Climate change and heat stress resilient outdoor workers: findings from systematic literature review

BMC Public Health, Год журнала: 2024, Номер 24(1)

Опубликована: Июнь 26, 2024

Abstract Purpose Global warming has led to an increase in the number and intensity of extreme heat events, posing a significant threat health safety workers, especially those working outdoors, as they often have limited access cooling strategies. The present systematic literature review (a) summarizes current knowledge on impacts climate change outdoor (b) provides historical background this issue, (c) explores factors that reduce thermal stress resilience, (d) discusses mitigation strategies, (e) overview existing policy legal frameworks occupational exposure among workers. Materials methods In review, we searched scientific databases including Scopus ( N = 855), Web Science 828), PubMed 202). Additionally, identified relevant studies heat-stress control measures through Google Scholar 116) using specific search terms. total, monitored 2001 articles pertaining worker populations (men 2921; women 627) various conditions across 14 countries. After full-text assessment, 55 were selected for inclusion, finally, 29 eligible papers included data extraction. Results Failure implement effective strategies workers will result decreased resilience stress. findings underscore lack awareness regarding certain adaptation interventions aimed at preventing enhancing impact prevalence tropical subtropical environments. However, attractive alternative solutions from aspects economic ecological sustainability overall assessment can be referred acclimatization, shading, optimized clothing properties planned breaks. Conclusion integration into programs enhance Conducting cost-benefit evaluations is crucial professionals policymakers low- middle-income respect, complementary targeting hydration, work-rest regimes, ventilated garments, self-pacing, mechanization adopted protect Risk management adaptive measures, risk awareness, practical interventions, training programs, protective policies should implemented hot-dry hot-humid climates boost tolerance

Язык: Английский

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Adaptation of the Spalax galili transcriptome to hypoxia may underlie the complex phenotype featuring longevity and cancer resistance

npj Aging, Год журнала: 2025, Номер 11(1)

Опубликована: Март 6, 2025

In the subterranean rodent (Nanno)spalax galili, evolutionary adaptation to hypoxia is correlated with longevity and tumor resistance. Adapted gene-regulatory networks of Spalax might pinpoint strategies maintain health in humans. Comparing liver, kidney spleen transcriptome data from rat at normoxia, we identified differentially expressed gene pathways common multiple organs both species. Body-wide interspecies differences affected processes like cell death, antioxidant defense, DNA repair, energy metabolism, immune response angiogenesis, which may play a crucial role Spalax's environmental hypoxia. all organs, transcription genes for genome stability maintenance repair was elevated versus rat, accompanied by lower expression aerobic metabolism proinflammatory genes. These transcriptomic changes account extraordinary lifespan its cancer The present candidates further investigating molecular basis underlying complex phenotype.

Язык: Английский

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Climate change and chronic kidney disease (CKD) among outdoor workers: a systematic review

International Journal of Biometeorology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 5, 2025

Язык: Английский

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Early Pulmonary Fibrosis-like Changes in the Setting of Heat Exposure: DNA Damage and Cell Senescence

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2992 - 2992

Опубликована: Март 5, 2024

It is well known that extreme heat events happen frequently due to climate change. However, studies examining the direct health impacts of increased temperature and waves are lacking. Previous reports revealed heatstroke induced acute lung injury pulmonary dysfunction. This study aimed investigate whether exposure fibrosis explore underlying mechanisms. Male C57BL/6 mice were exposed an ambient 39.5 ± 0.5 °C until their core reached maximum or exhaustion state. Lung was observed in lungs heat-exposed mice, with extensive collagen deposition elevated expression molecules, including transforming growth factor-β1 (TGF-β1) Fibronectin (Fn1) (p < 0.05). Moreover, epithelial–mesenchymal transition (EMT) occurred response exposure, evidenced by E-cadherin, epithelial marker, which downregulated, whereas markers EMT, such as connective tissue factor (CTGF) zinc finger transcriptional repressor protein Slug, upregulated tissues Subsequently, cell senescence examination levels both senescence-associated β-galactosidase (SA-β-gal) staining cycle kinase inhibitor p21 significantly Mechanistically, cGAS–STING signaling pathway evoked DNA damage activated In summary, we reported a new finding contributed development early fibrosis-like changes through damage-activated followed cellular senescence.

Язык: Английский

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Fisetin Protects C2C12 Mouse Myoblasts from Oxidative Stress-Induced Cytotoxicity through Regulation of the Nrf2/HO-1 Signaling

Journal of Microbiology and Biotechnology, Год журнала: 2023, Номер 33(5), С. 591 - 599

Опубликована: Янв. 20, 2023

Язык: Английский

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Vitamin C Alleviates the Negative Effects of Heat Stress on Reproductive Processes by Regulating Amino Acid Metabolism in Granulosa Cells

