Self-DNA driven inflammation in COVID-19 and after mRNA-based vaccination: lessons for non-COVID-19 pathologies DOI Creative Commons
Martin Heil

Frontiers in Immunology, Год журнала: 2024, Номер 14

Опубликована: Фев. 19, 2024

The coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented concentration of economic and research efforts to generate knowledge at unequalled speed on deregulated interferon type I signalling nuclear factor kappa light chain enhancer in B-cells (NF-κB)-driven interleukin (IL)-1β, IL-6, IL-18 secretion causing cytokine storms. translation the how resulting systemic inflammation can lead life-threatening complications into novel treatments vaccine technologies is underway. Nevertheless, previously existing role cytoplasmatic or circulating self-DNA as a pro-inflammatory damage-associated molecular pattern (DAMP) was largely ignored. Pathologies reported ‘ de novo ’ for patients infected with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 be outcomes self-DNA-driven fact had been linked earlier different contexts, e.g., infection Human Immunodeficiency Virus (HIV)-1, sterile inflammation, autoimmune diseases. highlight particularly synergies other DAMPs render immunogenic properties normally non-immunogenic extracellular self-DNA, discuss shared features gp41 unit HIV-1 envelope protein SARS-CoV 2 Spike that enable SARS-CoV-2 interact cell membranes, trigger syncytia formation, inflict damage their host’s DNA, – likely own benefit. These similarities motivate speculations similar mechanisms those driven by explain inflammatory contributes some most frequent adverse events after vaccination BNT162b2 mRNA (Pfizer/BioNTech) mRNA-1273 (Moderna) vaccine, i.e., myocarditis, herpes zoster, rheumatoid arthritis, nephritis hepatitis, new-onset lupus erythematosus, flare-ups psoriasis lupus. hope wider application lessons learned from experiences COVID-19 new vaccines combat future non-COVID-19

Язык: Английский

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA): past, present, and future implications DOI Creative Commons

Isa Seida,

Mahmoud Alrais,

Ravend Seida

и другие.

Clinical & Experimental Immunology, Год журнала: 2023, Номер 213(1), С. 87 - 101

Опубликована: Март 7, 2023

Summary Adjuvants, as the name indicates, are adjoined material aimed to assist in functioning when added vaccines they meant boost effect and strongly stimulate immune system. The response of system can be unpredictable, autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was developed address possible adverse reactions an autoimmune inflammatory type that may caused adjuvants. While ASIA, a syndrome, coined defined 2011; reports describing patients with vague nonspecific clinical symptoms following vaccinations appeared much earlier. In other words, ASIA came define, arrange, unite variety symptoms, related autoimmunity, not vaccine itself, rather adjuvant part such aluminum, among others. Accordingly, introduction enabled better understanding, proper diagnosis, early treatment disorder. Furthermore, shown associated almost all body systems various rheumatic diseases systemic lupus erythematosus, antiphospholipid sclerosis. addition, correlation between COVID-19 noticed during pandemic. this review, we summarized reported effects medical literature before after defined, several ways manifest impact different body, incidences It is important clarify, among, if the, most effective means fighting infectious however, believe manufacturing above criticism, particularly it comes substances possessing risk side effects.

Язык: Английский

Процитировано

18
Pilot Findings on SARS-CoV-2 Vaccine-Induced Pituitary Diseases: A Mini Review from Diagnosis to Pathophysiology DOI Creative Commons
Taïeb Ach, M. El Euch

