities
use
probiotics,
prebiotics,
synbiotics,
fecal
microbial
transplant
reduce
Heliyon,
Год журнала:
2024,
Номер
10(15), С. e35032 - e35032
Опубликована: Июль 24, 2024
The
uremic
toxin
indoxyl
sulfate
(IS)
has
been
related
to
the
development
of
various
medical
conditions
notably
chronic
kidney
disease
(CKD).
Hence,
quantification
this
biomarker
in
biological
fluids
may
be
a
diagnostic
tool
evaluate
renal
system
functionality.
Numerous
analytical
methods
including
liquid
chromatography,
gas
spectroscopy,
and
electrochemical
techniques
have
since
used
analyze
IS
different
fluids.
current
review
highlights
relevant
studies
that
assessed
with
special
focus
on
sample
preparation,
which
is
essential
reduce
or
eliminate
effect
endogenous
components
from
matrix
bioanalysis.
Current Opinion in Nephrology & Hypertension,
Год журнала:
2021,
Номер
30(2), С. 231 - 236
Опубликована: Янв. 13, 2021
Purpose
of
review
Cardiovascular
disease
(CVD)
is
a
significant
cause
morbidity
and
mortality
in
children
with
chronic
kidney
(CKD).
The
CVD
CKD
multifactorial
there
are
new
emerging
data
regarding
prevalence
risk
factors
for
this
population.
Recent
findings
A
number
recent
publications
from
longitudinal
cohort
studies
have
greatly
increased
our
knowledge
about
the
including
hypertension,
obesity
dyslipidaemia.
Masked
hypertension
isolated
nocturnal
both
correlate
surrogate
markers
children.
Obesity
adiposity
associated
an
CVD.
Markers
other
than
BMI
such
as
waist
to
height
ratio
fat-free
tissue
fat
better
presence
Dyslipidaemia
extremely
prevalent
paediatric
population,
but
lack
consensus
on
treatment.
More
relationship
between
bone
mineral
continue
emerge
association
hyperparathyroidism
hypertension.
Summary
Children
multiple
potentially
modifiable
Research
focused
outcomes
needed.
Toxins,
Год журнала:
2021,
Номер
13(7), С. 450 - 450
Опубликована: Июнь 29, 2021
Chronic
kidney
disease
(CKD)
is
a
condition
of
widespread
epidemiology
and
serious
consequences
affecting
all
organs
the
organism
associated
with
significant
mortality.
The
knowledge
on
CKD
rapidly
evolving,
especially
concerning
adults.
Recently,
more
data
also
appearing
regarding
in
children.
itch
(CI)
common
symptom
due
to
various
underlying
dermatological
systemic
conditions.
CI
may
appear
association
termed
chronic
disease-associated
(CKD-aI).
CKD-aI
relatively
well-described
literature
adults,
yet
it
affects
Unfortunately,
paediatric
particularly
scarce.
This
narrative
review
aims
describe
aspects
an
emphasis
children,
based
available
this
population
extrapolated
from
Its
pathogenesis
described
details,
focusing
growing
role
uraemic
toxins
(UTs),
as
well
immune
dysfunction,
altered
opioid
transmission,
infectious
agents,
xerosis,
neuropathy
dialysis-associated
aspects.
Moreover,
epidemiological
clinical
are
reviewed
few
whereas
treatment
recommendations
proposed
well,
adults
own
experience
managing
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(18), С. 10659 - 10659
Опубликована: Сен. 13, 2022
Endothelial
mechanics
control
vascular
reactivity
and
are
regulated
by
the
mineralocorticoid
receptor
(MR)
its
downstream
target,
epithelial
Na+
channel
(ENaC).
dysfunction
is
a
hallmark
of
chronic
kidney
disease
(CKD),
but
mechanisms
poorly
understood.
We
hypothesized
that
CKD
disrupts
endothelial
in
an
MR/ENaC-dependent
process.Primary
human
cells
were
cultured
with
uremic
serum
derived
from
children
stage
3-5
(predialysis)
or
adult
hemodialysis
(HD)
patients
healthy
controls.
The
height
stiffness
glycocalyx
(eGC)
cortex
monitored
atomic
force
microscopy
(AFM)
using
ultrasensitive
mechanical
nanosensor.In
stage-dependent
manner,
sera
induced
significant
increase
eGC
incremental
reduction
height.
AFM
measurements
significantly
associated
individual
pulse
wave
velocity
concentrations
gut-derived
toxins.
Serum
HD
increased
MR
expression
cortex,
effect
reversed
ENaC
antagonists,
decreased
eNOS
NO
bioavailability,
augmented
monocyte
adhesion.These
data
indicate
progressive
structural
damage
surface
diminishing
function
identify
as
mediator
CKD-induced
dysfunction.
