Cells,
Год журнала:
2024,
Номер
13(6), С. 513 - 513
Опубликована: Март 14, 2024
The
development
of
obesity
is
associated
with
substantial
modulation
adipose
tissue
(AT)
structure.
plasticity
the
AT
reflected
by
its
remarkable
ability
to
expand
or
reduce
in
size
throughout
adult
lifespan,
which
linked
vasculature.
This
increase
vasculature
could
be
mediated
differentiation
tissue-derived
stem
cells
(ASCs)
into
endothelial
(ECs)
and
form
new
microvasculature.
We
have
already
shown
that
microRNA
(miRNA)-145
regulates
ASCs
EC-like
(ECL)
cells.
Here,
we
investigated
whether
ASCs-differentiation
ECs
governed
a
miRNAs
signature
depends
on
fat
depot
location
/or
metabolic
condition
produced
obesity.
Human
ASCs,
were
obtained
from
white
surgical
procedures
lean
obese
patients,
induced
differentiate
ECL
identified
miRNA-29b-3p
both
subcutaneous
(s)ASCs
visceral
miRNA-424-5p
miRNA-378a-3p
are
involved
These
modulate
their
pro-angiogenic
effects
targeting
FGFR1,
NRP2,
MAPK1,
TGF-β2,
MAPK
signaling
pathway.
show
for
first
time
upregulation
contributes
ASCs’
directly
TGFB2
sASCs
ASCs.
Moreover,
our
results
reveal
that,
independent
sASCs’
origin
(obese/lean),
downregulation
inhibit
MAPK1
overexpress
FGFR1
respectively.
In
summary,
affect
resident
through
expression
specific
miRNAs.
Angiogenesis,
Год журнала:
2023,
Номер
26(3), С. 313 - 347
Опубликована: Апрель 15, 2023
In
multicellular
organisms,
angiogenesis,
the
formation
of
new
blood
vessels
from
pre-existing
ones,
is
an
essential
process
for
growth
and
development.
Different
mechanisms
such
as
vasculogenesis,
sprouting,
intussusceptive,
coalescent
well
vessel
co-option,
vasculogenic
mimicry
lymphangiogenesis,
underlie
vasculature.
many
pathological
conditions,
cancer,
atherosclerosis,
arthritis,
psoriasis,
endometriosis,
obesity
SARS-CoV-2(COVID-19),
developmental
angiogenic
processes
are
recapitulated,
but
often
done
so
without
normal
feedback
that
regulate
ordinary
spatial
temporal
patterns
formation.
Thus,
angiogenesis
presents
challenges
yet
opportunities
design
vascular-directed
therapies.
Here,
we
provide
overview
recent
insights
into
development
highlight
novel
therapeutic
strategies
promote
or
inhibit
to
stabilize,
reverse,
even
halt
disease
progression.
our
review,
will
also
explore
several
additional
aspects
(the
switch,
hypoxia,
angiocrine
signals,
endothelial
plasticity,
normalization,
cell
anergy)
operate
in
parallel
canonical
speculate
how
these
may
be
targeted
with
anti-angiogenic
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2436 - 2436
Опубликована: Июль 26, 2024
Adipose
tissue
(AT),
composed
mainly
of
adipocytes,
plays
a
critical
role
in
lipid
control,
metabolism,
and
energy
storage.
Once
considered
metabolically
inert,
AT
is
now
recognized
as
dynamic
endocrine
organ
that
regulates
food
intake,
homeostasis,
insulin
sensitivity,
thermoregulation,
immune
responses.
This
review
examines
the
multifaceted
adiponectin,
predominant
adipokine
released
by
AT,
glucose
fatty
acid
metabolism.
We
explore
regulatory
mechanisms
its
physiological
effects
potential
therapeutic
target
for
metabolic
diseases
such
type
2
diabetes,
cardiovascular
disease
liver
disease.
Furthermore,
we
analyze
impact
various
dietary
patterns,
specific
nutrients,
physical
activities
on
adiponectin
levels,
highlighting
strategies
to
improve
health.
Our
comprehensive
provides
insights
into
functions
importance
maintaining
systemic
homeostasis.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 16, 2025
ABSTRACT
Inadequate
angiogenesis
in
obesogenic
adipose
tissue
(AT)
has
been
implicated
disrupted
adipogenesis
and
metabolic
disorders.
