Brain,
Год журнала:
2023,
Номер
146(10), С. 3969 - 3990
Опубликована: Май 15, 2023
Results
from
recent
clinical
trials
of
antibodies
that
target
amyloid-β
(Aβ)
for
Alzheimer's
disease
have
created
excitement
and
been
heralded
as
corroboration
the
amyloid
cascade
hypothesis.
However,
while
Aβ
may
contribute
to
disease,
genetic,
clinical,
imaging
biochemical
data
suggest
a
more
complex
aetiology.
Here
we
review
history
weaknesses
hypothesis
in
view
new
evidence
obtained
anti-amyloid
antibodies.
These
indicate
treatments
either
no
or
uncertain
effect
on
cognition.
Despite
importance
definition
argue
point
playing
minor
aetiological
role.
We
also
discuss
suggesting
concerted
activity
many
pathogenic
factors
propose
evolving
multi-factor
models
will
better
underpin
search
effective
strategies
treat
disease.
Current Neuropharmacology,
Год журнала:
2013,
Номер
11(4), С. 338 - 378
Опубликована: Июнь 1, 2013
Curcumin
(diferuloylmethane),
a
polyphenol
extracted
from
the
plant
Curcuma
longa,
is
widely
used
in
Southeast
Asia,
China
and
India
food
preparation
for
medicinal
purposes.
Since
second
half
of
last
century,
this
traditional
medicine
has
attracted
attention
scientists
multiple
disciplines
to
elucidate
its
pharmacological
properties.
Of
significant
interest
curcumin's
role
treat
neurodegenerative
diseases
including
Alzheimer's
disease
(AD),
Parkinson's
(PD)
malignancy.
These
all
share
an
inflammatory
basis,
involving
increased
cellular
reactive
oxygen
species
(ROS)
accumulation
oxidative
damage
lipids,
nucleic
acids
proteins.
The
therapeutic
benefits
curcumin
these
appear
multifactorial
via
regulation
transcription
factors,
cytokines
enzymes
associated
with
(Nuclear
factor
kappa
beta)
NFκB
activity.
This
review
describes
historical
use
medicine,
chemistry,
stability
biological
activities,
anti-cancer,
anti-microbial,
anti-oxidant,
anti-inflammatory
further
discusses
pharmacology
provides
new
perspectives
on
potential
limitations.
Especially,
focuses
detail
effectiveness
mechanism
actions
treating
such
as
brain
malignancies.
Analytical Chemistry,
Год журнала:
2013,
Номер
85(11), С. 5595 - 5599
Опубликована: Май 7, 2013
A
highly
efficient
fluorosensor
based
on
ultrathin
graphitic
carbon
nitride
(g-C3N4)
nanosheets
for
Cu2+
was
developed.
In
the
absence
of
metal
ions,
exhibit
high
fluorescence;
strong
coordination
Lewis
basic
sites
them
to
however,
causes
fluorescence
quenching
via
photoinduced
electron
transfer
leading
qualitative
and
semiquantitative
detection
ions.
This
exhibits
selectivity
toward
Cu2+.
The
whole
process
can
be
completed
within
10
min
with
a
limit
as
low
0.5
nM.
use
test
paper
enables
naked-eye
0.1
nmol.
practical
this
sensor
determination
in
real
water
samples
also
demonstrated.
International Journal of Alzheimer s Disease,
Год журнала:
2011,
Номер
2011(1)
Опубликована: Янв. 1, 2011
Whilst
being
environmentally
abundant,
aluminum
is
not
essential
for
life.
On
the
contrary,
a
widely
recognized
neurotoxin
that
inhibits
more
than
200
biologically
important
functions
and
causes
various
adverse
effects
in
plants,
animals,
humans.
The
relationship
between
exposure
neurodegenerative
diseases,
including
dialysis
encephalopathy,
amyotrophic
lateral
sclerosis
Parkinsonism
dementia
Kii
Peninsula
Guam,
Alzheimer's
disease
(AD)
has
been
suggested.
In
particular,
link
subject
of
scientific
debate
several
decades.
However,
complex
characteristics
bioavailability
make
it
difficult
to
evaluate
its
toxicity
therefore,
remains
be
established.
Mounting
evidence
suggested
significance
oligomerization
β-amyloid
protein
neurotoxicity
molecular
mechanism
AD
pathogenesis.
Aluminum
may
play
crucial
roles
as
cross-linker
oligomerization.
Here,
we
review
detailed
based
on
our
own
studies
recent
literatures.
Our
aim
revisit
integrate
amyloid
cascade
hypotheses
context
interactions
with
other
metals.
Chemical Society Reviews,
Год журнала:
2014,
Номер
43(19), С. 6727 - 6749
Опубликована: Янв. 1, 2014
Metals
are
functionally
essential,
but
redistribute
in
neurodegenerative
disease
where
they
induce
protein
aggregates,
catalyze
radical
formation,
and
lose
bioavailability.
Dementia
risk
reduction
is
a
major
and
growing
public
health
priority.
While
certain
modifiable
factors
for
dementia
have
been
identified,
there
remains
substantial
proportion
of
unexplained
risk.
There
evidence
that
environmental
may
explain
some
this
Thus,
we
present
the
first
comprehensive
systematic
review
dementia.We
searched
PubMed
Web
Science
databases
from
their
inception
to
January
2016,
bibliographies
articles,
articles
related
publically
available
data.
Articles
were
included
if
they
examined
association
between
an
factor
dementia.
Studies
with
another
outcome
(for
example,
cognition),
physiological
measure
exposure,
case
studies,
animal
studies
nutrition
excluded.
Data
extracted
individual
which
were,
in
turn,
appraised
methodological
quality.
The
strength
consistency
overall
each
identified
was
assessed.We
screened
4784
60
review.
Risk
considered
six
categories:
air
quality,
toxic
heavy
metals,
other
trace
elements,
occupational-related
exposures,
miscellaneous
factors.
Few
took
life
course
approach.
at
least
moderate
implicating
following
factors:
pollution;
aluminium;
silicon;
selenium;
pesticides;
vitamin
D
deficiency;
electric
magnetic
fields.Studies
varied
widely
size
quality
therefore
must
be
circumspect
our
conclusions.
Nevertheless,
extensive
suggests
future
research
could
focus
on
short
list
Furthermore,
further
robust,
longitudinal
repeated
measures
exposures
are
required
confirm
these
associations.
