Collective intelligence: A unifying concept for integrating biology across scales and substrates

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Март 28, 2024

Abstract A defining feature of biology is the use a multiscale architecture, ranging from molecular networks to cells, tissues, organs, whole bodies, and swarms. Crucially however, not only nested structurally, but also functionally: each level able solve problems in distinct problem spaces, such as physiological, morphological, behavioral state space. Percolating adaptive functionality one competent subunits higher functional organization requires collective dynamics: multiple components must work together achieve specific outcomes. Here we overview number biological examples at different scales which highlight ability cellular material make decisions that implement cooperation toward homeodynamic endpoints, intelligence by solving cell, tissue, whole-organism levels. We explore hypothesis province groups animals, an important symmetry exists between science swarms competencies cells other systems scales. then briefly outline implications this approach, possible impact tools field diverse for regenerative medicine synthetic bioengineering.

Язык: Английский

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Future medicine: from molecular pathways to the collective intelligence of the body

Trends in Molecular Medicine, Год журнала: 2023, Номер 29(9), С. 687 - 710

Опубликована: Июль 20, 2023

The remarkable anatomical homeostasis exhibited by complex living organisms suggests that they are inherently reprogrammable information-processing systems offer numerous interfaces to their physiological and problem-solving capacities. We briefly review data suggesting the multiscale competency of forms affords a new path for biomedicine exploits innate collective intelligence tissues organs. concept tissue-level allostatic goal-directedness is already bearing fruit in clinical practice. sketch roadmap towards 'somatic psychiatry' using advances bioelectricity behavioral neuroscience design methods induce self-repair structure function. Relaxing assumption cellular control mechanisms static, exploiting powerful concepts from cybernetics, science, developmental biology may spark definitive solutions current biomedical challenges.

Язык: Английский

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Aging as a loss of morphostatic information: A developmental bioelectricity perspective

Ageing Research Reviews, Год журнала: 2024, Номер 97, С. 102310 - 102310

Опубликована: Апрель 17, 2024

Язык: Английский

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Life, its origin, and its distribution: a perspective from the Conway-Kochen Theorem and the Free Energy Principle

Communicative & Integrative Biology, Год журнала: 2025, Номер 18(1)

Опубликована: Фев. 17, 2025

We argue here that the Origin of Life (OOL) problem is not just a chemistry but also, and primarily, cognitive science problem. When interpreted through lens Conway-Kochen theorem Free Energy Principle, contemporary physics characterizes all complex dynamical systems persist time as Bayesian agents. If persistent are to some – perhaps only minimal extent cognitive, alive, or living subset systems? no bright line can be drawn, we re-assess, from this perspective, Fermi paradox Drake equation. conclude improving our abilities recognize communicate with diverse intelligences in embodiments, whether based on familiar biochemistry not, will either resolve obviate OOL

Язык: Английский

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The role of ribosomal protein networks in ribosome dynamics

Nucleic Acids Research, Год журнала: 2025, Номер 53(1)

Опубликована: Янв. 7, 2025

Accurate protein synthesis requires ribosomes to integrate signals from distant functional sites and execute complex dynamics. Despite advances in understanding ribosome structure function, two key questions remain: how information is transmitted between these sites, ribosomal movements are synchronized? We recently highlighted the existence of networks, likely evolved participate signaling. Here, we investigate relationship networks Our findings show that major motion centers bacterial interact specifically with r-proteins, RNA exhibits high mobility around each r-protein. This suggests periodic electrostatic changes context negatively charged residues (Glu Asp) induce RNA-protein 'distance-approach' cycles, controlling during translocation. These play a critical role modulating repulsion proteins, thus coordinating propose r-protein synchronize dynamics through an 'electrostatic domino' effect, extending concept allostery regulation within supramolecular assemblies.

Язык: Английский

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AI-driven automated discovery tools reveal diverse behavioral competencies of biological networks

eLife, Год журнала: 2025, Номер 13

Опубликована: Янв. 13, 2025

Many applications in biomedicine and synthetic bioengineering rely on understanding, mapping, predicting, controlling the complex behavior of chemical genetic networks. The emerging field diverse intelligence investigates problem-solving capacities unconventional agents. However, few quantitative tools exist for exploring competencies non-conventional systems. Here, we view gene regulatory networks (GRNs) as agents navigating a problem space develop automated to map robust goal states GRNs can reach despite perturbations. Our contributions include: (1) Adapting curiosity-driven exploration algorithms from AI discover range reachable GRNs, (2) Proposing empirical tests inspired by behaviorist approaches assess their navigation competencies. data shows that models inferred biological wide spectrum steady states, exhibiting various physiological network dynamics without requiring structural changes properties or connectivity. We also explore applicability these ‘behavioral catalogs’ comparing evolved across networks, designing drug interventions biomedical contexts bioengineering. These emphasis behavior-shaping open new paths efficiently For interactive version this paper, please visit https://developmentalsystems.org/curious-exploration-of-grn-competencies .

Язык: Английский

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Thoughts and thinkers: On the complementarity between objects and processes

Physics of Life Reviews, Год журнала: 2025, Номер 52, С. 256 - 273

Опубликована: Янв. 18, 2025

Язык: Английский

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Developmental Bioelectricity as an Explanatory Framework for Cognition and Meaning

Biosemiotics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Язык: Английский

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Artificial Intelligences: A Bridge Toward Diverse Intelligence and Humanity's Future

Advanced Intelligent Systems, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Recent discussions and debate around artificial intelligence (AI) its status are notably incomplete, missing the implications of highly relevant aspects emerging fields diverse (DI) synthetic morphology, as well basic facts developmental biology. Herein, it is argued that human flourishing impossible without an appreciation space possible beings ways in which today's intelligent machine debates about universal existential questions facing biological beings, not just AI. The inevitable arrival a wide set unconventional bodies minds humans modify create new forms will disrupt untenable old narratives what people how to recognize their sentient allies unfamiliar guises. issues engendered by advent AI from perspective field DI evolutionary history discussed.

Язык: Английский

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Thermodynamics, Infodynamics and Emergence

Qeios, Год журнала: 2023, Номер unknown

Опубликована: Июль 5, 2023

Emergence of novel processes, properties, structures, and systems is a poorly understood phenomenon. Emergence, information energy are interrelated properties nature: it takes free (energy that produces work, designed as F) to acquire information, increment energy. Useful (Φ), the one increases energy, differs from not producing or entropy. Energy obeys all laws thermodynamics, while may not. When interact, levels emerge. Information can reveal itself in different forms (as entropy, order, complexity, physically encoded, mechanical, biological, structural, neural social networks, etc.). increase by reducing entropy an open system, capturing surroundings. The dynamics has been studied mostly physical-chemistry engineering. Now we find everywhere, including computer sciences, genetics, biotechnology, experimental law. In emergent new possibilities increasing useful appear. Emergent complexity visible transitions subatomic particles atoms, atoms molecules, cells, organisms, societies ecosystems. A law for irreversible thermodynamics stating ΔF ~ ΔΦ, evidenced empirically these confirming INCREASES IN USEFUL INFORMATION AND INCREMENTS FREE ENERGY ARE COUPLED. As helps access more evolution natural selection accumulates ever giving birth life. contrast, decreases might affect amount available system. More noise misleading which These relationships help us understand life, societies, ecosystems, autonomous artificial Quantifying concomitant changes needed relationship between them. endeavor achieve this begun (Jaffe 2023 [https://www.qeios.com/read/2VWCJG.5]).

Язык: Английский

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