Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 18, 2023
Abstract
Background
Postpartum
depression
(PPD),
a
prevalent
social
mental
condition,
impacts
not
only
the
mother
and
newborn
but
also
several
facets
of
their
lives.
It
has
been
suggested
that
insomnia
is
related
to
both
occurrence
progression
PPD.
However,
because
lingering
confounding
bias,
it
impossible
determine
cause
this
connection
using
observational
analysis.
In
study,
we
evaluate
causal
importance
on
postpartum
Mendelian
randomization
(MR).
Methods
Utilizing
summary
data
from
genome-wide
association
studies
(GWAS),
two-sample
MR
study
was
conducted.
A
GWAS
dataset
IEU
United
Kingdom
Biobank
phenotypes
comprising
462,341
people
European
heritage
yielded
38
single-nucleotide
polymorphisms
(SNPs)
for
insomnia.
The
PPD
were
provided
by
FinnGen
project
comprised
7604
cases
59601
controls.
Inverse
variance
weighting
(IVW)
utilized
primary
analysis,
with
weighted
median
MR-Egger
serving
as
sensitivity
analyses.
Results
As
result,
found
genetically
predicted
positively
associated
depression.
odds
ratios
(OR)
1.849
(95%
(confidence
interval)
CI:
1.011–3.381;
p
=
0.046).
Conclusion
For
first
time,
causative
role
sleeplessness
extensively
evaluated
in
current
investigation.
Our
findings
show
are
way.
Neurology International,
Год журнала:
2024,
Номер
16(3), С. 522 - 532
Опубликована: Май 7, 2024
Obstructive
sleep
apnea
(OSA)
is
a
prevalent
yet
underdiagnosed
condition
in
pregnancy,
associated
with
various
maternal
and
fetal
complications.
This
review
synthesizes
the
current
evidence
on
epidemiology,
pathophysiology,
neurological
consequences
of
OSA
along
potential
management
strategies.
Articles
were
sourced
from
PubMed,
EMBASE,
Cochrane
databases
until
2023.
Our
comprehensive
highlights
that
incidence
increases
during
pregnancy
due
to
physiological
changes
such
as
weight
gain
hormonal
fluctuations.
linked
gestational
hypertension,
pre-eclampsia,
diabetes,
adverse
outcomes
intrauterine
growth
restriction
preterm
birth.
Continuous
positive
airway
pressure
(CPAP)
therapy
remains
most
effective
strategy
for
pregnant
women
OSA.
However,
adherence
CPAP
often
suboptimal.
underscores
importance
early
recognition,
timely
diagnosis,
improve
both
outcomes.
Future
research
should
focus
enhancing
screening
strategies
improving
this
population.
Frontiers in Psychiatry,
Год журнала:
2023,
Номер
14
Опубликована: Дек. 5, 2023
With
each
passing
year,
the
number
of
people
suffering
from
mental
disorders
grows
at
a
disturbing
speed.
Neuroactive
steroids
are
new
promising
group
drugs
with
potential
for
use
in
many
diseases
like
postpartum
depression,
postnatal
psychosis,
major
insomnia,
bipolar
disorder,
and
Parkinson’s
tremor,
due
to
their
ability
modulate
activity
GABA
A
receptor.
Neurosteroids
progesterone
metabolites
that
synthesized
cholesterol
or
steroid
hormones
various
brain
regions.
They
regulate
neuronal
development,
regeneration,
neurotransmission.
implicated
mood
disorders,
anxiety
schizophrenia,
PTSD,
impulsive
aggression.
have
been
studied
prevent
treat
neurodegenerative
such
as
Alzheimer’s
disease
HIV-associated
dementia.
can
promote
neurogenesis,
survival,
myelination,
memory
function.
also
affect
growth
sensitivity
hormone-dependent
tumors
gliomas.
Zuranolone,
newly
registered
neurosteroid
drug
has
shown
huge
flexibility
both
clinical
ambulatory
treatment
thanks
its
pharmacokinetic
traits,
especially
possibility
oral
administration,
unlike
predecessor
Brexanolone.
Zuranolone
is
synthetic
positive
allosteric
modulator
GABAA
receptor
be
taken
orally.
The
review
aims
summarize
current
knowledge
on
zuranolone
novel
which
this
was
meant
originally.
It
covers
studies
indexed
PubMed,
Scopus,
Web
Science
databases
published
since
2017.
Keywords
used
search,
well
inclusion
exclusion
criteria,
given
methodology
section.
explains
evidence
role
neurosteroids,
allopregnanolone,
pathophysiology
depression.
discusses
mechanisms
action,
changes
levels
during
pregnancy
postpartum,
trials
brexanolone
zuranolone,
two
analogs
provides
an
overview
biosynthesis
metabolism
neurosteroids
central
peripheral
nervous
system.
Furthermore,
it
different
sources
pathways
production
factors
influence
synthesis
regulation,
stress,
hormones,
drugs,
genetic
variations.
explores
relevance
other
psychiatric
post-traumatic
stress
disorder
(PTSD),
premenstrual
dysphoric
disorder.