Vaccines, Год журнала: 2022, Номер 10(12), С. 2004 - 2004

Опубликована: Ноя. 24, 2022

Since the emergence of COVID-19 pandemic at end 2019, a massive vaccination campaign has been undertaken rapidly and worldwide. Like other vaccines, vaccine is not devoid side effects. Typically, adverse effects include transient headache, fever, myalgia. Endocrine organs are also affected by The major SARS-CoV-2 vaccine-associated endocrinopathies reported since beginning thyroid pancreas disorders. vaccine-induced pituitary diseases have become more frequently described in literature. We searched PubMed/MEDLINE for commentaries, case reports, series articles reporting disorders following vaccination. search was reiterated until September 2022, which eight reports were found. In all cases, there no personal or familial history disease described. All patients had previous infection prior to episode. Regarding type vaccines administered, 50% received (BNT162b2; Pfizer–BioNTech) (ChAdOx1 nCov-19; AstraZeneca). five disorder developed after first dose corresponding vaccine. types disorder, hypophysitis (variable clinical aspects ranging from lesion stalk thickness) three apoplexy. time period between ranged one seven days. Depending on each case’s follow-up time, complete remission obtained apoplexy cases but only with (persistence central diabetes insipidus). Both quantity quality published data about inconveniences limited. Pituitary disorders, unlike occur very quickly (less than days versus two months disease). This partially explained ease reaching pituitary, small gland. Therefore, this gland overspread, explains speed onset symptoms (especially ADH deficiency rapid deficit evocative symptoms). Accordingly, these pilot findings offer clinicians future direction be vigilant possible will allow them accurately orient medical assistance when they present remarkable symptoms, such as asthenia, polyuro-polydipsia, severe

Язык: Английский

Процитировано

28
New-onset systemic vasculitis following SARS-CoV-2 infection and vaccination: the trigger, phenotype, and outcome DOI

Prakashini MV,

Akerke Auanassova, Marlen Yessirkepov

и другие.

Clinical Rheumatology, Год журнала: 2023, Номер 42(10), С. 2761 - 2775

Опубликована: Июль 8, 2023

Язык: Английский

Процитировано

17
Risk of autoimmune skin and connective tissue disorders after mRNA-based COVID-19 vaccination DOI Open Access
Hyun Jeong Ju, Ju Yeong Lee, Ju Hee Han

и другие.

Journal of the American Academy of Dermatology, Год журнала: 2023, Номер 89(4), С. 685 - 693

Опубликована: Май 15, 2023

Язык: Английский

Процитировано

15
Chronic Fatigue and Dysautonomia following COVID-19 Vaccination Is Distinguished from Normal Vaccination Response by Altered Blood Markers DOI Creative Commons

Amelie Semmler,

Anna Katharina Mundorf,

Anna Sabrina Kuechler

и другие.

Vaccines, Год журнала: 2023, Номер 11(11), С. 1642 - 1642

Опубликована: Окт. 26, 2023

SARS-CoV-2 mRNA vaccination can entail chronic fatigue/dysautonomia tentatively termed post-acute COVID-19 syndrome (PACVS). We explored receptor autoantibodies and interleukin-6 (IL-6) as somatic correlates of PACVS. Blood markers determined before six months after first-time healthy controls (N = 89; 71 females; mean/median age: 39/49 years) were compared with corresponding values PACVS-affected persons 191; 159 40/39 exhibiting (≥three symptoms for ≥five the last vaccination) not due to infection and/or confounding diseases/medications. Normal response encompassed decreases in 11 antibodies (by 25–50%, p < 0.0001), increases two 15–25%, 0.0001) normal IL-6. In PACVS, serological vaccination–response appeared significantly (p altered, allowing discrimination from post-vaccination state (sensitivity 90%, by increased Angiotensin II type 1 (cut-off ≤ 10.7 U/mL, ROC-AUC 0.824 ± 0.027), decreased alpha-2B adrenergic ≥ 25.2 0.828 0.025) IL-6 2.3 pg/mL, 0.850 0.022). PACVS is thus indicated a delineated/detectable diagnostic blood markers.

Язык: Английский

Процитировано

15
Vaccines and Autoimmunity—From Side Effects to ASIA Syndrome DOI Creative Commons

Isa Seida,

Ravend Seida, Abdulrahman Elsalti

и другие.

Medicina, Год журнала: 2023, Номер 59(2), С. 364 - 364

Опубликована: Фев. 14, 2023

Since vaccines are in fact manufactured chemical compounds such as drugs, the appearance of side effects following their use is not surprising. Similarly, main goal to stimulate immune system bringing out production protective antibodies, autoimmune-related a consequence increased activity do seem irrational. Fortunately, rate low; however, importance reporting adverse events vaccinations, understanding mechanisms behind appearance, making early diagnosis, and appropriate treatment cannot be overemphasized. In fact, vaccines, particularly those based on adjuvants, were reported long before introduction autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Nevertheless, ASIA gathered united under one title, step which helped organize research call for better stimulators than adjuvants. New technologies methods clearly noticed during pandemic COVID-19 after mRNA-based vaccines. our current paper, we introduce notion autoimmune nature, ASIA, linked with including recent The transition from idea work.

