Circulating Non-Coding RNAs as Indicators of Fibrosis and Heart Failure Severity DOI Creative Commons

Veronika Boichenko,

Victoria Maria Noakes,

Benedict Reilly-O’Donnell

и другие.

Cells, Год журнала: 2025, Номер 14(7), С. 553 - 553

Опубликована: Апрель 7, 2025

Heart failure (HF) is a leading cause of morbidity and mortality worldwide, representing complex clinical syndrome in which the heart’s ability to pump blood efficiently impaired. HF can be subclassified into heart with reduced ejection fraction (HFrEF) preserved (HFpEF), each distinct pathophysiological mechanisms varying levels severity. The progression significantly driven by cardiac fibrosis, pathological process extracellular matrix undergoes abnormal uncontrolled remodelling. Cardiac fibrosis characterized excessive protein deposition activation myofibroblasts, increasing stiffness heart, thus disrupting its normal structure function promoting lethal arrythmia. MicroRNAs, long non-coding RNAs, circular collectively known as RNAs (ncRNAs), have recently gained significant attention due growing body evidence suggesting their involvement remodelling such fibrosis. ncRNAs found peripheral blood, indicating potential biomarkers for assessing In this review, we critically examine recent advancements findings related use discuss implication development.

Язык: Английский

Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases DOI Creative Commons

Yi He,

Yuwei Cai, Yanyan Cao

и другие.

Biomedicines, Год журнала: 2025, Номер 13(1), С. 117 - 117

Опубликована: Янв. 7, 2025

Cardiovascular diseases (CVDs) are a leading cause of death worldwide, and new therapeutic strategies urgently needed. In recent years, enhancer RNAs (eRNAs) have gradually attracted attention because they offer directions for the treatment CVDs. Super-enhancer (seRNAs) subset non-coding that transcribed from regions genome known as super enhancers, which large clusters enhancers with high density transcription factors cofactors. These play pivotal role in regulating genes involved cell identity disease progression. This article reviews characteristics seRNAs, their expression patterns, regulatory mechanisms cardiovascular system. We also explore occurrence development CVDs, well potential diagnostic biomarkers targets. Currently, therapies targeting seRNAs research hotspot. The specific inhibitors or activators is expected to facilitate precise interventions addition, use gene editing techniques modify relevant eRNA introduces possibilities treatment. review aims provide comprehensive overview CVDs discusses novel class

Язык: Английский

Процитировано

0
The Role of Non-coding RNAs in Diabetic Retinopathy: Mechanistic Insights and Therapeutic Potential DOI

Zhuan Zuo,

Ni Li, Qian Zhang

и другие.

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Circulating Non-Coding RNAs as Indicators of Fibrosis and Heart Failure Severity DOI Creative Commons

Veronika Boichenko,

Victoria Maria Noakes,

Benedict Reilly-O’Donnell

и другие.

Cells, Год журнала: 2025, Номер 14(7), С. 553 - 553

Опубликована: Апрель 7, 2025

Heart failure (HF) is a leading cause of morbidity and mortality worldwide, representing complex clinical syndrome in which the heart’s ability to pump blood efficiently impaired. HF can be subclassified into heart with reduced ejection fraction (HFrEF) preserved (HFpEF), each distinct pathophysiological mechanisms varying levels severity. The progression significantly driven by cardiac fibrosis, pathological process extracellular matrix undergoes abnormal uncontrolled remodelling. Cardiac fibrosis characterized excessive protein deposition activation myofibroblasts, increasing stiffness heart, thus disrupting its normal structure function promoting lethal arrythmia. MicroRNAs, long non-coding RNAs, circular collectively known as RNAs (ncRNAs), have recently gained significant attention due growing body evidence suggesting their involvement remodelling such fibrosis. ncRNAs found peripheral blood, indicating potential biomarkers for assessing In this review, we critically examine recent advancements findings related use discuss implication development.

Язык: Английский

Процитировано

0