Antioxidants,
Год журнала:
2025,
Номер
14(4), С. 372 - 372
Опубликована: Март 21, 2025
Mitochondria
are
of
great
importance
in
cell
biology
since
they
major
sites
adenosine
triphosphate
(ATP)
production
and
widely
involved
different
cellular
pathways
the
response
to
stress.
During
ATP
production,
reactive
oxygen
species
(ROS)
can
be
produced.
While
a
small
amount
ROS
may
important
for
regulation
physiological
processes,
at
elevated
levels
turn
into
harmful
agents
leading
damage.
From
pathological
perspective,
it
could
particularly
interesting
focus
on
mitochondrial
function
endothelial
cells
development
aging
onset
diseases,
including
renal,
cardio-metabolic,
liver
neurodegenerative
ones.
However,
date,
there
no
surveys
which
address
above
issues.
To
fill
this
gap,
valuable
collect
recent
findings
about
role
mitochondria
function,
not
only
increase
knowledge
but
also
clinical
applications.
Here,
we
overview
most
issues
view
characterizing
as
an
innovative
potential
target
prevention
aging,
well
treatment
conditions.
Journal of Complementary and Integrative Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Diabetes
mellitus
is
a
complex
disease
in
terms
of
its
causes
and
pathophysiological
processes,
it
produces
significant
impact
on
health
leads
to
complications
that
are
difficult
manage.
World Journal of Cardiology,
Год журнала:
2025,
Номер
17(2)
Опубликована: Фев. 24, 2025
Percutaneous
coronary
intervention
(PCI),
as
an
essential
treatment
for
artery
disease,
has
significantly
improved
the
prognosis
of
patients
with
large
lesions.
However,
some
continue
to
experience
myocardial
ischemic
symptoms
post-procedure,
largely
due
microvascular
dysfunction
(CMD).
The
pathophysiological
mechanisms
CMD
are
complex
and
involve
endothelial
dysfunction,
remodeling,
reperfusion
injury,
metabolic
abnormalities.
Moreover,
components
syndrome,
including
obesity,
hyperglycemia,
hypertension,
dyslipidemia,
exacerbate
occurrence
progression
through
multiple
pathways.
This
review
systematically
summarizes
latest
research
advancements
in
after
PCI,
its
pathogenesis,
diagnostic
techniques,
management
strategies,
future
directions.
For
diagnosis,
invasive
techniques
such
flow
reserve
index
microcirculatory
resistance,
well
non-invasive
imaging
modalities
(positron
emission
tomography
cardiac
magnetic
resonance),
provide
tools
early
detection.
In
terms
management,
a
multi-level
strategy
is
emphasized,
incorporating
lifestyle
modifications
(diet,
exercise,
weight
control),
pharmacotherapy
(vasodilators,
hypoglycemic
agents,
statins,
modulators),
traditional
Chinese
medicine,
specialized
treatments
(enhanced
external
counterpulsation,
surgery,
lipoprotein
apheresis).
challenges
remain
treatment,
limitations
lack
personalized
strategies.
Future
should
focus
on
interactions
between
risks,
aiming
optimize
therapeutic
strategies
improve
long-term
post-PCI.
Antioxidants,
Год журнала:
2025,
Номер
14(4), С. 372 - 372
Опубликована: Март 21, 2025
Mitochondria
are
of
great
importance
in
cell
biology
since
they
major
sites
adenosine
triphosphate
(ATP)
production
and
widely
involved
different
cellular
pathways
the
response
to
stress.
During
ATP
production,
reactive
oxygen
species
(ROS)
can
be
produced.
While
a
small
amount
ROS
may
important
for
regulation
physiological
processes,
at
elevated
levels
turn
into
harmful
agents
leading
damage.
From
pathological
perspective,
it
could
particularly
interesting
focus
on
mitochondrial
function
endothelial
cells
development
aging
onset
diseases,
including
renal,
cardio-metabolic,
liver
neurodegenerative
ones.
However,
date,
there
no
surveys
which
address
above
issues.
To
fill
this
gap,
valuable
collect
recent
findings
about
role
mitochondria
function,
not
only
increase
knowledge
but
also
clinical
applications.
Here,
we
overview
most
issues
view
characterizing
as
an
innovative
potential
target
prevention
aging,
well
treatment
conditions.
