Thymol Alleviates Colitis by Modulating Intestinal Barrier Damage, Gut Microbiota, and Amino Acid Metabolic Pathways DOI
Ziwen Ma, Xin Wen, Yahan Zhang

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Thymol (THY) is a phenolic monoterpene compound that has garnered attention due to its various biological properties, including antioxidant, anti-inflammatory, and immune-regulatory effects. The purpose of this study was determine the therapeutic protective effects THY in colitic mice, with particular focus on mechanisms involving gut microbiota. results showed early intervention (40 80 mg/kg) not only alleviated clinical symptoms colonic damage mice dextran sodium sulfate (DSS)-induced colitis but also suppressed production inflammatory cytokines (IL-1β, IL-6, IL-18) enhanced expression mucins (MUC1 MUC2) trefoil factor family 3 (TFF3), thereby improving integrity intestinal epithelial barrier. In addition, altered composition microbiota by increasing abundance Bacteroides reducing Proteobacteria. Fecal microbial transplantation (FMT) demonstrated FM from donor significantly improved bowel disease (IBD), confirming crucial role Metagenomic untargeted metabolomic studies found characteristic Prevotellaceae, upregulated amino acid metabolic pathways related arginine proline metabolism, biosynthesis, glycerophospholipid metabolism. summary, holds significant potential as functional additive enhance host activity.

Язык: Английский

Thymol Alleviates Colitis by Modulating Intestinal Barrier Damage, Gut Microbiota, and Amino Acid Metabolic Pathways DOI
Ziwen Ma, Xin Wen, Yahan Zhang

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Thymol (THY) is a phenolic monoterpene compound that has garnered attention due to its various biological properties, including antioxidant, anti-inflammatory, and immune-regulatory effects. The purpose of this study was determine the therapeutic protective effects THY in colitic mice, with particular focus on mechanisms involving gut microbiota. results showed early intervention (40 80 mg/kg) not only alleviated clinical symptoms colonic damage mice dextran sodium sulfate (DSS)-induced colitis but also suppressed production inflammatory cytokines (IL-1β, IL-6, IL-18) enhanced expression mucins (MUC1 MUC2) trefoil factor family 3 (TFF3), thereby improving integrity intestinal epithelial barrier. In addition, altered composition microbiota by increasing abundance Bacteroides reducing Proteobacteria. Fecal microbial transplantation (FMT) demonstrated FM from donor significantly improved bowel disease (IBD), confirming crucial role Metagenomic untargeted metabolomic studies found characteristic Prevotellaceae, upregulated amino acid metabolic pathways related arginine proline metabolism, biosynthesis, glycerophospholipid metabolism. summary, holds significant potential as functional additive enhance host activity.

Язык: Английский

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