Headache, Год журнала: 2023, Номер unknown, С. 61 - 75
Опубликована: Янв. 1, 2023
Язык: Английский
Frontiers in Medicine, Год журнала: 2022, Номер 9
Опубликована: Апрель 12, 2022
The ongoing pandemic Coronavirus Disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a matter of global concern in terms public health Within symptoms secondary to SARS-CoV-2 infection, hyposmia and anosmia have emerged as characteristic during onset pandemic. Although many researchers investigated etiopathogenesis this phenomenon, main cause not clear. appearance new variant Omicron has meant breakthrough chronology pandemic, presenting greater transmissibility less severity, according first reports. We been impressed decrease reported with patients reinfected or who had received vaccination before becoming infected. Based on literature published date, review proposes different hypotheses explain possible lesser affectation smell. On one hand, modifications spike protein could produce changes cell tropism interaction proteins that promote virus uptake (ACE-2, TMPRSS2, TMEM16F). These can be found sustentacular cells glandular olfactory epithelium. Second, due characteristics previous immunity (infection vaccination), there systemic local inflammation would generate damage epithelium and/or central nervous system.
Язык: Английский
Процитировано
37
Journal of Medical Virology, Год журнала: 2022, Номер 94(10), С. 4628 - 4643
Опубликована: Июнь 16, 2022
The global pandemic of COVID-19 began in December 2019 and is still continuing. past 2 years have seen the emergence several variants that were more vicious than each other. Omicron (B.1.1.529) proved to be a huge epidemiological concern as rate infection this particular strain was enormous. identified South Africa on November 24, 2021 classified "Variant Concern" 26, 2021. variant possessed mutations key RBD region, S thereby increasing affinity ACE2 for better transmission virus. Antibody resistance found it able reduce vaccine efficiency vaccines. need booster brought forth due prevalence and, subsequently, led targeted research development variant-specific vaccines dosage. This review discusses broadly genomic characters features along with its specific mutations, evolution, antibody resistance, evasion, utilization CRISPR-Cas12a assay detection, T-cell immunity elicited by against Omicron, strategies decrease also XE recombinant infectivity BA.2 subvariant Omicron.
Язык: Английский
Процитировано
23
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(19), С. 11291 - 11291
Опубликована: Сен. 25, 2022
Long-term neurological and mental complications of COVID-19, the so-called post-COVID syndrome or long COVID, affect quality life. The most persistent manifestations COVID include fatigue, anosmia/hyposmia, insomnia, depression/anxiety, memory/attention deficits. physiological basis psychiatric disorders is still poorly understood. This review summarizes current knowledge sequelae in patients discusses brain demyelination as a possible mechanism these with focus on neuroimaging findings. Numerous reviews, experimental theoretical studies consider one mechanisms central neural system impairment. Several factors might cause demyelination, such inflammation, direct effect virus oligodendrocytes, cerebrovascular disorders, inducing myelin damage. There contradiction between solid fundamental underlying injuries relatively little published clinical evidence related to COVID-19 patients. reason for this probably lies fact that used conventional MRI techniques, which can detect only large, clearly visible demyelinating lesions. A very limited number use specific methods quantification detected changes white matter tracts 3 10 months after acute phase COVID-19. Future research applying quantitative assessment combination psychological will help understanding associated demyelination.
Язык: Английский
Процитировано
20
Cancers, Год журнала: 2023, Номер 15(3), С. 632 - 632
Опубликована: Янв. 19, 2023
Severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) emerged at the end of 2019 and rapidly caused a pandemic that led to death >6 million people due hypercoagulation cytokine storm. In addition, SARS-CoV-2 triggers wide array pathologies, including liver dysfunction neurological disorders. It remains unclear if these events are direct infection respective tissues or result from systemic inflammation. Here, we explored possible hepatic CNS cell lines by SARS-CoV-2. We show even moderate expression levels angiotensin-converting enzyme (ACE2) sufficient for productive infection. infects hepatoma Huh7.5 HepG2 cells but not non-transformed progenitor hepatocyte/cholangiocyte-like HepaRG cells. However, exposure virus causes partial dedifferentiation can also establish efficient replication in some low-passage, high-grade glioblastoma lines. contrast, embryonal primary astrocytes neuroblastoma did support virus. Glioblastoma permissiveness is with defects interferon production. Overall, results suggest during COVID-19 Furthermore, tumors may potentially serve as reservoirs
Язык: Английский
Процитировано
10
Neurological Sciences, Год журнала: 2023, Номер unknown
Опубликована: Фев. 9, 2023
Язык: Английский
Процитировано
9
Cureus, Год журнала: 2025, Номер unknown
Опубликована: Фев. 26, 2025
We report a challenging case of 32-year-old previously healthy pregnant woman at 17+2 weeks gestation with new diagnosis exceptional highly active relapsing-remitting multiple sclerosis (RRMS) triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Remarkable clinical characteristics were the rapid deterioration, severity and nature symptoms, including spastic tetraplegia, dyspnea, dysphagia, anarthria, pain syndrome, which resulted in need for intensive care mechanical ventilation within 24 hours. Relapse treatment, as well symptomatic was complicated pregnancy. Early diagnosis, consistent persistent interdisciplinary management six stay unit 3.5 months neurorehabilitation, led to full recovery patient born child. In addition remarkable characteristics, we therapeutic measures throughout hospitalization. This could, therefore, assist others who may be confronted similar situation.