Antioxidants, Год журнала: 2024, Номер 13(6), С. 653 - 653

Опубликована: Май 27, 2024

Heat stress-induced biochemical alterations in ovarian follicles compromise the function of granulosa cells (GCs) and developmental competence oocytes. Summer heat stress can have a far-reaching negative impact on overall fertility reproductive success. Together with stress, rise assisted technologies (ART), potential confounding hazards vitro handling absence systemic body support ART makes it imperative to study ameliorative effects vitamin C under conditions. Using treatment 43 °C for two hours bovine GCs, we studied cell growth, oxidative apoptosis cycle progression together comprehensive metabolomics profiling. This investigates molecular milieu underlying (VC)-led alleviation heat-related disruptions metabolic processes GCs. The supplementation VC ameliorated detrimental by reducing while restoring proliferation. Normal restoration treated GCs was demonstrated through finding significantly high levels progesterone. We observed shift metabolome from biosynthesis catabolism, mostly dominated metabolism amino acids (decreased tryptophan, methionine tyrosine) active TCA increased Succinic acid. Glutathione tryptophan were important ameliorating inflammation nexus stress. Two significant enzymes identified, namely 2,3-dioxygenase (TDO2) mitochondrial phenylalanyl-tRNA synthetase (FARS2). Furthermore, our findings provide insight into significance B-complex vitamins context during supplementation. underscores importance designates multiple intervention faucets enhancing efficiency.

Язык: Английский

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Ultrarare Variants in DNA Damage Repair Genes in Pediatric Acute-Onset Neuropsychiatric Syndrome or Acute Behavioral Regression in Neurodevelopmental Disorders

Developmental Neuroscience, Год журнала: 2024, Номер unknown, С. 1 - 20

Опубликована: Окт. 11, 2024

Introduction: Acute onset of severe psychiatric symptoms or regression may occur in children with premorbid neurodevelopmental disorders, although typically developing can also be affected. Infections other stressors are likely triggers. The underlying causes unclear, but a current hypothesis suggests the convergence genes that influence neuronal and immunological function. We previously identified 11 pediatric acute-onset neuropsychiatric syndrome (PANS), which two classes related to either synaptic function immune system were found. Among latter, three affect DNA damage response (DDR): PPM1D, CHK2, RAG1. now report an additional 17 cases mutations PPM1D DDR patients acute and/or their clinicians classified as PANS another inflammatory brain condition. Methods: analyzed genetic findings obtained from parents carried out whole-exome sequencing on total cases, included 3 sibling pairs family 4 affected children. Results: include clusters affecting p53 repair (PPM1D, ATM, ATR, 53BP1, RMRP), Fanconi Anemia Complex (FANCE, SLX4/FANCP, FANCA, FANCI, FANCC). hypothesize defects genes, context infection stressors, could contribute decompensated states through increase genomic instability concomitant accumulation cytosolic cells triggering sensors, such cGAS-STING AIM2 inflammasomes, well central deficits neuroplasticity. In addition, increased senescence defective apoptosis responses playing role. Conclusion: These compelling preliminary motivate further functional characterization downstream impact point novel treatment strategies.

Язык: Английский

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Ultrarare Variants in DNA Damage Repair Genes in Pediatric Acute-Onset Neuropsychiatric Syndrome or Acute Behavioral Regression in Neurodevelopmental Disorders

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 23, 2024

Abstract Acute onset of severe psychiatric symptoms or regression may occur in children with premorbid neurodevelopmental disorders, although typically developing can also be affected. Infections other stressors are likely triggers. The underlying causes unclear, but a current hypothesis suggests the convergence genes that influence neuronal and immunological function. We previously identified 11 Pediatric Acute-Onset Neuropsychiatry Syndrome (PANS), which two classes related to either synaptic function immune system were found. Among latter, three affect DNA damage response (DDR): PPM1D, CHK2, RAG1 . now report an additional 17 cases mutations PPM1D DDR patients acute and/or classified by their clinicians as PANS another inflammatory brain condition. include clusters affecting p53 repair ( , ATM, ATR 53BP1, RMRP ), Fanconi Anemia Complex FANCE, SLX4/FANCP, FANCA, FANCI, FANCC ). hypothesize defects genes, context infection stressors, could lead increase cytosolic cells triggering sensors, such cGAS-STING AIM2 inflammasomes. These findings new treatment strategies.

Язык: Английский

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Lessons from evolution by natural selection: An unprecedented opportunity to use biomimetics to improve planetary health

Journal of Environmental Management, Год журнала: 2022, Номер 328, С. 116981 - 116981

Опубликована: Дек. 9, 2022

Planetary health embraces the concept that long-term human welfare depends on well-being of its ecological systems. Current practices, however, have often ignored this and led to an anthropocentric world, with consequence increased greenhouse gas emissions, heat stress, lack clean water pollution, are threatening environment as well life Homo sapiens many other species. One environmental stressors has been stimulation inflammatory oxidative stress may not only promote common lifestyle diseases, but ageing process. Despite harshness current reality, treatment opportunities exist 'in our backyard'. Biomimicry is emerging field research explores how nature structured aims mimic ingenious solutions evolved in for different applications benefit life. As always counteracts excesses from within, biodiversity could be a source through natural selection animal species survived polluted, warm, arid environments - i.e. same presumptive changes now threaten health. example science suggests animals use cytoprotective Nrf2 antioxidant pathway combat case we can apply better Learning provide management most challenging issue face future planet.

Язык: Английский

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Differential environmental-induced heat stresses cause the structural and molecular changes in the spleen of Japanese flounder (Paralichthys olivaceus)

Aquaculture, Год журнала: 2023, Номер 581, С. 740490 - 740490

Опубликована: Дек. 16, 2023

Язык: Английский

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