Recent Advances in the Application of 2‐Aminobenzothiazole to the Multicomponent Synthesis of Heterocycles
ChemistryOpen,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 9, 2024
Abstract
Heterocycles
are
a
vital
class
of
compounds
in
numerous
fields,
including
drug
discovery,
agriculture,
and
materials
science.
Efficient
methods
for
the
synthesis
heterocycles
remain
critical
meeting
demands
these
industries.
Recent
advances
multicomponent
reactions
(MCRs)
utilizing
2‐aminobenzothiazole
(ABT)
have
shown
promising
results
formation
heterocycles.
The
versatility
this
context
has
enabled
rapid
efficient
construction
diverse
heterocyclic
structures.
Various
synthetic
methodologies
involving
discussed,
highlighting
its
importance
as
valuable
building
block
complex
potential
applications
discovery
material
science
also
explored.
Overall,
review
provides
comprehensive
overview
current
state
research
field
offers
insights
into
future
directions
area
study.
We
highlight
ABT
versatile
sustainable
starting
via
MCRs,
with
significant
implications
chemical
industry.
Язык: Английский
α-Aminoazoles/azines: key reaction partners for multicomponent reactions
RSC Advances,
Год журнала:
2021,
Номер
11(19), С. 11083 - 11165
Опубликована: Янв. 1, 2021
Aromatic
α-aminoazaheterocycles
are
the
focus
of
significant
investigations
and
exploration
by
researchers
owing
to
their
key
role
in
diverse
biological
physiological
processes.
Язык: Английский
Arylglyoxal-based multicomponent synthesis of C-3 functionalized imidazoheterocycles
Chemical Papers,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Язык: Английский
Synthesis of 4‐Hydroxy‐3‐(2‐arylimidazo[1,2‐a]pyridin‐3‐yl)quinolin‐2(1H)‐ones in the Presence of DABCO as an Efficient Organocatalyst
Journal of Heterocyclic Chemistry,
Год журнала:
2019,
Номер
56(6), С. 1857 - 1865
Опубликована: Май 10, 2019
The
one‐pot,
three‐component,
synthesis
of
a
new
series
4‐hydroxy‐3‐(2‐arylimidazo[1,2‐
]pyridin‐3‐yl)quinolin‐2(1
H
)‐ones
in
the
presence
DABCO
as
catalyst
has
been
achieved
using
aryl
glyoxal
monohydrates,
quinoline‐2,4(1
,3
)‐dione,
and
2‐aminopyridine
2
O/EtOH
under
reflux
conditions.
cheapness
organocatalyst,
simple
workup,
operational
simplicity,
regioselectivity,
high
yields
are
some
advantages
this
protocol.
Язык: Английский
Arylglyoxals as Versatile Synthons for Heterocycles Through Multi-Component Reactions
Current Organic Chemistry,
Год журнала:
2019,
Номер
23(18), С. 1945 - 1983
Опубликована: Окт. 24, 2019
Arylglyoxals
are
important
synthons
that
have
been
used
in
the
construction
of
a
diverse
spectrum
compounds.
The
use
multicomponent
approaches
organic
synthesis
due
to
its
environmentally
friendly
nature
is
step
forward
towards
sustainability.
This
review
will
offer
reader
insightful
perspectives
on
arylglyoxals
for
various
heterocyclic
compounds
like
pyrroles,
pyrazoles,
furans,
imidazoles,
indoles,
oxazoles,
pyridines,
quinazolines,
pyrans,
etc
using
approach.
Язык: Английский
Biological Applications of Imidazothiazole Scaffolds: A Current Review
Journal of Advanced Chemical Sciences,
Год журнала:
2022,
Номер
8(1), С. 756 - 769
Опубликована: Март 31, 2022
Due
to
the
broad-spectrum
biological
activities,
fused
heterocyclic
compounds
are
one
of
most
important
systems
in
medicinal
chemistry.
Among
them,
imidazothiazole
which
contains
a
bridgehead
nitrogen
atom
has
vital
role
because
various
applications
such
as
anticancer,
antimalarial,
antiviral,
etc.
Designing
scaffolds
become
more
their
several
applications.
The
present
review
paper
discusses
numerous
field
medicine.
would
be
useful
future
drug
design
for
development
promising
drug-like
scaffolds.
Язык: Английский
Fe3O4@SiO2 nanoparticle-immobilized Cu(II)-benzoylthiourea complex as a magnetically reusable catalyst for the synthesis of benzo[d]imidazo[2,1-b]thiazole-1-ium hydroxide derivatives in water
Journal of the Iranian Chemical Society,
Год журнала:
2020,
Номер
17(8), С. 2105 - 2117
Опубликована: Апрель 10, 2020
Язык: Английский
Imidazothiazole
Advances in bioinformatics and biomedical engineering book series,
Год журнала:
2024,
Номер
unknown, С. 71 - 110
Опубликована: Ноя. 27, 2024
Recent
research
on
cancer
therapy
has
revealed
that
the
emergence
of
malignant
cells
is
caused
by
several
enzyme
alterations.
such
include
kinase
inhibitors
ErB4
(HER4),
B-Raf
kinase,
and
indoleamine
2,3-dioxygenase
1
(IDO1).
Researchers
discovered
drugs
based
imidazothiazoles,
their
analogues
exhibit
more
robust
anticancer
action
inhibiting
these
enzymatic
receptors.
In
recent
times,
imidazothiazole
scaffold
broadly
explored
for
its
activity,
which
acts
through
various
mechanisms
as
EGFR,
B-RAF,
DHFR
inhibition
tubulin
polymerization
other
molecular
action.
Due
to
feasible
synthetic
accessibility
promising
pharmacological
profile,
it
attracted
medicinal
chemists
explore
develop
derivatives
potent
safe
agents.
present
book
chapter,
we
have
reviewed
scaffold-based
reported
agents,
strategies,
with
future
perspective.
Язык: Английский
Evaluation of 1,3-Thiazole Derivatives with Pharmaceutical and Chemical Activity: a Review
Jyothi Damodara,
Sheetal Tresa Fernandes,
Smitha Maria DSouza
и другие.
Heterocycles,
Год журнала:
2023,
Номер
106(5), С. 819 - 819
Опубликована: Янв. 1, 2023
Язык: Английский
NEW METHODOLOGY TO SYNTHESIS 3- SECONDARY AMINES OF IMIDAZOBENZOTHIAZOLE DERIVATIVES WITH STUDY THEIR BIOLOGICAL ACTIVITIES
Iraqi Journal of Market Research and Consumer Protection,
Год журнала:
2023,
Номер
15(1), С. 193 - 200
Опубликована: Июнь 30, 2023
In
this
research,
new
derivatives
of
bicyclic
fused
rings
containing
bridgehead
nitrogen
atom
imidazo/benzothiazole
were
prepared
from
2-aminobenzothiazole
with
2-bromo-1-(4-bromophenyl)ethan-1-one
to
form
compound
A1.
Then,
through
the
Mannich
reaction,
A2
was
A1
formaldehyde
and
4-aminoacetophenone.
Schiff
bases
A3-A6
condensation
reaction
between
different
amines.
Finally,
reduction
accomplished
by
using
NaBH4
reduce
imine
group
forming
compounds
A7-A10.
These
characterized
FTIR,
1HNMR,
13CNMR.
The
showed
biological
activity
against
some
microorganisms.
Язык: Английский