Serum NGF and BDNF in Long-COVID-19 Adolescents: A Pilot Study

Diagnostics, Год журнала: 2022, Номер 12(5), С. 1162 - 1162

Опубликована: Май 7, 2022

COVID-19 (COronaVIrus Disease 19) is an infectious disease also known as acute respiratory syndrome caused by the SARS-CoV-2. Although in children and adolescents SARS-CoV-2 infection produces mostly mild or moderate symptoms, a certain percentage of recovered young people condition malaise, defined long-COVID-19, remains. To date, risk factors for development long-COVID-19 are not completely elucidated. Neurotrophins such NGF (Nerve Growth Factor) BDNF (Brain-Derived Neurotrophic to regulate only neuronal growth, survival plasticity, but influence cardiovascular, immune, endocrine systems physiological and/or pathological conditions; date few papers have discussed their potential role COVID-19. In present pilot study, we aimed identify changes serum small cohort male female that contracted during second wave pandemic (between September October 2020), notably absence available vaccines. Blood withdrawal was carried out when recruited tested negative (“post-infected COVID-19”), 30 35 days after last molecular test. According related outcomes, individuals were divided into three groups: asymptomatics, symptomatics over time developed symptoms (“future long-COVID-19”). As control group, analyzed age-matched healthy controls did contract infection. Inflammatory biomarkers (TNF-α, TGF-β), MCP-1, IL-1α, IL-2, IL-6, IL-10, IL-12) with free oxygen radicals’ presence oxidative stress index. We showed content lower post-infected-COVID-19 compared controls; levels found be higher symptomatic future girls, leaving unchanged asymptomatic if controls. Oxidative inflammatory adolescents, except TGF-β that, similarly BDNF, girls. predicted could used early morbidity adolescents.

Язык: Английский

---

SARS-CoV-2 post-acute sequelae in previously hospitalised patients: systematic literature review and meta-analysis

European Respiratory Review, Год журнала: 2023, Номер 32(169), С. 220254 - 220254

Опубликована: Июль 12, 2023

Background Many individuals hospitalised with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection experience post-acute sequelae of SARS-CoV-2 (PASC), sometimes referred to as “long COVID”. Our objective was conduct a systematic literature review and meta-analysis identify PASC-associated symptoms in previously patients determine the frequency temporal nature PASC. Methods Searches MEDLINE, Embase, Cochrane Library (2019–2021), World Health Organization International Clinical Trials Registry Platform reference lists were performed from November December 2021. Articles assessed by two reviewers against eligibility criteria risk bias tool. Symptom data synthesised random effects meta-analyses. Results Of 6942 records, 52 studies at least 100 analysed; ∼70% Europe-based studies. Most first wave pandemic. PASC analysed 28 days after hospital discharge. At 1–4 months infection, most frequent individual fatigue (29.3% (95% CI 20.1–40.6%)) dyspnoea (19.6% 12.8–28.7%)). experienced one symptom 4–8 (73.1% 44.2–90.3%)) 8–12 (75.0% 56.4–87.4%)). Conclusions A wide spectrum persistent reported over 1-year follow-up period significant proportion participants. Further research is needed better define duration whether factors such disease severity, vaccination treatments have an impact on

Язык: Английский

---

Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis

European Respiratory Review, Год журнала: 2023, Номер 32(169), С. 220253 - 220253

Опубликована: Авг. 9, 2023

Background A proportion of coronavirus disease 2019 (COVID-19) survivors experience persistent dyspnoea without measurable impairments in lung function. We performed a systematic review and meta-analysis to determine relationships between imaging abnormalities over time post-COVID-19 patients. Methods Using the Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) guidelines, we analysed studies published prior 15 September 2022 indexed by Google Scholar, PubMed LitCOVID which assessed chest adults ≥3 months after COVID-19. Demographic, imaging, spirometric symptom data were extracted. The dyspnoea, sex age determined using random effects model meta-regression. Results 47 included (n=3557). most prevalent computed tomography (CT) abnormality was ground-glass opacities (GGOs) (44.9% (95% CI 37.0–52.9%) at any follow-up time-point). Occurrence reticulations significantly decreased early late (p=0.01). prevalence related patients with (p=0.012). females negatively correlated presence (p=0.001), bronchiectasis (p=0.001) consolidations (p=0.025). Age positively across all modalities (p=0.002) present only on CT (GGOs (p=0.004) (p=0.001)). Spirometric values improved during but remained within normal range time-points. Conclusions Imaging common 3 COVID-19 their occurrence dyspnoea. This suggests that is sensitive tool detecting pulmonary even measurements.

