Brazilian Journals Editora eBooks, Год журнала: 2023, Номер unknown, С. 268 - 273
Опубликована: Авг. 29, 2023
A construção do conhecimento inicia, a partir da integração de temas e profissões, sobre obras científicas.Neste livro o leitor encontrará um leque propostas educacionais, onde cultura, ensaio pesquisa andam juntas, com intuito único, promoção pensamento crítico reflexivo os assuntos abordados.Este contempla estrutura vinte capítulos,
Journal of the Pediatric Infectious Diseases Society, Год журнала: 2024, Номер 13(7), С. 352 - 362
Опубликована: Май 22, 2024
Abstract Background Risk stratification is a cornerstone of the Pediatric Infectious Diseases Society COVID-19 treatment guidance. This systematic review and meta-analysis aimed to define clinical characteristics comorbidities associated with critical in children adolescents. Methods Two independent reviewers screened literature (Medline EMBASE) for studies published through August 31, 2023, that reported outcome data on patients aged ≤21 years COVID-19. Critical disease was defined as an invasive mechanical ventilation requirement, intensive care unit admission, or death. Random-effects models were used estimate pooled odds ratios (OR) 95% confidence intervals (CI), heterogeneity explored subgroup analyses. Results Among 10,178 articles, 136 met inclusion criteria review. Data from 70 studies, which collectively examined 172,165 adolescents COVID-19, meta-analysis. In previously healthy children, absolute risk 4% (95% CI, 1%–10%). Compared no comorbidities, OR 3.95 2.78–5.63) presence one comorbidity 9.51 5.62–16.06) ≥2 comorbidities. Key factors included cardiovascular neurological disorders, chronic pulmonary conditions (excluding asthma), diabetes, obesity, immunocompromise, all statistically significant ORs > 2.00. Conclusions While without underlying health relatively low, more markedly increased risk. These findings support importance tailoring pediatric management.
Язык: Английский
Процитировано
9
Clinical and Experimental Pediatrics, Год журнала: 2023, Номер 66(10), С. 424 - 431
Опубликована: Июль 2, 2023
Coronavirus disease 2019 (COVID-19) has spread considerably across the globe, affecting numerous children and adolescents besides adults. Despite its relatively lower incidence rates in than adults, some infected exhibit a severe postinflammatory response known as multisystem inflammatory syndrome children, followed by acute kidney injury, common complication. Meanwhile, few reports have been available regarding complications such idiopathic nephrotic other glomerulopathies associated with COVID-19 infection vaccination adolescents. However, morbidity mortality of these are not exceptionally high; more importantly, causality yet to be clearly established. Finally, vaccine hesitancy age groups should addressed, considering strong evidence safety efficacy.
Язык: Английский
Процитировано
5
Pediatric Nephrology, Год журнала: 2023, Номер 38(11), С. 3681 - 3692
Опубликована: Май 16, 2023
The aetiology of idiopathic nephrotic syndrome (INS) remains partially unknown. Viral infections have been associated with INS onset. Since we observed fewer first onset cases during the Covid-19 pandemic, hypothesised that lower incidence was result lockdown measures. Therefore, aim this study to evaluate childhood before and COVID-19 pandemic in two independent European cohorts.Children new Netherlands (2018-2021) Paris area were included. We estimated incidences using census data for each region. Incidences compared proportion Z-tests.A total 128 324 reported area, respectively, corresponding an annual 1.21 2.58 per 100,000 children/year. Boys young children (< 7 years) more frequently affected. Incidence did not differ. When schools closed, both regions: 0.53 vs. 1.31 (p = 0.017) 0.94 2.63 0.049) area. During peaks hospital admissions Covid-19, no or area.Incidence different, but when closed lockdown, significantly lower. Interestingly, other respiratory viral also reduced as air pollution. Together, these results argue a link between and/or environmental factors. A higher resolution version Graphical abstract is available Supplementary information.
Язык: Английский
Процитировано
4
BMC Pediatrics, Год журнала: 2023, Номер 23(1)
Опубликована: Сен. 28, 2023
As the coronavirus disease-2019 (COVID-19) pandemic continues, driven by Omicron variant, infection rates in children have recently rapidly surged compared with previous years. We aimed to investigate presentation of kidney involvement after variant severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection.We retrospectively reviewed medical records pediatric patients who presented disease a temporal relationship COVID-19 between January and August 2022 single tertiary center Korea.Fifteen infection, median age 10.6 (6.8-18.3) None exhibited symptoms apart from cough sore throat. The time renal symptom onset was 3 (0-49) days. Among 10 underlying disease, six had previously been diagnosed nephrotic (NS) that relapsed two immunoglobulin A nephropathy (IgAN) experienced transient gross hematuria (GHU) or without injury (AKI), transplantation AKI. Of five one patient NS, other four GHU proteinuria (PU), whom eventually Henoch Shönlein Purpura nephritis (HSPN), rhabdomyolysis. seven NS (1 new-onset, 6 relapsed) uneventful remission corticosteroid therapy. Apart new-onset HSPN, PU resolved spontaneously all affected patients, AKI also supportive care.Kidney subsequent various, but mostly mild manifestations children.
