Disentangling the Genetic Landscape of Peripartum Depression: A Multi-Polygenic Machine Learning Approach on an Italian Sample

Genes, Год журнала: 2024, Номер 15(12), С. 1517 - 1517

Опубликована: Ноя. 26, 2024

Background: The genetic determinants of peripartum depression (PPD) are not fully understood. Using a multi-polygenic score approach, we characterized the relationship between genome-wide information and history PPD in patients with mood disorders, hypothesis that multiple polygenic risk scores (PRSs) could potentially influence development PPD. Methods: We calculated 341 PRSs for 178 parous disorder inpatients affected by major depressive (MDD) or bipolar (BD) (n = 62) without 116) used partial least squares regression novel machine learning pipeline to rank based on their contribution prediction PPD, whole sample separately two diagnostic groups. Results: PLS linear defined model explaining 27.12% variance presence history, 56.73% among MDD, 42.96% BD. Our findings highlight factors related circadian rhythms, inflammation, psychiatric diagnoses top contributors Specifically, contributing PRS was monocyte count, while BD, it chronotype, inflammation significantly both Conclusions: These results confirm previous literature about immune system dysregulation postpartum shed light which involved pathophysiology

Язык: Английский

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Early Life Trauma, Emotion Dysregulation and Hormonal Sensitivity Across Female Reproductive Life Events

Current Psychiatry Reports, Год журнала: 2024, Номер 26(10), С. 530 - 542

Опубликована: Авг. 27, 2024

Язык: Английский

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Risk Factors for Postpartum Depression

V F Snegirev Archives of Obstetrics and Gynecology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 9, 2024

Postpartum depression has recently become an increasingly urgent problem of modern medicine and psychology. Traditionally, this condition is considered as a mental disorder that causes emotional, behavioral physical changes associated with the postpartum period. Despite presence fairly wide range signs, diagnosis still difficult for specialists. A woman experiencing type may find it to realize her on own seek help. However, even if properly diagnosed, very fact having can be negative experience woman. Often, young mothers feel fear or shame in front family members society, hide their diagnosis. This creates additional barriers getting necessary help support. The purpose review was identify analyze risk factors development depressive disorders women period, study some manifestations depression. authors used scientific databases Cyberleninkа, eLibrary PubMed. articles were searched following keywords: "postpartum period", "depressive disorder", depression", factors", "development period". included published over past 5 years. After sampling by annotations keywords, 53 analyzed: 6 Russian speakers 47 English speakers. analyzed all described domestic foreign literature, which classified unmodified modifiable. latter, turn, divided into modifiable mother and/or only health care.

Язык: Английский

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Estradiol and progesterone from pregnancy to postpartum: a longitudinal latent class analysis

Frontiers in Global Women s Health, Год журнала: 2024, Номер 5

Опубликована: Окт. 9, 2024

Introduction During the peripartum, women undergo significant hormonal changes that are crucial for fetal development and a healthy pregnancy postpartum period mother infant. Although several studies have determined norm ranges of estradiol progesterone, there discrepancies among reports, rendering it unclear which hormone levels linked to adverse health outcomes. To account impact sex steroid patterns on outcomes in mothers children, longitudinal assessment different parameters is needed. Materials methods We longitudinally assessed cohort 130 over five months during postpartum. The provided saliva samples completed psychosocial questionnaires. Hormone analyses were conducted using enzyme-linked immunosorbent assay (ELISA). Different progesterone analyzed evaluated relation psychometric variables. examine presence heterogenous trajectories we applied group-based trajectory modelling as special case latent-class group analysis. Results Estradiol rose towards end dropped sharply after birth, with considerable individual variation, particularly pregnancy. However, their ratio remained stable. identified three subgroups two subgroups. Age influenced levels, older pregnant having higher than younger women. Anxiety depressive symptoms had predictive value specific study also revealed distinct regarding course fluctuations well ratio. Conclusion This provides insights into fluctuation salivary peripartum period, highlighting variations but stability this time. finding courses new suggests need further research explore Our preliminary results suggest at appear be normal occurrence might even protective factor associated psychological sleep disturbances

Язык: Английский

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Conventional and new immunotherapies for immune system dysregulation in postpartum mood disorders: comparisons to immune system dysregulations in bipolar disorder, major depression and postpartum autoimmune thyroid disease

Expert Review of Clinical Immunology, Год журнала: 2024, Номер unknown, С. 1 - 23

Опубликована: Окт. 23, 2024

Introduction Postpartum mood disorders are heterogenous and comprise postpartum psychosis depression. Evidence is accumulating that systemic monocyte/macrophage activation, low grade inflammation (premature senescence related) T cell defects increase the risk for outside pregnancy by affecting function of microglia cells in emotional brain (the cortico-limbic system) leading to inadequate regulation upon stress.

