3D Digital Light Process Bioprinting: Cutting-Edge Platforms for Resolution of Organ Fabrication
Materials Today Bio,
Год журнала:
2024,
Номер
29, С. 101284 - 101284
Опубликована: Окт. 2, 2024
Язык: Английский
Biomimetic multizonal scaffolds for the reconstruction of zonal articular cartilage in chondral and osteochondral defects
Bioactive Materials,
Год журнала:
2024,
Номер
43, С. 510 - 549
Опубликована: Окт. 11, 2024
Язык: Английский
Comparison of Bioengineered Scaffolds for the Induction of Osteochondrogenic Differentiation of Human Adipose-Derived Stem Cells
Bioengineering,
Год журнала:
2024,
Номер
11(9), С. 920 - 920
Опубликована: Сен. 14, 2024
Osteochondral
lesions
may
be
due
to
trauma
or
congenital
conditions.
In
both
cases,
therapy
is
limited
because
of
the
difficulty
tissue
repair.
Tissue
engineering
a
promising
approach
that
relies
on
designed
scaffolds
with
variable
mechanical
attributes
favor
cell
attachment
and
differentiation.
Human
adipose-derived
stem
cells
(hASCs)
are
very
source
in
regenerative
medicine
osteochondrogenic
potential.
Based
assumption
stiffness
influences
commitment,
we
investigated
three
different
scaffolds:
semisynthetic
animal-derived
GelMA
hydrogel,
combined
scaffold
made
rigid
PEGDA
coated
thin
layer
decellularized
plant-based
scaffold.
We
role
biomechanical
stimulations
scaffold-induced
osteochondral
differentiation
hASCs.
demonstrated
all
support
viability
spontaneous
without
any
exogenous
factors.
particular,
observed
mainly
osteogenic
commitment
higher
microenvironments,
as
one,
whereas
dense
softer
matrix,
such
hydrogel
GelMA-coated-PEGDA
scaffold,
chondrogenesis
prevailed.
can
induce
specific
by
combining
hASCs
particular
attributes.
However,
vivo
studies
needed
fully
elucidate
process
eventually
suggest
it
potential
for
medicine.
Язык: Английский
Mechanically anisotropic phantoms for magnetic resonance elastography
Magnetic Resonance in Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 3, 2024
Abstract
Purpose
Imaging
phantoms
with
known
anisotropic
mechanical
properties
are
needed
to
evaluate
magnetic
resonance
elastography
(MRE)
methods
estimate
parameters.
The
aims
of
this
study
were
fabricate
mechanically
MRE
phantoms,
characterize
their
behavior
by
direct
testing,
then
assess
the
accuracy
estimates
using
a
transversely
isotropic
nonlinear
inversion
(TI‐NLI)
algorithm.
Methods
Directionally
scaled
and
unscaled
lattices
designed
exhibit
or
properties.
Lattices
three‐dimensionally
printed
in
poly(ethelyne
glycol)
diacrylate
commercial
digital
light
processing
printer,
infilled
gelatin
form
composite
material.
Benchtop
testing
determined
two
shear
stiffnesses,
,
governing
loading
parallel
perpendicular
symmetry
axis,
analogous
Young's
moduli
.
From
these
measures,
anisotropy
=
tensile
calculated.
Three
driven
central
actuator
imaged
at
frequencies
from
300
500
Hz.
data,
TI‐NLI
algorithm
estimated
maps
Results
In
benchtop
tests,
geometrically
lattice
composites
exhibited
following
properties:
6.1
±
0.7
kPa,
0.83
0.13,
0.78
0.09}
(mean
standard
deviation).
revealed
elliptical
wavefields;
analysis
identified
median
property
ranges:
11–19
0.6–1.0,
0.8–1.6}.
Conclusion
Anisotropic
created
embedding
into
softer
matrix.
accurately
spatial
contrast
Язык: Английский