bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 14, 2024

Abstract Age-related auditory decline manifests across the animal kingdom, from humans and mice to zebrafish insects. Sex differences in are established for humans, but there is now evidence even zebrafish. Here, we found sex an insect, Desert Locust investigated its biological basis. We profiled gene expression a dedicated organ, Müller’s organ understand genetic underpinning of measured sound-evoked transduction currents electrophysiological properties neurons quantify decline. analysed young locusts where were absent older, noise-exposed maximal. The largest between sexes was stressed (aged noise-exposed) organs. sex-specific genes ontology terms juvenile hormone (JH) estrogen-related steroids. hypothesise that due hormones which then affect metabolic processes mitochondria. Highlights Female Locusts have less than males. Female’s organs maintain better metabolism under conditions. maximal during aging noise-exposure. minimal

Язык: Английский