Язык: Английский

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Causal associations of Insomnia and postpartum depression: a two-sample mendelian randomization study

Archives of Gynecology and Obstetrics, Год журнала: 2023, Номер 310(3), С. 1409 - 1416

Опубликована: Дек. 19, 2023

Язык: Английский

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Prevalence and associated factors of insomnia symptoms among pregnant women in the third trimester in a moderately developing region of China

BMC Public Health, Год журнала: 2023, Номер 23(1)

Опубликована: Ноя. 23, 2023

Abstract Background Insomnia is the most common sleep disorder in general population, especially among pregnant women, and it considered a major public health issue. Not only can cause mental physical problems but may also affect growth of fetus. However, there are few reports on prevalence influencing factors insomnia symptoms third-trimester women China. The objective this study was to assess third trimester moderately developing region China further explore associated from various aspects. Methods A cross-sectional survey conducted eligible December 2022 February 2023. Data socio-demographic characteristics, clinical behavioral psychological characteristics were collected through structured questionnaire. Chi-square test multivariate logistics regression applied symptoms. Results total 535 included study, 59.8%. Multivariate logistic analysis revealed that who lived together with elders ( OR : 0.58, 95% CI 0.40–0.86), had low perceived stress 0.35–0.97), no threatened abortion 0.55, 0.32–0.93) good doctor-patient communication 0.66, 0.45–0.98) more likely stay away anxiety 2.27, 1.28–4.03), fear childbirth 1.63, 1.11–2.40) high experience COVID-19 1.61, 1.03–2.54) tended have Conclusions Lianyungang city eastern trimester. influenced by multiple factors. There an urgent need develop interventions reduce focus risk for

Язык: Английский

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Sleep disorders during pregnancy - its prevalence, characteristic and neonatal implications

Journal of Education Health and Sport, Год журнала: 2024, Номер 56, С. 157 - 172

Опубликована: Фев. 4, 2024

Introduction and purpose: Each phase of a woman's life, from childhood to menopause, may be associated with variety sleep disturbances. The pregnancy is particularly predisposed develop disorders such as insomnia, restless legs syndrome sleep-disordered breathing, which require special management. This article reviews the most common disturbances in discusses epidemiology, pathophysiology, maternal fetal possible implications therapeutic options pregnant population. Material methods research: search was conducted using PubMed Google Scholarship databases available January 2024. Results: Although exact cause previously mentioned diseases remains uncertain, impact hormonal changes, body mass before weight gaining during gestation on their development highlighted by researchers. Poor have negative outcomes for women well fetuses influence course. These sleeping also contribute other systemic diseases. management disturbance patients challenging due risk teratogenicity, pharmacokinetic changes dynamic nature pregnancy, thus nonpharmacologic interventions should preferred safer than medications. Conclusions: Sleep result poorer quality women’s life condition pregnancy. Thus, this theme create need additional research possibilities prevention treatment strategies women.

Язык: Английский

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Does preterm birth increase the initiation of antidepressant use during the postpartum? A population-based investigation

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Март 27, 2024

Background: Preterm birth may affect maternal mental health. We explored the relationship between preterm and risk of initiating antidepressant use during year after birth. Methods: conducted a population-based investigation using regional healthcare utilization databases. The exposure considered was outcome having at least one prescription for medications used log-binomial regression model including terms age birth, nationality, educational level, parity, modality conception, delivery, other psychotropic drugs, diabetes to estimate relative (RR) 95% confidence intervals (CI) association initiation use. In addition, absolute differences (ARD) were also computed according timing Results: cohort included 727,701 deliveries 2010 2020 in Lombardy, Northern Italy. Out these, 6,522 (0.9%) women had drugs births related 38% increased (adjusted RR = 1.38; CI: 1.25–1.52) moderate late 83% 1.83; 1.46–2.28) extremely very preterm. Excluding with only prescription, consistent 1.41, 95%CI: 1.23–1.61 adjusted 1.81, 1.31–2.49 preterm). Also, excluding who psychotropics, remained 1.39, 1.26–1.54 1.91, 1.53–2.38, respectively Conclusion: Women delivered have an excess consumption first

Язык: Английский

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Psychometric Properties of the Healthy Lifestyle Behaviors Scale in Portuguese Pregnant Women

Western Journal of Nursing Research, Год журнала: 2024, Номер 46(6), С. 428 - 435

Опубликована: Апрель 14, 2024

Background: Pregnancy provides a privileged and opportune moment to implement interventions promoting healthy lifestyle behaviors significantly improving perinatal outcomes. The Healthy Lifestyle Behaviors Scale (HLBES) can be used assess health behaviors, such as diet, physical activity, mental health. Purpose: This study aimed examine the psychometric properties of HLBES in Portuguese pregnant women. Methods: A methodological was conducted on convenience sample 192 women receiving prenatal care. After cross-cultural adaptation, an exploratory factor analysis internal consistency assessment were carried out evaluate scale. Data collected included Beliefs HLBES’ criterion validity. Results: Exploratory with Varimax rotation yielded 2 subscales that explained 45.23% total variance. scale revealed overall 0.78 good validity ( r = 0.65, P < .01). Conclusion: Our results suggest is instrument for reporting women; however, further studies are recommended. not only describe but also determine effects interventions.

Язык: Английский

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