Язык: Английский
Процитировано
3
Brazilian Journals Editora eBooks, Год журнала: 2023, Номер unknown, С. 167 - 184
Опубликована: Авг. 29, 2023
A construção do conhecimento inicia, a partir da integração de temas e profissões, sobre obras científicas.Neste livro o leitor encontrará um leque propostas educacionais, onde cultura, ensaio pesquisa andam juntas, com intuito único, promoção pensamento crítico reflexivo os assuntos abordados.Este contempla estrutura vinte capítulos,
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Янв. 18, 2024
Abstract Background Risk stratification is a cornerstone of the Pediatric Infectious Diseases Society COVID-19 treatment guidance. This systematic review and meta-analysis aimed to define clinical characteristics comorbidities associated with critical in children adolescents. Methods Two independent reviewers screened literature (Medline EMBASE) for studies published through August 2023 that reported outcome data on patients aged ≤ 21 years COVID-19. Critical disease was defined as an invasive mechanical ventilation requirement, intensive care unit admission, or death. Random effects models were used estimate pooled odds ratios (OR) 95% confidence intervals (CI), heterogeneity explored subgroup analyses. Results Among 10,178 articles, 136 met inclusion criteria review. Data from 70 studies, which collectively examined 172,165 adolescents COVID-19, meta-analysis. In previously healthy children, absolute risk 4% (95% CI, 1%–10%). Compared no comorbidities, OR 3.95 2.78–5.63) presence one comorbidity 9.51 5.62–16.06) ≥ 2 comorbidities. Key factors included cardiovascular neurological disorders, chronic pulmonary conditions (excluding asthma), diabetes, obesity, immunocompromise, all statistically significant ORs >2.00. Conclusions While without underlying health relatively low, more markedly increased risk. These findings support importance tailoring pediatric management. Summary integrated (172,165 patients) identified diabetes; obesity; immunocompromise; cardiovascular, neurological, predictors severe The multiple increases outcomes.
Язык: Английский
Процитировано
0
Research Square (Research Square), Год журнала: 2023, Номер unknown
Опубликована: Май 16, 2023
Abstract Background As the COVID-19 pandemic persists with Omicron variants, infection rates in children have rapidly increased compared to previous years. We aimed investigate presentation of kidney involvement after variant infection. Methods retrospectively reviewed medical records pediatric patients who presented between January and August 2022 a temporal relationship from Korean single tertiary center. Results Fifteen infection, median age 10.6 (6.8–18.3) Aside fever, cough, sore throat, diarrhea, none had severe respiratory symptoms. The time renal symptom onset was 3 (0–49) days. Among 10 underlying disease, 6 previously been diagnosed nephrotic syndrome (NS) that relapsed 2 immunoglobulin A nephropathy (IgAN) showed transient gross hematuria (GHU) or without acute injury (AKI), transplantation AKI. Of 5 one patient NS, other 4 GHU proteinuria (PU), whom eventually Henoch-Shönlein purpura nephritis (HSPN). Seven NS (1 new-onset, relapsed) uneventful remission corticosteroids. Other than new-onset HSPN, PU resolved spontaneously, AKI also supportive care. Conclusions Kidney can occur various, but mostly non-fatal manifestations
Язык: Английский
Процитировано
0
Brazilian Journals Editora eBooks, Год журнала: 2023, Номер unknown, С. 274 - 283
Опубликована: Авг. 29, 2023
A construção do conhecimento inicia, a partir da integração de temas e profissões, sobre obras científicas.Neste livro o leitor encontrará um leque propostas educacionais, onde cultura, ensaio pesquisa andam juntas, com intuito único, promoção pensamento crítico reflexivo os assuntos abordados.Este contempla estrutura vinte capítulos,
Процитировано
0
Brazilian Journals Editora eBooks, Год журнала: 2023, Номер unknown, С. 86 - 99
Опубликована: Авг. 29, 2023
A construção do conhecimento inicia, a partir da integração de temas e profissões, sobre obras científicas.Neste livro o leitor encontrará um leque propostas educacionais, onde cultura, ensaio pesquisa andam juntas, com intuito único, promoção pensamento crítico reflexivo os assuntos abordados.Este contempla estrutura vinte capítulos,
Процитировано
0
Brazilian Journals Editora eBooks, Год журнала: 2023, Номер unknown, С. 33 - 42
Опубликована: Авг. 29, 2023
A construção do conhecimento inicia, a partir da integração de temas e profissões, sobre obras científicas.Neste livro o leitor encontrará um leque propostas educacionais, onde cultura, ensaio pesquisa andam juntas, com intuito único, promoção pensamento crítico reflexivo os assuntos abordados.Este contempla estrutura vinte capítulos,
Процитировано
0