Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
Язык: Английский
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
Язык: Английский
Asian Journal of Pharmaceutical Sciences, Год журнала: 2025, Номер unknown, С. 101058 - 101058
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0Journal of Biochemical and Molecular Toxicology, Год журнала: 2024, Номер 38(11)
Опубликована: Ноя. 1, 2024
Natural killer (NK) cells are vital innate immune that play a crucial role in cancer therapy. They targeted by therapies designed to modulate, retain, and enhance their antitumor function vivo. In addition whole-cell therapy, NK cell-derived exosomes (NDEs) offer high safety easily subject chemical, biological, immunological modifications. This makes them suitable for use combination with various current efficacy, treatment outcomes, reduce side effects review aims outline summarizes the potential of cells, as well challenges opportunities cell-based immunotherapies such allogeneic autologous cell transplantation, CAR cytokines monoclonal antibodies. The also explores dual regulatory tumor on highlights NDEs, either alone or other therapies, reprogram immunosuppressive microenvironment expedite therapeutic immunotherapy future clinical research.
Язык: Английский
Процитировано
2Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 7, 2024
Background Cell death plays an essential role in carcinogenesis, but its function the recurrence and postoperative prognosis of head neck cancer (HNC), which ranks as 7 th most common malignancy globally, remains unclear. Methods Data from five main subtypes HNC related single-cell RNA sequencing (scRNA-seq) were recruited to establish a atlas, distribution cell models (CDMs) across different tissues well analyzed. Bulk RNA-seq Cancer Genome Atlas Program (TCGA) dataset was subjected machine learning-based integrative procedure for constructing consensus death-related signature risk score (CDRscore) model validated by external data. The biofunctions including expression analysis, immune infiltration, genomic mutations, enrichment analysis cellchat compared between high- low- groups categorized this CDRscore model. Finally, samples laryngeal squamous (LSCC) conducted spatial transcriptomics (ST) further validate results Results T cells patients manifested highest levels while HPV infection attenuates malignant based on atlas. CDMs are positively correlated with tumor-cell stemness, immune-related infiltrated. A established transcription ten prognostic genes ( MRPL10 , DDX19A NDFIP1 PCMT1 HPRT1 SLC2A3 EFNB2 HK1 BTG3 MAP2K7 ). It functions independent factor overall survival displays stable powerful performance GSE41613 GSE65858 datasets. Patients high worse survival, more active epithelial mesenchymal transition, TGF-β-related pathways hypoxia, higher exhausted markers, stronger TP53 mutation. ST LSCC showed that spots high-risk scores colocalized TGF-β proliferating cells, additionally, have negative correlation TCR signaling positive association LAG3 transcription. Conclusion could be utilized indicator HNC.
Язык: Английский
Процитировано
1Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Сен. 23, 2024
Язык: Английский
Процитировано
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