DNP – Die Neurologie & Psychiatrie, Год журнала: 2023, Номер 24(6), С. 62 - 69
Опубликована: Дек. 1, 2023
Frontiers in Neurology, Год журнала: 2024, Номер 15
Опубликована: Апрель 5, 2024
Introduction Apomorphine, a potent dopamine agonist, is therapeutic option for patients with Parkinson’s disease and motor fluctuations. However, the adoption of adherence to this therapy have been limited by need complex delivery devices specialized care as well resource consumption, posing challenges new physicians. Thailand unique example developing nation that has successfully implemented continued use employing cooperative technology dramatically enhanced apomorphine services. Methods Establishing services requires significant resources step-by-step solutions. We began our implementing various strategies in three chronological stages: initial stage (2013–2015), intermediate (2016–2019), current (2020–present), each presenting challenges. Together, we also proposed set five mottos strengthen service. Using additive technology, developed patient registry platform combined electronic data acquisition, video remote monitoring using wearable sensors, in-house mobile applications support Results At stage, assembled team enhance efficacy confirm safety treatment hospital. expanded beyond just at supported other hospitals setting up their own educating both physicians nurses regarding therapy. With educational undertaking, increased apomorphine-related knowledge among medical professionals, greater number providing services, an increasing were administered subsequent years. Currently, are effective improve outcomes seamlessly integrating into clinical practice. Incorporating integrative technologies program yielded positive results collection throughout care, tracking patients’ statuses, long-term treatment, medication rates. Conclusion This perspective paper describes how can help provide supportive healthcare resource-constrained environments, such Thailand, offering approach overcoming several limitations. The valuable insights from 10-year journey benefit seeking replicate success.
Язык: Английский
Процитировано
1
STUDIES IN HEALTH SCIENCES, Год журнала: 2024, Номер 5(1), С. 109 - 120
Опубликована: Янв. 26, 2024
A Doença de Parkinson (DP) é uma doença neurológica que afeta os movimentos, causando tremores, lentidão, rigidez muscular, desequilíbrio, além alterações na fala e escrita. Essa ocorre por degeneração das células situadas numa região do cérebro chamada substância nigra. Inicialmente, deve-se começar com o tratamento medicamentoso, quais são pautados concentração presente dopamina Todavia, tratamentos cirúrgicos transformaram manejo da Parkinson. As opções terapêuticas disponíveis para complicações motoras DP incluem estimulação cerebral profunda (ECP), procedimentos ablativos ou lesionais dispositivos infusão medicamentos dopaminérgicos. Dessa forma, crescente corpo literatura sobre indicações cirurgia DP, foi possível a realização revisão integrativa meio plataforma pubmed, seleção análise criteriosa dos artigos, fim revisar analisar as evidências atuais pacientes Nesta identificado orais, dopaminérgicas não dopaminérgicas, base desta doença, sendo eficaz no início tratamento. No entanto, progressão uso crônico terapias podem desenvolver flutuações discinesia. Portanto, cirúrgicas outras avançado devem ser consideradas cujos sintomas adequadamente controlados apenas orais. Os avançados considerados quando incômodas se tornam refratárias mudanças nos DRT padrão leva incômodos, exemplo, discinesia, mas também distúrbios controle impulsos.
Процитировано
0
Journal of Neural Transmission, Год журнала: 2024, Номер 131(11), С. 1295 - 1305
Опубликована: Июль 15, 2024
Several screening tools are available to assist general neurologists in the timely identification of patients with advanced Parkinson's disease (PD) who may be eligible for referral a device-aided therapy (DAT). However, it should noted that not all these clinical decision rules have been developed and validated thorough consistent manner. Furthermore, only limited number head-to-head comparisons performed. Available studies suggest D-DATS has higher positive predictive value specificity than 5-2-1 criteria, while sensitivity both is similar. unanswered questions remain regarding validity rules, such as whether diagnostic performance measures from validation generalizable other populations. Ultimately, question tool will effectively efficiently improve quality life PD. To address this key question, an impact analysis The authors intend set up multinational cluster randomised controlled trial compare criteria on downstream consequences implementing tools, particular focus disability life.
Язык: Английский
Процитировано
0
Brain Sciences, Год журнала: 2024, Номер 14(12), С. 1244 - 1244
Опубликована: Дек. 12, 2024
Background and objective: Staging Parkinson’s disease (PD) with a novel simple classification called MNCD, based on four axes (Motor; Non-motor; Cognition; Dependency) five stages, correlated severity, patients’ quality of life caregivers’ strain burden. Our aim was to apply the MNCD in advanced PD patients treated device-aided therapy (DAT). Patients Methods: A multicenter observational retrospective study first start levodopa-entacapone-carbidopa intestinal gel (LECIG) Spain performed (LECIPARK study). The total score (from 0 12) stages 1 5) were collected by neurologist at V0 (before starting LECIG) V2 (follow-up visit). Wilcoxon’s signed rank Marginal Homogeneity tests applied compare changes from V2. Results: Sixty-seven (58.2% males; 69.9 ± 9.3 years old) mean duration 14.4 6.5 included. treatment (V2) 172.9 105.2 days. At V0, classified as stage 2 (35.8%), 3 (46.3%) or 4 (17.9%). frequency decreased 9% (p = 0.001). 6.27 1.94 5.21 2.23 < 0.0001). From V2, motor (M; p 0.0001) non-motor symptom (N; burden decreased, autonomy for activities daily living (D; 0.005) improved. Conclusions: could be useful classify monitor response DAT.
Язык: Английский
Процитировано
0
EMC - Neurologie, Год журнала: 2024, Номер 47(4), С. 1 - 11
Опубликована: Окт. 1, 2024
Процитировано
0
Parkinsonism & Related Disorders, Год журнала: 2023, Номер 116, С. 105862 - 105862
Опубликована: Сен. 19, 2023
Язык: Английский
Процитировано
0
DNP – Die Neurologie & Psychiatrie, Год журнала: 2023, Номер 24(6), С. 62 - 69
Опубликована: Дек. 1, 2023
Процитировано
0