The effects of a modified Mediterranean diet on gut microbiota and clinical outcomes in patients with metastatic colorectal cancer undergoing first-line chemotherapy with either anti-EGFR or anti-VEGF agent: protocol for a randomized pilot study (Preprint)

Опубликована: Фев. 21, 2025

the gut microbiota is attracting increasing interest as an initiator of colorectal cancer. It has been observed that microbial imbalance in and cancer tissue facilitated by a Western type diet, rich meat, sugars, refined grains, while Mediterranean low saturated fat fibers, promotes eubiosis, results reduced risk developing to analyze compare patients with metastatic undergoing first-line chemotherapy +/- biological agent (anti-EGFR or anti-VEGF), receiving either free standard modified diet. this pilot non-drug, interventional prospective, randomized, controlled, single-center, open-label trial. Patients (n=40) will be randomized 1:1 diet Blood fecal samples collected at baseline control visits, for metagenomic metabolomic analysis. The primary endpoint Firmicutes/Bacteroidetes ratio after completion third cycle (time T1). Secondary endpoints are: a) percentage experiencing gastrointestinal side effects T1; b) grade 3/4 c) changes ratio, overall microbiome composition, metabolome T1, sixth (T2) versus baseline. trial received ethics approval on July 24th 2024. By January 2025, 7 participants have recruited. study conclude visit T2 last enrolled patient. Results are expected published October 2028. potential provide critical insights into role modifying microbiota, diminishing chemotherapy-related effects, possibly enhancing therapeutic efficacy Additionally, data may pave way future research immunotherapy, potentially influencing both clinical practice public health strategies. Clinicaltrial.gov NCT06794931 (https://clinicaltrials.gov/search?term=NCT06794931)

Язык: Английский

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Gut microbiota and metabolome signatures in obese and normal-weight patients with colorectal tumors.

iScience, Год журнала: 2025, Номер 28(4), С. 112221 - 112221

Опубликована: Март 14, 2025

Язык: Английский

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The burden of colorectal cancer attributable to diet low in whole grains from 1990 to 2021: a global, regional and national analysis

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Апрель 9, 2025

Colorectal cancer (CRC) is a major global health issue, with rising incidence and mortality rates. Dietary factors, especially whole grains consumption, are critical in determining CRC risk. Understanding deaths disability-adjusted life years (DALYs) related to low diets important for prevention. The purpose of the study investigate temporal geographic trends DALYs attributable diet at global, regional, national levels from 1990 2021. data on burden 2021 were extracted Global Burden Diseases (GBD) database. We described across various years, genders, age groups (5-year 25 94 95+ years), different Socio-demographic Index (SDI) regions countries. To illustrate CRC, we calculated estimated annual percentage change (EAPC) From 2021, number increased 101,813 (95% UI: 42,588 151,170) 186,257 76,127 284,803), representing 82.94% growth. Similarly, 2,540,867 1,050,794 3,754,416) 4,327,219 1,754,865 6,578,232), 70.30% However, both age-standardized rate (ASMR) DALY (ASDR) exhibited decline, an EAPC -0.82 CI: -0.85 -0.78) - 0.84 -0.87 -0.81), respectively. disease heavier high SDI high-middle regions. between only region where ASMR ASDR was low-middle SDI, while all other regions, they showed declining trend. In East Asia had highest regional level, followed by Western Europe High-income North America. Additionally, greater among males elderly. Between rose 102.13% 63.20% females. Generally, age-specific tend increase age. demonstrates nonlinear "S"-shaped correlation grains. negatively associated (R = -0.402, p < 0.001), reaching approximately 0.51 lowest 0.85. similar pattern. Despite decline globally, absolute cases continues increase, particularly notable observed High-middle High as well elderly population. It imperative intensify efforts prevention education, specifically targeting these high-risk raise public awareness consumption Furthermore, screening initiatives should be intensified demographics address elevated risk due insufficient consumption.

Язык: Английский

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Study of Microbiota Associated to Early Tumors Can Shed Light on Colon Carcinogenesis

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13308 - 13308

Опубликована: Дек. 11, 2024

An increasingly important role for gut microbiota in the initiation and progression of colorectal cancer (CRC) has been described. Even early stages transformation, i.e., adenomas, changes composition have observed, several bacterial species, such as pks+ Escherichia coli enterotoxigenic Bacteroides fragilis, proposed to drive colon tumorigenesis. In recent years, strategies developed study mucosa-associated (MAM), which is more closely associated with CRC development than lumen-associated (LAM) derived from fecal samples. This review summarizes state art about oncogenic actions bacteria compares different sampling collect intestinal (feces, biopsies, swabs, brushes, washing aspirates). particular, this article recapitulates current knowledge on MAM adenomas serrated polyps, since studying early-stage tumors can elucidate molecular mechanisms underpinning carcinogenesis.

Язык: Английский

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Pimpinellin Mitigates DSS-Induced Ulcerative Colitis in Mice by Reducing Inflammation and Regulating Gut Microbiota

Phytomedicine, Год журнала: 2024, Номер 136, С. 156308 - 156308

Опубликована: Дек. 6, 2024

Язык: Английский

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