Finally,
highlights
associations
between
symptom
severity
effects
modulation
mood,
cognition,
neuroplasticity.
Abstract
Introduction
Globally,
sleep
disturbance
is
the
foremost
public
health
issue
among
pregnant
women
which
might
have
undesirable
birth
outcome
including
neurocognitive
impairment,
preterm
birth,
low
weight,
and
neonatal
morbidity
mortality.
In
Ethiopia,
inconsistent
findings
been
reported
on
prevalence
of
women.
Therefore,
this
review
aims
to
estimate
pooled
its
associated
factors
in
Ethiopia.
Methods
This
systematic
meta-analysis
observational
studies
was
designed
according
PRISMA
guideline.
A
search
literature
conducted
PubMed,
Scopus,
Web
science,
Google
Scholar
using
relevant
searching
key
terms.
The
Newcastle-Ottawa
scale
used
evaluate
quality
all
selected
articles.
Data
were
analyzed
STATA
Version
14
software.
Publication
bias
checked
Egger’s
test
funnel
plot.
Cochran’s
chi-squared
I
2
values
assess
heterogeneity.
fixed-effects
model
applied
during
meta-analysis.
Results
review,
six
included
after
reviewing
17,100
Ethiopia
50.43%
(95%CI:
39.34–61.52).
Third
trimester
pregnancy
AOR
=
4.03;
95%
CI:
2.84,5.71),
multigravidity
(AOR
1.99;
1.54,
2.59),
unplanned
2.56;
1.52,4.31),
depression
3.57;
2.04,
6.27),
stress
2.77;
1.57,
4.88),
anxiety
3.69;
1.42,
9.59)
poor
hygiene
2.49;
1.56,
3.99)
statistically
with
Conclusion
revealed
that
magnitude
woman
relatively
high
multiple
determined
likelihood
having
a
disturbed
sleep-awake
pattern.
Thus,
implementation
interventions
for
screening
needed.
Moreover,
targeted
prevention
unintended
should
be
implemented.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(1), С. 207 - 207
Опубликована: Янв. 2, 2025
Background:
In
the
rooming-in
system,
mothers
and
their
healthy
newborns
stay
together
for
24
h
a
day;
however,
many
women
in
early
postpartum
period
often
find
it
challenging
to
balance
recovery
from
childbirth
with
demands
of
caring
newborns.
This
study
aims
investigate
need
entrust
medical
staff
care,
relationship
this
perceived
pain,
fatigue,
anxiety.
Methods:
The
uses
Need
Entrust
Newborn
under
Care
Staff
(NEN)
scale
Numerical
Rating
Scale
(NRS)
assess
participants’
levels
fatigue
These
scales
were
chosen
provide
comprehensive
assessment
needs
experiences.
Results:
results
reveal
that
among
participants
significantly
high,
an
Me
7.0
(IQR
=
4.0),
exceeding
reportable
both
pain
(Me
6.0,
IQR
5.0)
anxiety
5.0,
6.0)
support
during
day
at
night
was
similar
level
strongly
correlated
(rho
0.723;
p
<
0.001).
Pain
showed
significant
positive
correlation
newborn
0.296;
0.001)
0.332;
During
daytime,
rho
0.423
(p
0.001),
while
overnight,
increased
0.485
Anxiety
support,
daytime
0.422;
overnight
0.431;
Multiparas
reported
lower
(U(Z)
−13.224,
Conclusions:
care
maternity
is
strong
but
unmet
facilities.
Further
research
should
be
conducted
explore
solutions,
plan
future
actions
alleviate
burdens
on
facilitate
recovery.
Nature and Science of Sleep,
Год журнала:
2025,
Номер
Volume 17, С. 261 - 270
Опубликована: Фев. 1, 2025
Objective:
Insomnia
is
a
common
issue
that
pregnant
women
often
have
to
deal
with.
This
study
seeks
examine
the
connections
between
pregnancy
stress,
depressive
symptoms,
family
support,
and
insomnia
symptoms.
Methods:
Convenience
sampling
was
employed
recruit
1049
valid
participants.
The
primary
measurement
tools
utilized
were
Pregnancy
Stress
Scale,
Family
Support
Subscale,
Patient
Health
Questionnaire-2.
Data
analysis
conducted
using
SPSS
24.0
software.
Using
binary
logistic
regression
verify
independent
effects
of
depression
support
on
PROCESS
macro
Model
4
applied
assess
mediating
effect,
while
5
used
evaluate
moderating
effect.
Results:
overall
prevalence
symptoms
among
54%
(n=572)
20%
(n=207)
in
this
study.
positively
affect
indirect
effect
stress
significant,
with
mediator
proportion
45.16%.
As
moderator,
weakens
impact
Conclusion:
Increased
increased
could
trigger
Depressive
mediated
path
from
weakened
link
These
findings
can
assist
managing
more
effectively
improving
their
mental
well-being.
Keywords:
woman
