bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 25, 2024
Abstract
Neurotrophins
play
pivotal
roles
in
the
development
and
proper
functioning
of
nervous
system.
The
effects
these
growth
factors
are
mediated
through
binding
high-affinity
receptors,
known
as
Trks,
well
low-affinity
receptor
p75NTR.
latter
has
capacity
to
induce
complex
signal
pathways,
it
favors
both
pro-survival
pro-apoptotic
cascades
depending
on
physiopathological
condition.
Recent
findings
have
indicated
that
p75NTR
expression
is
increased
post-mortem
Parkinson’s
disease
(PD)
brains,
this
upregulation
associated
with
a
significant
reduction
neuroprotection.
Given
its
double-edged
sword
nature,
recently
been
identified
promising
therapeutic
target
counteract
neurodegenerative
events.
present
study
aims
assess
neuroprotective
modulation
rotenone-induced
neuronal
model
PD.
To
end,
differentiated
SH-SY5Y
cells
were
exposed
rotenone
mimic
PD
phenotype,
small
molecule
LM11A-31
was
used
modulate
activity.
main
results
revealed
significantly
mitigated
hallmarks
PD,
including
cell
death,
neuromorphological
aberrations,
α-synuclein
accumulation.
Pharmacological
manipulation
also
reduced
oxidative
damage
by
increasing
transcriptional
regulate
antioxidant
response
decreasing
pro-oxidant
NADPH-oxidase
modulatory
subunits.
Furthermore,
hampered
cholesterol
buildup
induced
rotenone,
normalizing
proteins
involved
biosynthesis,
uptake
intracellular
trafficking.
Taken
together,
suggest
may
represent
novel
approach
counteracting
abnormalities
redox
metabolism.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(3), С. 1689 - 1689
Опубликована: Янв. 30, 2024
Neurodegenerative
diseases
are
an
increasingly
common
group
of
that
occur
late
in
life
with
a
significant
impact
on
personal,
family,
and
economic
life.
Among
these,
Alzheimer’s
disease
(AD)
Parkinson’s
(PD)
the
major
disorders
lead
to
mild
severe
cognitive
physical
impairment
dementia.
Interestingly,
those
may
show
onset
prodromal
symptoms
early
after
middle
age.
Commonly,
evaluation
these
neurodegenerative
is
based
detection
biomarkers,
where
functional
structural
magnetic
resonance
imaging
(MRI)
have
shown
central
role
revealing
or
phases,
although
it
can
be
expensive,
time-consuming,
not
always
available.
The
aforementioned
visual
system
due
pathophysiological
mechanisms
shared
between
eye
brain.
In
disease,
α-synuclein
deposition
retinal
cells,
as
well
dopaminergic
neurons
substantia
nigra,
alters
cortex
function,
resulting
modifications
field.
Similarly,
modified
by
neurofibrillary
tangles
neuritic
amyloid
β
plaques
typically
seen
brain,
this
reflect
accumulation
biomarkers
retina
during
stages
postmortem
retinas
AD
patients.
light,
ophthalmic
neurodegeneration
could
become
cost-effective
method
for
diagnosis
diseases,
overcoming
limitations
deep
This
analysis
commonly
used
practice,
interest
has
risen
recent
years.
review
will
discuss
relationship
degeneration,
highlighting
how
represent
noninvasive
straightforward
diseases.
Diabetes Obesity and Metabolism,
Год журнала:
2024,
Номер
26(8), С. 3031 - 3044
Опубликована: Май 27, 2024
Abstract
Depression
is
a
mood
disorder
that
may
increase
risk
for
the
development
of
insulin
resistance
(IR)
and
type
2
diabetes
(T2D),
vice
versa.
However,
mechanistic
pathway
linking
depression
T2D
not
fully
elucidated.
The
aim
this
narrative
review,
therefore,
was
to
discuss
possible
link
between
T2D.
coexistence
twice
as
great
compared
occurrence
either
condition
independently.
Hyperglycaemia
dyslipidaemia
promote
incidence
by
enhancing
inflammation
reducing
brain
serotonin
(5‐hydroxytryptamine
[5HT]).
Dysregulation
signalling
in
impairs
5HT
signalling,
leading
depression.
Furthermore,
associated
with
hyperglycaemia
poor
glycaemic
control.
Psychological
stress
In
conclusion,
could
be
potential
factor
through
induction
inflammatory
reactions
oxidative
affect
neurotransmission.
addition,
chronic
induce
dysregulation
hypothalamic–pituitary–adrenal
axis
circulating
cortisol
levels,
which
triggers
IR
One
of
the
key
hallmarks
Parkinson's
disease
is
disruption
lipid
homeostasis
in
brain,
which
plays
a
critical
role
neuronal
membrane
integrity
and
function.
Understanding
how
treadmill
training
impacts
restructuring
its
subsequent
influence
on
motor
function
could
provide
basis
for
developing
targeted
non-pharmacological
interventions
individuals
living
with
early
stage
PD.
This
study
aims
to
investigate
effects
intervention
deficits
induced
by
6-OHDA
rats
model
PD
was
injecting
6-hydroxy
dopamine
(6-OHDA)
into
medial
forebrain
bundle
(MFB).
For
10
weeks,
underwent
four-lane
motorized
treadmill.
Motor
were
evaluated
through
behavioral
tests.
Lipidomic
analysis
performed
ultrahigh-performance
liquid
chromatography-tandem
mass
spectrometry
(UPLC
MS/MS).
Treadmill
significantly
improved
restored
altered
brain
muscle
profiles
rats.
Among
species
identified
rats,
abundance
highest
phosphatidylethanolamine
(PE),
correlating
positively
beam-walking
scores;
peaked
lysophosphatidylethanolamine
(LysoPE),
grip
strength
scores.
In
levels
diacylglycerol
(DG),
triacylglycerol
(TG),
lysophosphatidylcholine
(PC)
correlated
rotarod
scores,
while
only
(PE)
linked
muscle,
phosphatidylinositol
(PI),
lysophosphatidic
acid
(PA),
ceramide
(Cer),
ganglioside
conclusion,
may
protect
cortex,
mitigating
via
change
muscle.