Язык: Английский

---

How do German General Practitioners Manage Long-/Post-COVID? A Qualitative Study in Primary Care

Viruses, Год журнала: 2023, Номер 15(4), С. 1016 - 1016

Опубликована: Апрель 20, 2023

Background: Many patients with ongoing complaints after a SARS-CoV-2 infection are treated in primary care. Existing medical guidelines on how to diagnose and treat Long-/Post-COVID far from being comprehensive. This study aims describe German general practitioners (GPs) deal this situation, what problems they experience when managing such patients, solve associated the diagnosis treatment of Long-/Post-COVID. Methods Findings: We conducted qualitative interviewed 11 GPs. The most commonly described symptoms were fatigue, dyspnea, chest tightness decrease physical capacity. common way identify was by exclusion. Patients suffering generally their GPs rarely referred. A very non-pharmacological intervention take wait-and-see approach grant sick leave. Other interventions included lifestyle advices, exercise, acupuncture exercises intense aromas. Pharmacological treatments focused symptoms, like respiratory or headaches. Our study’s main limitations small sample size therefore limited generalizability results. Conclusions: Further research is required develop test pharmaceutical non-pharmaceutical for In addition, strategies prevent occurrence an acute have be developed. routine collection data management may help formulation best practices. It up policymakers facilitate necessary implementation effective order limit huge societal consequences large groups

Язык: Английский

---

Musculoskeletal complications in long COVID-19: A systematic review

World Journal of Virology, Год журнала: 2022, Номер 11(6), С. 485 - 495

Опубликована: Ноя. 23, 2022

Coronavirus disease 2019 (COVID-19) has crippled humanity since early 2020. Various sequelae of COVID-19 have been reported in different body systems. Musculoskeletal symptoms are widely during infection, but musculoskeletal complications long underreported. However, post-COVID-19 survivors complaints persisting or new-onset fatigue, myalgia, arthralgia, arthritis, muscle weakness, etc clinical practice. The well-known detrimental effects steroids on the system coupled with their over-the-counter availability can also be anticipated they were cornerstone life-saving management this pandemic.To determine COVID.We performed a systematic review 'systematic reviews and meta-analyses'.Of 63 articles screened, 24 included. Two specifically discussed children adolescents. One article rehabilitation intervention. No addressed issues particular. Fatigue was most common complication.Fatigue is found to very along myalgia arthralgia. There no studies intervention specifically. Considering lacuna literature needs current situation, further warranted standardize effective interventions complications. More homogenous needed. Studies functional impairment due involvement essential.

Язык: Английский

---

Association of preexisting psychiatric disorders with post-COVID-19 prevalence: a cross-sectional study

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Янв. 7, 2023

Abstract Evidence demonstrating the association of preexisting psychiatric disorders with post-COVID-19 is limited. We aim to investigate using larger sample sizes and more extended postinfection periods than previous studies. A total 6015 (response rate = 77.5%) COVID-19 survivors were surveyed a self-administered questionnaire from July September 2021. Poisson regression analysis robust error variance was performed estimate prevalence ratios (PRs) or without disorders. Participants numbered 1067 (17.7%), 2149 (35.7%). Post-COVID-19 PR 1.09 (95% CI 1.02–1.18, p 0.013). The interaction between significant (p for < 0.001). subgroup showed that those might be at greater prolonged risk These findings suggested associated an increased risk, prolong even if time passes.