Yet,
key
cellular
molecular
regulators
of
AT
remain
largely
unidentified.
This
study
sought
to
identify
the
dysregulated
elements
within
Vascular
Endothelial
Growth
Factor
(VEGF)
Platelet-Derived
(PDGF)
systems
during
obesity
progression.
We
employ
a
mouse
model,
comprising
both
male
female
mice,
investigate
changes
VEGF/PDGF
concentration
their
receptor
distribution
short-
long-term
weight
gain
loss.
Our
results
reveal
pronounced
sex-specific
differences
progression,
with
mice
exhibiting
distinct
angiogenic
ligand
profiles
under
identical
dietary
interventions.
data
also
lays
groundwork
for
developing
computational
models
signaling
networks
AT,
allowing
simulation
complex
biological
interactions
prediction
therapeutic
outcomes.
Nutrients,
Год журнала:
2023,
Номер
15(7), С. 1722 - 1722
Опубликована: Март 31, 2023
White
adipose
tissue
(AT)
dysfunction
plays
an
important
role
in
the
development
of
cardiometabolic
alterations
associated
with
obesity.
AT
is
characterized
by
loss
expansion
capacity
AT,
increment
adipocyte
hypertrophy,
and
changes
secretion
profile
cells,
accumulation
macrophages
inflammation.
Since
not
all
people
excess
adiposity
develop
comorbidities,
it
necessary
to
find
simple
tools
that
can
evidence
allow
detection
those
potential
metabolic
alterations.
This
review
focuses
on
current
pathophysiological
mechanisms
white
emerging
measurements
assess
its
functionality.
Clinical Kidney Journal,
Год журнала:
2023,
Номер
17(1)
Опубликована: Ноя. 13, 2023
Abstract
The
prevalence
of
obesity
has
tripled
over
the
past
five
decades.
Obesity,
especially
visceral
obesity,
is
closely
related
to
hypertension,
increasing
risk
primary
(essential)
hypertension
by
65%–75%.
Hypertension
a
major
factor
for
cardiovascular
disease,
leading
cause
death
worldwide,
and
its
rapidly
following
pandemic
rise
in
obesity.
Although
causal
relationship
between
high
blood
pressure
(BP)
well
established,
detailed
mechanisms
such
association
are
still
under
research.
For
more
than
30
years
sympathetic
nervous
system
(SNS)
kidney
sodium
reabsorption
activation,
secondary
insulin
resistance
compensatory
hyperinsulinemia,
have
been
considered
as
mediators
elevated
BP
However,
experimental
clinical
data
show
that
severe
hyperinsulinemia
can
occur
absence
BP,
challenging
key
linking
hypertension.
purpose
Part
1
this
review
summarize
available
on
recently
emerging
believed
contribute
obesity-related
through
increased
volume
expansion,
as:
physical
compression
perirenal/intrarenal
fat
overactivation
systemic/renal
SNS
renin–angiotensin–aldosterone
system.
role
hyperleptinemia,
impaired
chemoreceptor
baroreceptor
reflexes,
perivascular
also
discussed.
Specifically
targeting
these
may
pave
way
new
therapeutic
intervention
treatment
context
‘precision
medicine’
principles,
which
will
be
discussed
2.
Life,
Год журнала:
2023,
Номер
13(3), С. 717 - 717
Опубликована: Март 6, 2023
Chronic
wounds
represent
nowadays
a
major
challenge
for
both
clinicians
and
researchers
in
the
regenerative
setting.
Obesity
represents
one
of
comorbidities
patients
affected
by
chronic
ulcers
therefore
diverse
studies
aimed
at
assessing
possible
links
between
these
two
morbid
conditions
are
currently
ongoing.
In
particular,
adipose
tissue
has
recently
been
described
as
having
metabolic
endocrine
functions
rather
than
serving
mere
fat
storage
deposit.
this
setting,
adipose-derived
stem
cells,
peculiar
subset
mesenchymal
stromal/stem
cells
(MSCs)
located
tissue,
have
demonstrated
to
possess
immunological
with
key
role
regulating
adipocyte
function
skin
regeneration.
The
aim
present
review
is
give
an
overview
most
recent
findings
on
wound
healing,
special
focus
biology
obesity.