Язык: Английский
Процитировано
0
Exploration of Medicine, Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Aim: COVID-19, a multisystemic syndrome caused by SARS-CoV-2, often results in long-term complications collectively referred to as long COVID. This study explores the persistence of neurological and otolaryngological symptoms patients two years after acute infection, with focus on gender differences variant-specific effects. Methods: A retrospective follow-up was conducted January 2024 112 who had been hospitalized for COVID-19. Patients completed questionnaire assessing neuropsychiatric, otolaryngological, systemic symptoms. Results: Findings reveal that 18.3% women reported persistent neuropsychiatric symptoms, such memory deficits, depression, concentration issues, compared 5.7% men. Otolaryngological including anosmia ageusia, largely resolved, only 4.5% reporting issues. Symptom more common older individuals, women, smokers, those severe acute-phase illness. Neuropsychiatric remain prominent, underscoring need targeted care. Conclusions: Vaccination significantly reduces risk severity COVID, particularly emphasizing its role mitigating burden SARS-CoV-2. Future research should explore biomolecular markers imaging techniques better understand address these sequelae.
Язык: Английский
Процитировано
0
International Journal of Immunopathology and Pharmacology, Год журнала: 2023, Номер 37, С. 039463202311549 - 039463202311549
Опубликована: Янв. 30, 2023
Encephalitis lethargica developed in epidemic from 1919 to 1926 Europe and throughout the world. From clinical point of view, disturbances consciousness alertness possible outcomes a postencephalitic Parkinsonism has attracted much attention. For long time, it was thought that such disease may still occur sporadically. In this review, authors examined historical current pictures epidemics be related lethargica. The previous Nona Russian Influenza exhibited frequent neurological symptoms. Spanish flu, formerly lethargica, would appear an had its development partially overlapping period. pandemic linked COVID-19 sometimes aspects can resemble Based on analysis more recent immunological data, could suggested autoimmune encephalitis arose secondary form action viral agent. It cannot ruled out agent coronavirus. nosological term should abolished designating run
Язык: Английский
Процитировано
8
ZRC SAZU, Založba ZRC eBooks, Год журнала: 2022, Номер unknown
Опубликована: Дек. 20, 2022
JAVNOZDRAVSTVENI IZZIVI DEMENCE
Процитировано
11
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(12), С. 6669 - 6669
Опубликована: Июнь 18, 2024
SARS-CoV-2 is the causative agent of COVID-19 pandemic, acute respiratory disease which, so far, has led to over 7 million deaths. There are several symptoms associated with infections which include neurological and psychiatric disorders, at least in case pre-Omicron variants. infection can also promote onset glioblastoma patients without prior malignancies. In this study, we focused on Envelope protein codified by virus genome, acts as viroporin that reported be central for propagation. particular, characterized electrophysiological profile E-protein transfected U251 HEK293 cells through patch-clamp technique FURA-2 measurements. Specifically, observed an increase voltage-dependent (Kv) calcium-dependent (KCa) potassium currents cell lines, respectively. Interestingly, both cellular models, a depolarization mitochondrial membrane potential accordance alteration growth. We, therefore, investigated transcriptional effect E signaling pathways found gene alterations apoptosis, cytokines WNT pathways. The changes after expression could explain impact gliomagenesis.
Язык: Английский
Процитировано
2