A 3D printed biomimetic scaffold for cartilage regeneration with lubrication, load-bearing, and adhesive fixation properties
Tribology International,
Год журнала:
2024,
Номер
192, С. 109328 - 109328
Опубликована: Янв. 24, 2024
Язык: Английский
Beyond the Surface: Nutritional Interventions Integrated with Diagnostic Imaging Tools to Target and Preserve Cartilage Integrity: A Narrative Review
Biomedicines,
Год журнала:
2025,
Номер
13(3), С. 570 - 570
Опубликована: Фев. 24, 2025
This
narrative
review
provides
an
overview
of
the
various
diagnostic
tools
used
to
assess
cartilage
health,
with
a
focus
on
early
detection,
nutrition
intervention,
and
management
osteoarthritis.
Early
detection
damage
is
crucial
for
effective
patient
management.
Traditional
like
radiography
conventional
magnetic
resonance
imaging
(MRI)
sequences
are
more
suited
detecting
late-stage
structural
changes.
paper
highlights
advanced
techniques,
including
sodium
MRI,
T2
mapping,
T1ρ
imaging,
delayed
gadolinium-enhanced
MRI
cartilage,
which
provide
valuable
biochemical
information
about
composition,
particularly
glycosaminoglycan
content
its
potential
links
nutrition-related
factors
influencing
health.
Cartilage
degradation
often
linked
inflammation
measurable
via
markers
CRP
IL-6
which,
although
not
specific
breakdown,
offer
insights
into
affecting
cartilage.
In
addition
markers,
such
as
collagen
breakdown
products
aggrecan
fragments,
reflect
metabolic
changes
in
discussed.
Emerging
optical
coherence
tomography
hybrid
positron
emission
tomography–magnetic
(PET-MRI)
also
explored,
offering
high-resolution
combined
insights,
respectively.
Finally,
wearable
technology
biosensors
real-time
monitoring
osteoarthritis
progression,
well
role
artificial
intelligence
enhancing
accuracy
through
pattern
recognition
data
addressed.
While
these
hold
great
osteoarthritis,
challenges
remain
clinical
translation,
validation
larger
populations
integration
existing
workflows
personalized
treatment
strategies
cartilage-related
diseases.
Язык: Английский
Free glutaraldehyde gelatin microsphere loaded mesenchymal stem cells alleviate osteoarthritis by promoting Ext1 expression
Theranostics,
Год журнала:
2025,
Номер
15(9), С. 4135 - 4146
Опубликована: Март 10, 2025
Rationale:
Osteoarthritis
(OA)
is
a
chronic
joint
disorder
with
limited
treatment
efficacy,
necessitating
innovative
therapeutic
strategies.
This
study
explores
one-pot-synthesized
gelatin
microspheres
devoid
of
glutaraldehyde
as
novel
biomaterial
for
OA
management.
Focusing
on
the
Ext1
gene,
critical
cartilage
development
and
downregulated
in
OA,
we
investigated
its
restoration
immune
regulation
using
cultured
mesenchymal
stem
cells
(MSCs).
Methods:
patients
undergoing
knee
replacement
surgery
have
their
lateral
compartment
(remote
zone)
medial
(lesion
collected
transcriptomic
testing.
The
differential
gene
identified,
expression
regulatory
genes
examined.
MSCs
were
to
evaluate
compatibility
ability
promote
cell
attachment.
effects
overexpression,
regulation,
symptom
mitigation
through
vitro
vivo
experiments.
Results:
exhibit
decreased
area,
accompanied
by
abnormal
genes.
demonstrated
that
exhibited
excellent
facilitated
Culturing
led
enhanced
overexpression
which
crucial
growth
development.
Additionally,
regulated
responses,
contributing
reduction
symptoms.
Conclusion:
introduces
an
strategy
osteoarthritis
MSCs.
By
promoting
regulating
these
effectively
mitigate
findings
highlight
potential
this
promising
option
OA.
Язык: Английский
Surface slicing and toolpath planning for in-situ bioprinting of skin implants
Biofabrication,
Год журнала:
2024,
Номер
16(2), С. 025030 - 025030
Опубликована: Март 6, 2024
Abstract
Bioprinting
has
emerged
as
a
successful
method
for
fabricating
engineered
tissue
implants,
offering
great
potential
wound
healing
applications.
This
study
focuses
on
an
advanced
surface-based
slicing
approach
aimed
at
designing
skin
implant
specifically
in-situ
bioprinting.
The
step
plays
crucial
role
in
determining
the
layering
arrangement
of
during
printing.
By
utilizing
surface
slicing,
significant
shift
from
planar
fabrication
methods
is
achieved.
developed
methodology
involves
utilization
customized
robotic
printer
to
deliver
biomaterials.
A
multilayer
and
toolpath
generation
procedure
presented,
enabling
implants
that
incorporate
epidermal,
dermal,
hypodermal
layers.
One
notable
advantage
using
approximate
representation
native
site
avoidance
printing
effects
such
staircasing.
allows
design
non-planar
ultra-thin
ensuring
higher
degree
geometric
match
between
interface.
Furthermore,
proposed
demonstrates
superior
quality
bio-printed
hand
model,
validating
its
ability
create
toolpaths
with
complex
surfaces.
Язык: Английский
Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review
Croatian Medical Journal,
Год журнала:
2024,
Номер
65(3), С. 268 - 288
Опубликована: Июнь 1, 2024
This
review
evaluates
the
current
landscape
and
future
directions
of
regenerative
medicine
for
knee
cartilage
repair,
with
a
particular
focus
on
tissue
engineering
strategies.
In
this
context,
scaffold-based
approaches
have
emerged
as
promising
solutions
regeneration.
Synthetic
scaffolds,
while
offering
superior
mechanical
properties,
often
lack
biological
cues
necessary
effective
integration.
Natural
though
biocompatible
biodegradable,
frequently
suffer
from
inadequate
strength.
Hybrid
combining
elements
both
synthetic
natural
materials,
present
balanced
approach,
enhancing
support
functionality.
Advances
in
decellularized
extracellular
matrix
scaffolds
shown
potential
promoting
cell
infiltration
integration
native
tissues.
Additionally,
bioprinting
technologies
enabled
creation
complex,
bioactive
that
closely
mimic
zonal
organization
cartilage,
providing
an
optimal
environment
growth
differentiation.
The
also
explores
gene
therapy
editing
techniques,
including
CRISPR-Cas9,
to
enhance
repair
by
targeting
specific
genetic
pathways
involved
these
advanced
therapies
holds
promise
developing
personalized
durable
treatments
injuries
osteoarthritis.
conclusion,
underscores
importance
continued
multidisciplinary
collaboration
advance
innovative
bench
bedside
improve
outcomes
patients
damage.
Язык: Английский