Key toxic components and sources affecting oxidative potential of atmospheric particulate matter using interpretable machine learning: Insights from fog episodes

Journal of Hazardous Materials, Год журнала: 2023, Номер 465, С. 133175 - 133175

Опубликована: Дек. 7, 2023

Язык: Английский

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Origin, Structural Characteristics, and Health Effects of Atmospheric Soot Particles: A Review

Current Pollution Reports, Год журнала: 2024, Номер 10(3), С. 532 - 547

Опубликована: Апрель 24, 2024

Язык: Английский

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Phosphocholine-induced energy source shift alleviates mitochondrial dysfunction in lung cells caused by geospecific PM _2.5 components

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(14)

Опубликована: Март 26, 2024

Fine particulate matter (PM 2.5 ) is globally recognized for its adverse implications on human health. Yet, remain limited the individual contribution of particular PM components to toxicity, especially considering regional disparities. Moreover, prevention solutions -associated health effects are scarce. In present study, we comprehensively characterized and compared primary constituents their altered metabolites from two locations: Taiyuan Guangzhou. Analysis year-long samples revealed 84 major components, encompassing organic carbon, elemental ions, metals, chemicals. exhibited higher contamination, associated risks, dithiothreitol activity, cytotoxicities than Guangzhou’s counterpart. Applying metabolomics, BEAS-2B lung cells exposed both cities were screened significant alterations. A correlation analysis by critical toxic in regions. Among -down-regulated metabolites, phosphocholine emerged as a promising intervention cytotoxicities. Its supplementation effectively attenuated -induced energy metabolism disorder cell death via activating fatty acid oxidation inhibiting Phospho1 expression. The highlighted chemicals displayed combined toxicities, potentially counteracted phosphocholine. Our study offered functional metabolite alleviate cellular provided insights into geo-based variability components.

Язык: Английский

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Estimation of public exposure to PAH and environmental risks via wastewater-based epidemiology

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 292, С. 117920 - 117920

Опубликована: Фев. 22, 2025

Язык: Английский

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Pollution characteristics and health risks of size-resolved particulate-bound polycyclic aromatic compounds in Zhengzhou

Atmospheric Environment, Год журнала: 2025, Номер unknown, С. 121099 - 121099

Опубликована: Фев. 1, 2025

Язык: Английский

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