Scientific evidence available after 18 years of application of fibrin rich in platelets and leukocytes in the repair of surgical wounds: An integrative review DOI Creative Commons

Karolayne Dutra Félix,

Milene dos Santos Madeiro,

Josemar Pereira Dos Passos Júnior

и другие.

Brazilian Journal of Implantology and Health Sciences, Год журнала: 2024, Номер 6(8), С. 3902 - 3916

Опубликована: Авг. 23, 2024

Introduction: In the last 18 years, Platelet and Leukocyte Rich Fibrin (L-PRF) has emerged as an innovative biomaterial in regenerative medicine dentistry, standing out for its ability to continuously release growth factors promote more efficient healing. However, variability preparation application of L-PRF, together with lack standardization, represent major challenges, increasing need further research improve standardize clinical use. Materials Methods: This study is integrative review, no submit it Research Ethics Committee. The guiding question was: “What main evidence literature on applications platelet- leukocyte-rich fibrin dentistry?”. Results Discussion: L-PRF proved effective various areas dentistry. implantology, accelerates bone healing improves implant integration. periodontics, promotes regeneration damage quality periodontal tissue. gingival recessions soft tissue lesions, reduces post-operative discomfort. maxillofacial surgery, contributes a faster comfortable recovery from swelling pain. Variability still challenge, standardization protocols essential ensure consistent predictable results. Conclusion: After shown beneficial effects especially terms improved seems be crucial order

Язык: Английский

Apicoectomy versus apical curettage in combination with or without L-PRF application: a randomized clinical trial DOI Creative Commons
Serap Gülsever, Şeyda Erşahan, Yelda Erdem Hepşenoğlu

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 8, 2025

This study compared the efficacy of apicoectomy and apical curettage with without leukocyte- platelet-rich fibrin (L-PRF) in treating large periapical lesions. Sixty-four adults (30 male, 34 female) a previously endodontically treated tooth lesion were randomized into four groups (n = 16): retrograde obturation (RG), orthograde (OG), RG + L-PRF, OG L-PRF. All participants underwent root canal retreatment two sessions. The group root-end resection MTA obturation, L-PRF application to bone defect following protocol, resection, protocol. Clinical radiographic assessments performed preoperatively, at 1 week 1, 3, 6, 9, 12 months postoperatively. At follow-up visits, pain scores, swelling, mobility, tenderness percussion (T-PER), palpation (T-PAL), presence fistula clinically assessed. Periapical radiography determined index (PAI) score measured area (PALA). Kruskal–Wallis test was effect single independent variable (factor) on dependent variable. No statistically significant differences identified between for preoperative PAI fistula, T-PER, or T-PAL (p > 0.05). postoperative showed significantly lower T-PER. PALA values higher healing rates 9 months. Both achieved over 90% It concluded that combination effectively treats lesions promotes both short- long-term offers less invasive alternative, especially when crown-to-root ratio is concern. Trial registration: protocol registered ClinicalTrials.gov (NCT05847647).

Язык: Английский

Процитировано

0

Histomorphometric and microtomographic evaluation of hydroxyapatite coated implants and L-PRF in over drilled bone sites in sheep DOI Creative Commons
Sylvio Luiz Costa de Moraes,

Fernando Lima,

Suelen Cristina Sartoretto

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 28, 2025

Hydroxyapatite used as a coating for titanium dental implants reduces the time required osseointegration. Platelet-rich fibrin (L-PRF) releases growth factors and cytokines, enhancing tissue healing bone regeneration. This study aimed to evaluate histologically, histomorphometrically, by microcomputed tomography an implant surface coated with nanostructured hydroxyapatite (HAnano), in comparison double acid-etched (DAA) surface, both without peri-implant grafting L-PRF, installed over-instrumented sites low-density bone. Five adult sheep (2-4 years old) received twenty 3.5 × 10 mm iliac crest. Bone-to-implant contact (BIC) bone-occupied area fraction (BAFo) were evaluated histomorphometrically after 8-week experimental period. Brown-Forsyth analysis of variance (ANOVA) Welch's ANOVA test did not identify significant differences between groups. On average, BIC ranged from 44% (HAnano + L-PRF) 63% (DAA L-PRF). µCT revealed that volume density region 26% 39% (DAA). No statistically observed Both surfaces studied allowed osseointegration low sites, independently 8 weeks implantation. While this model provided controlled conditions evaluating early-stage osseointegration, absence functional loading relatively short follow-up period should be considered when extrapolating findings clinical applications. Future studies assess these variables under load-bearing extended observation periods. All remained alive.

Язык: Английский

Процитировано

0

PRF and PRP in Dentistry: An Umbrella Review DOI Open Access
Alfonso Acerra,

Mario Caggiano,

Andrea Chiacchio

и другие.

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(9), С. 3224 - 3224

Опубликована: Май 6, 2025

Introduction: Platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) utilize autologous blood share the objective of leveraging blood-derived growth factors to enhance body’s natural healing process. A large extensive use has been made in various branches dentistry. Methods: total 4175 records were identified from electronic search, specifically 291 BioMed Central, 3406 MEDLINE/PubMed, 304 Cochrane library databases, 174 PROSPERO register. This review was performed relation PRISMA flow chart annotated Results: In total, 3416 title abstracts screened, a 40 systematic reviews finally included present umbrella review. Conclusions: Research supports PRF PRP different fields is huge potential for patient but also doctor as these products are have zero cost. However, further studies needed, especially RCTs, clearer evidence on role PRP.

Язык: Английский

Процитировано

0

Innovative Approach for Dental Socket Healing Using PRF-Enriched Metal Nanocomposites – A Comprehensive Review DOI

P Rajesh,

Jino Affrald R, Shoba Narayan

и другие.

Journal of Oral and Maxillofacial Surgery Medicine and Pathology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Scientific evidence available after 18 years of application of fibrin rich in platelets and leukocytes in the repair of surgical wounds: An integrative review DOI Creative Commons

Karolayne Dutra Félix,

Milene dos Santos Madeiro,

Josemar Pereira Dos Passos Júnior

и другие.

Brazilian Journal of Implantology and Health Sciences, Год журнала: 2024, Номер 6(8), С. 3902 - 3916

Опубликована: Авг. 23, 2024

Introduction: In the last 18 years, Platelet and Leukocyte Rich Fibrin (L-PRF) has emerged as an innovative biomaterial in regenerative medicine dentistry, standing out for its ability to continuously release growth factors promote more efficient healing. However, variability preparation application of L-PRF, together with lack standardization, represent major challenges, increasing need further research improve standardize clinical use. Materials Methods: This study is integrative review, no submit it Research Ethics Committee. The guiding question was: “What main evidence literature on applications platelet- leukocyte-rich fibrin dentistry?”. Results Discussion: L-PRF proved effective various areas dentistry. implantology, accelerates bone healing improves implant integration. periodontics, promotes regeneration damage quality periodontal tissue. gingival recessions soft tissue lesions, reduces post-operative discomfort. maxillofacial surgery, contributes a faster comfortable recovery from swelling pain. Variability still challenge, standardization protocols essential ensure consistent predictable results. Conclusion: After shown beneficial effects especially terms improved seems be crucial order

Язык: Английский

Процитировано

0