Язык: Английский

Процитировано

14
Endocrine system after 2 years of COVID-19 vaccines: A narrative review of the literature DOI Creative Commons
Letizia Chiara Pezzaioli, Elisa Gatta, Francesca Bambini

и другие.

Frontiers in Endocrinology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 10, 2022

Purpose The purpose of this study was to describe the current knowledge on potential endocrine adverse effects post-COVID-19 vaccines. Methods A PubMed/MEDLINE, Web Science, and Scopus research performed. Case reports, case series, original studies, reviews written in English published online up 31 July 2022 were selected reviewed. final reference list defined based relevance each paper scope review. Results available data showed that side are generally rare with favorable outcome, being thyroid disorders most common. Conversely, type 1 diabetes mellitus rare; adrenal pituitary events even anecdotal. Finally, clinical studies suggest no impact female reproductive system male couple fertility. Conclusion Overall, these show that, after 2 years COVID-19 vaccines, is not heavily threatened.

Язык: Английский

Процитировано

22
The mosaic of autoimmunity – Finally discussing in person. The 13th international congress on autoimmunity 2022 (AUTO13) Athens DOI Open Access
Naim Mahroum, Abdulrahman Elsalti, Abdulkarim Alwani

и другие.

Autoimmunity Reviews, Год журнала: 2022, Номер 21(10), С. 103166 - 103166

Опубликована: Авг. 4, 2022

Язык: Английский

Процитировано

20
Central diabetes insipidus: a late sequela of BNT162b2 SARS-CoV-2 mRNA vaccine? DOI Creative Commons
Avraham Ishay, Elena Chertok Shacham

BMC Endocrine Disorders, Год журнала: 2023, Номер 23(1)

Опубликована: Фев. 22, 2023

Abstract Background The development of an effective vaccine is a powerful tool to contain the global spread coronavirus disease 2019 (COVID-19). Still, it raises potential safety concerns about subsequent enhancement associated immunopathology. Increasing evidence shows that endocrine system, including hypophysis, may be involved in COVID-19. Moreover, occasional but increasing reports disorders involving thyroid have been reported after severe acute respiratory syndrome 2 (SARS-CoV-2) vaccine. Among them, few cases encompass pituitary. Here we report rare case central diabetes insipidus following SARS-CoV-2 vaccination. Case presentation We 59-year-old female patient with 25-year history Crohn's long-term remission, who presented sudden onset polyuria eight weeks administration mRNA Laboratory evaluation was consistent isolated insipidus. Magnetic resonance imaging displayed involvement infundibulum and posterior hypophysis. Eighteen months vaccination, she still under desmopressin treatment had stable pituitary stalk thickening on magnetic imaging. Although disease-associated hypophysitis has reported, scarce. In absence other recognizable causes hypophysitis, believe hypophysis our triggered by Conclusions potentially Further studies are needed understand better mechanisms underlying autoimmune endocrinopathies context COVID-19 infection

Язык: Английский

Процитировано

12
New-onset of rheumatic diseases following COVID-19 vaccination: the report of three cases and a literature review DOI Creative Commons

Mayumi Matsuda,

Yu Asanuma,

Kyohei Emoto

и другие.

Immunological Medicine, Год журнала: 2024, Номер 47(3), С. 205 - 216

Опубликована: Апрель 16, 2024

Vaccines against coronavirus disease 2019 (COVID-19) have been distributed in most countries for the prevention of onset and aggravation COVID-19. Recently, there increasing numbers reports on new-onset autoimmune autoinflammatory diseases following COVID-19 vaccination, however, only little information is available long-term safety these vaccines. Here, we experienced three cases rheumatic one case each rheumatoid arthritis (RA), anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) systemic lupus erythematosus (SLE). The symptom ranged from day to a few days vaccination. patients AAV SLE were treated successfully with glucocorticoid therapy, patient RA died due In literature review which including seven RA, 37 18 SLE, mean time vaccination was approximately 11 12 days. Most improved glucocorticoid, immunosuppressive drugs biologic agents. Although such adverse effects are rare, vaccines useful prevent severity infections, continued accumulation similar important terms examining understanding pathogenic mechanism diseases.

Язык: Английский

Процитировано

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