Brodifacoum causes coagulopathy, hemorrhages, and mortality in rainbow trout (Oncorhynchus mykiss) at environmentally relevant hepatic residue concentrations DOI Creative Commons
Hannah Schmieg,

Hermann Ferling,

Karina Annika Bucher

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 289, С. 117629 - 117629

Опубликована: Янв. 1, 2025

Widely used second-generation anticoagulant rodenticides like brodifacoum are classified as persistent, bioaccumulative, and toxic. Widespread exposure of terrestrial avian non-target species is well-known recently hepatic rodenticide residues have been detected in wild fish. However, no sufficient data exist to interpret the effects these findings on fish health. In order assess potential impact fish, we exposed rainbow trout (Oncorhynchus mykiss) brodifacoum-spiked feed. a first experiment, individually kept (body weight ca. 200 g) were single dose observed for 15 days. second 330 groups fed every 7 or 8 days with feed up 60 Sampling over period allowed monitoring concentrations serum, liver, muscle tissue, well occurring course experiment. both experiments, doses ≥ 75 µg/kg body caused prolonged non-measurable blood coagulation times. Disturbed hemostasis led hemorrhages anemia significantly decreased albumin levels. days-experiment, 100 additionally discoloration, apathy, anorexia, resulting reduced gain, ultimately mortality. The delay until onset overt symptoms (14-17 days) highlights importance test duration while investigating lowest concentration associated was average 122.6 ng/g liver wet weight, which range previously reported These illustrate risks use freshwater reinforce need stipulate all available appropriate risk mitigation measures prevent emissions at source.

Язык: Английский

Brodifacoum causes coagulopathy, hemorrhages, and mortality in rainbow trout (Oncorhynchus mykiss) at environmentally relevant hepatic residue concentrations DOI Creative Commons
Hannah Schmieg,

Hermann Ferling,

Karina Annika Bucher

и другие.

Ecotoxicology and Environmental Safety, Год журнала: 2025, Номер 289, С. 117629 - 117629

Опубликована: Янв. 1, 2025

Widely used second-generation anticoagulant rodenticides like brodifacoum are classified as persistent, bioaccumulative, and toxic. Widespread exposure of terrestrial avian non-target species is well-known recently hepatic rodenticide residues have been detected in wild fish. However, no sufficient data exist to interpret the effects these findings on fish health. In order assess potential impact fish, we exposed rainbow trout (Oncorhynchus mykiss) brodifacoum-spiked feed. a first experiment, individually kept (body weight ca. 200 g) were single dose observed for 15 days. second 330 groups fed every 7 or 8 days with feed up 60 Sampling over period allowed monitoring concentrations serum, liver, muscle tissue, well occurring course experiment. both experiments, doses ≥ 75 µg/kg body caused prolonged non-measurable blood coagulation times. Disturbed hemostasis led hemorrhages anemia significantly decreased albumin levels. days-experiment, 100 additionally discoloration, apathy, anorexia, resulting reduced gain, ultimately mortality. The delay until onset overt symptoms (14-17 days) highlights importance test duration while investigating lowest concentration associated was average 122.6 ng/g liver wet weight, which range previously reported These illustrate risks use freshwater reinforce need stipulate all available appropriate risk mitigation measures prevent emissions at source.

Язык: Английский

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