Neuronal injuries in cerebral infarction and ischemic stroke: From mechanisms to treatment (Review)

International Journal of Molecular Medicine, Год журнала: 2021, Номер 49(2)

Опубликована: Дек. 8, 2021

Stroke is the leading cause of disabilities and cognitive deficits, accounting for 5.2% all mortalities worldwide. Transient or permanent occlusion cerebral vessels leads to ischemic strokes, which constitutes majority strokes. Ischemic strokes induce brain infarcts, along with tissue death focal neuronal damage. The infarct size neurological severity after stroke episodes depends on time period since occurrence, ischemia, systemic blood pressure, vein systems location amongst others. a complex disease, injuries have been focus current studies. present review will provide basic pathological background infarcts. Moreover, major mechanisms underlying are summarized. This also briefly summarize some representative clinical trials up‑to‑date treatments that applied

Язык: Английский

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The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

Cell Proliferation, Год журнала: 2020, Номер 53(3)

Опубликована: Фев. 8, 2020

Abstract Central nervous system (CNS) maintains a high level of metabolism, which leads to the generation large amounts free radicals, and it is also one most vulnerable organs oxidative stress. Emerging evidences have shown that, as key homeostatic cells in CNS, astrocytes are deeply involved multiple aspects CNS function including stress regulation. Besides, redox can turn affect morphology function. The complex roles indicate that their correct performance crucial for normal functioning its dysfunction may result occurrence progression various neurological disorders. To date, influence rarely reviewed. Therefore, this review we sum up regulation corresponding mechanisms under both different pathological conditions.

Язык: Английский

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Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

Journal of Ethnopharmacology, Год журнала: 2022, Номер 289, С. 115021 - 115021

Опубликована: Янв. 26, 2022

Язык: Английский

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Mitochondria as a therapeutic target for ischemic stroke

Free Radical Biology and Medicine, Год журнала: 2019, Номер 146, С. 45 - 58

Опубликована: Ноя. 5, 2019

Язык: Английский

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Oxidative Stress and the Microbiota‐Gut‐Brain Axis

Oxidative Medicine and Cellular Longevity, Год журнала: 2018, Номер 2018(1)

Опубликована: Янв. 1, 2018

The gut‐brain axis is increasingly recognized as an important pathway of communication and physiological regulation, gut microbiota seems to play a significant role in this mutual relationship. Oxidative stress one the most pathogenic mechanisms for both neurodegenerative diseases, such Alzheimer’s or Parkinson’s, acute conditions, stroke traumatic brain injury. A peculiar type might increase inflammation reactive oxygen species levels favor abnormal aggregation proteins. Reversely, lesions various etiologies result alteration properties microbiota. These recent hypotheses could open door new therapeutic approaches neurological diseases.

Язык: Английский

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Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke

Current Neurology and Neuroscience Reports, Год журнала: 2023, Номер 23(8), С. 407 - 431

Опубликована: Июль 3, 2023

Язык: Английский

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The Predictive Role of Systemic Inflammation Response Index (SIRI) in the Prognosis of Stroke Patients

Clinical Interventions in Aging, Год журнала: 2021, Номер Volume 16, С. 1997 - 2007

Опубликована: Дек. 1, 2021

Stroke is a disease associated with high mortality. Many inflammatory indicators such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte to monocyte (LMR) and red blood cell distribution width (RDW) have been documented predict stroke prognosis, their predictive power limited. A novel indicator called systemic response index (SIRI) has advocated an essential role in the prognostic assessment of cancer infectious diseases. In this study, we attempted assess prognosis by SIRI. Moreover, compared SIRI other clinical parameters, including NLR, PLR, LMR RDW. This was retrospective cohort study. We obtained data 2450 patients from Multiparametric Intelligent Monitoring Intensive Care III database. used Cox proportional hazards models evaluate relationship between all-cause mortality sepsis. Receiver operating curve (ROC) analysis RDW for stroke. collected 180 First Affiliated Hospital Wenzhou Medical University, which Pearson's correlation coefficient National Institute Health scale (NIHSS). After adjusting multiple covariates, found that patients. Rising accompanied rising Besides, ROC showed area under significantly greater than test confirmed significant positive NIHSS. Elevated higher risk sepsis severity. Therefore, promising low-grade factor predicting outperformed LMR, power.

Язык: Английский

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Role of Ferroptosis in Stroke

Cellular and Molecular Neurobiology, Год журнала: 2022, Номер 43(1), С. 205 - 222

Опубликована: Янв. 31, 2022

Язык: Английский

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The role of miRNAs in insulin resistance and diabetic macrovascular complications – A review

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 230, С. 123189 - 123189

Опубликована: Янв. 7, 2023

Язык: Английский

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Mitochondrial dysfunctions induce PANoptosis and ferroptosis in cerebral ischemia/reperfusion injury: from pathology to therapeutic potential

Frontiers in Cellular Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Май 24, 2023

Ischemic stroke (IS) accounts for more than 80% of the total stroke, which represents leading cause mortality and disability worldwide. Cerebral ischemia/reperfusion injury (CI/RI) is a cascade pathophysiological events following restoration blood flow reoxygenation, not only directly damages brain tissue, but also enhances series pathological signaling cascades, contributing to inflammation, further aggravate damage tissue. Paradoxically, there are still no effective methods prevent CI/RI, since detailed underlying mechanisms remain vague. Mitochondrial dysfunctions, characterized by mitochondrial oxidative stress, Ca 2+ overload, iron dyshomeostasis, DNA (mtDNA) defects quality control (MQC) disruption, closely relevant process CI/RI. There increasing evidence that dysfunctions play vital roles in regulation programmed cell deaths (PCDs) such as ferroptosis PANoptosis, newly proposed conception unique form innate immune inflammatory death regulated multifaceted PANoptosome complexes. In present review, we highlight how this key event contributes response well modes during Neuroprotective agents targeting may serve promising treatment strategy alleviate serious secondary injuries. A comprehensive insight into dysfunctions-mediated PCDs can help provide strategies guide therapies CI/RI IS.

Язык: Английский

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