Protective Effect of Citicoline on Sodium Arsenite-Induced Nephrotoxicity in Mice DOI Open Access
Mohammad Javad Khodayar, Maryam Shirani, Mehrad Nikravesh

и другие.

Jundishapur Journal of Natural Pharmaceutical Products, Год журнала: 2024, Номер 19(2)

Опубликована: Фев. 28, 2024

Background: Sodium arsenite (NaAsO2) is a common mineral contaminant in drinking water numerous parts of the world. It has been shown to have cardiovascular, metabolic, neuroendocrine, and urinary effects on body. There abundant scientific evidence that establishes strong correlation between arsenic exposure kidney-related disorders. Objectives: The present study aimed investigate potential protective effect citicoline against NaAsO2-induced nephrotoxicity. Methods: groups included control group, group treated with NaAsO2 at concentration 50 ppm, Cit dosage 1000 mg/kg, three (50 ppm) co-treated doses 250, 500, respectively. Results: Citicoline decreased level blood urea nitrogen (P < 0.001), creatinine levels thiobarbituric acid reactive substances nitric oxide inflammatory factors tumor necrosis factor-α 0.001) interleukin-6 0.001 P 0.001). Furthermore, increased total thiol activity catalase 0.05 superoxide dismutase 0.01 glutathione peroxidase Therefore, reduced harmful caused by imbalance oxidative antioxidant systems histopathological damage NaAsO2-intoxicated mice, improving stress inflammation. Conclusions: Our research shows can protect kidneys damaging using its anti-inflammatory properties.

Язык: Английский

Betaine and the probiotic, Lactobacillus rhamnosus in the diet of the Common carp, Cyprinus carpio: Effects on growth, digestive enzyme activities, antioxidant system, humoral and mucosal immunity and resistance to Streptococcus iniae DOI Creative Commons
Saeed Hajirezaee,

Sudabe Ramezani,

Sara Ahani

и другие.

Aquaculture Reports, Год журнала: 2024, Номер 38, С. 102282 - 102282

Опубликована: Авг. 3, 2024

Язык: Английский

Процитировано

4
Protective Effect of Citicoline on Sodium Arsenite-Induced Nephrotoxicity in Mice DOI Open Access
Mohammad Javad Khodayar, Maryam Shirani, Mehrad Nikravesh

и другие.

Jundishapur Journal of Natural Pharmaceutical Products, Год журнала: 2024, Номер 19(2)

Опубликована: Фев. 28, 2024

Background: Sodium arsenite (NaAsO2) is a common mineral contaminant in drinking water numerous parts of the world. It has been shown to have cardiovascular, metabolic, neuroendocrine, and urinary effects on body. There abundant scientific evidence that establishes strong correlation between arsenic exposure kidney-related disorders. Objectives: The present study aimed investigate potential protective effect citicoline against NaAsO2-induced nephrotoxicity. Methods: groups included control group, group treated with NaAsO2 at concentration 50 ppm, Cit dosage 1000 mg/kg, three (50 ppm) co-treated doses 250, 500, respectively. Results: Citicoline decreased level blood urea nitrogen (P < 0.001), creatinine levels thiobarbituric acid reactive substances nitric oxide inflammatory factors tumor necrosis factor-α 0.001) interleukin-6 0.001 P 0.001). Furthermore, increased total thiol activity catalase 0.05 superoxide dismutase 0.01 glutathione peroxidase Therefore, reduced harmful caused by imbalance oxidative antioxidant systems histopathological damage NaAsO2-intoxicated mice, improving stress inflammation. Conclusions: Our research shows can protect kidneys damaging using its anti-inflammatory properties.

Язык: Английский

Процитировано

0