Язык: Английский

---

Rehabilitative interventions in patients with persistent post COVID-19 symptoms—a review of recent advances and future perspectives

European Archives of Psychiatry and Clinical Neuroscience, Год журнала: 2023, Номер 274(8), С. 1819 - 1828

Опубликована: Июнь 16, 2023

The SARS-CoV-2 pandemic has not only caused millions of deaths but left also people with persistent symptoms behind. These long-term COVID-19 sequelae cause a considerable burden on individuals´ health, healthcare systems, and economies worldwide given the high rate infections. Therefore, rehabilitative interventions strategies are needed to counteract post sequelae. importance rehabilitation for patients been recently highlighted in Call Action by World Health Organisation. Based previously published research, line clinical experience, is one specific disease rather presents different phenotypes that vary their pathophysiological mechanisms, symptomatic manifestations, potential interventional approaches. This review provides proposal differentiating non-organ-specific may help clinicians evaluate plan therapeutic options. Furthermore, we present current unmet needs suggest pathway approach post-COVID symptoms.

Язык: Английский

---

Precision management of post‐COVID pain: An evidence and clinical‐based approach

European Journal of Pain, Год журнала: 2023, Номер 27(9), С. 1107 - 1125

Опубликована: Фев. 28, 2023

Abstract Background Pain after a SARS‐CoV‐2 acute infection (post‐COVID pain) is becoming new healthcare emergency but remains underestimated and most likely undertreated due to lack of recognition the phenomenon knowledge underlying pain mechanisms. Evidence supporting any particular treatment approach for management post‐COVID lacking. Large variability in patient response standard treatments clinically observed, which has led calls personalized, tailored treating patients with chronic (i.e. ‘precision medicine’). Applying global concerted action towards precision medicine could help guide clinical decision‐making aid more effective treatments. Methods The current position paper discusses factors be considered by clinicians managing ranging from identification phenotype genetic consideration. Results ability into nociceptive, neuropathic, nociplastic or mixed type suggested as first step better planification programme. Further, consideration other factors, such gender, comorbidities, received at phase onset‐associated COVID‐19 symptoms, during hospitalization presence emotional disturbances should implemented Conclusions Accordingly, considering these include multimodal pharmacological non‐pharmacological modalities targeting emotional/cognitive aspects psychological and/or coping strategies), central sensitization‐associated mechanisms neuroscience education), exercise programmes well lifestyle interventions (e.g. nutritional support sleep management). Significance This presents an evidence‐based reasoning pain.

Язык: Английский

---

Determinants of post-COVID-19 symptoms among adults aged 55 or above with chronic conditions in primary care: data from a prospective cohort in Hong Kong

Frontiers in Public Health, Год журнала: 2023, Номер 11

Опубликована: Май 5, 2023

Primary care patients, especially those with an older age, are one of the most vulnerable populations for post-COVID-19 symptoms. Identifying predictors post-COVID symptoms can help identify high-risk individuals preventive care.Out 977 primary patients aged 55 years or above comorbid physical and psychosocial conditions in a prospective cohort Hong Kong, 207 infected previous 5-24 weeks were included. The three common (breathlessness, fatigue, cognitive difficulty), which lasted beyond 4-week acute infection period, assessed using items from COVID-19 Yorkshire Rehabilitation Scale (C19-YRS), together other self-reported Multivariable analyses conducted to post-acute long (5-24 after infection).The participants had mean age 70.8 ± 5.7 years, 76.3% female, 78.7% ≥2 chronic conditions. In total, 81.2% reported at least symptom (mean: 1.9 1.3); 60.9, 56.5 30.0% difficulty, breathlessness respectively; 46.1% new (such as respiratory-related (14.0%), insomnia poor sleep quality ear/nose/throat (e.g., sore throat) (10.1%), etc.). Depression predicted fatigue. female sex difficulty. Receiving fewer vaccine doses (2 vs. 3 doses) was associated breathlessness. Anxiety higher overall severity level symptoms.Depression, sex, Promoting vaccination providing intervention warranted.

Язык: Английский

---

Covid-19 and Parkinson's disease: Acute clinical implications, long-COVID and post-COVID-19 parkinsonism

International review of neurobiology, Год журнала: 2022, Номер unknown, С. 63 - 89

Опубликована: Янв. 1, 2022

Язык: Английский

---