Ferroptosis: a novel mechanism of cell death in ophthalmic conditions
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 27, 2024
Ferroptosis,
a
new
type
of
programmed
cell
death
proposed
in
recent
years,
is
characterized
mainly
by
reactive
oxygen
species
and
iron-mediated
lipid
peroxidation
differs
from
death,
such
as
apoptosis,
necrosis,
autophagy.
Ferroptosis
associated
with
variety
physiological
pathophysiological
processes.
Recent
studies
have
shown
that
ferroptosis
can
aggravate
or
reduce
the
occurrence
development
diseases
targeting
metabolic
pathways
signaling
tumors,
ischemic
organ
damage,
other
degenerative
related
to
peroxidation.
Increasing
evidence
suggests
closely
linked
onset
progression
various
ophthalmic
conditions,
including
corneal
injury,
glaucoma,
age-related
macular
degeneration,
diabetic
retinopathy,
retinal
detachment,
retinoblastoma.
Our
review
current
research
on
reveals
significant
advancements
our
understanding
pathogenesis,
aetiology,
treatment
these
conditions.
Язык: Английский
SARS-CoV-2 S-protein expression drives syncytia formation in endothelial cells
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 28, 2025
SARS-CoV-2
is
a
viral
infection,
best
studied
in
the
context
of
epithelial
cell
infection.
Epithelial
cells,
when
infected
with
express
S-protein,
which
causes
host
cells
to
fuse
together
into
large
multi-nucleated
known
as
syncytia.
Because
infections
also
frequently
present
cardiovascular
phenotypes,
we
sought
understand
if
S-protein
expression
would
result
syncytia
formation
endothelial
cells.
was
sufficient
induce
an
average
10%
all
forming
6
nuclei
per
after
72
h
expression.
Formation
associated
gaps
between
suggesting
potential
for
compromise
barrier
function.
Inhibition
myosin
light
chain
kinase
(MLCK),
but
not
Rho-associated
protein
kinase,
inhibited
syncytia,
role
MLCK
formation.
Further
supporting
cellular
contractility
formation,
observed
reduction
occurrence
grown
on
substrates
reduced
stiffness.
are
exposed
physiological
forces
due
blood
flow,
examined
effects
cyclic
biaxial
stretch
and
fluid
shear
stress.
While
did
affect
stress
were
more
resistant
Finally,
that
suitable
infection
replication,
Our
studies
indicate
addition
should
be
considered
target
driver
COVID-19-associated
pathology.
Язык: Английский
Unveiling ferroptosis: a new frontier in skin disease research
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 4, 2024
Ferroptosis,
a
form
of
regulated
cell
death
distinct
from
apoptosis,
necrosis,
and
autophagy,
is
increasingly
recognized
for
its
role
in
skin
disease
pathology.
Characterized
by
iron
accumulation
lipid
peroxidation,
ferroptosis
has
been
implicated
the
progression
various
conditions,
including
psoriasis,
photosensitive
dermatitis,
melanoma.
This
review
provides
an
in-depth
analysis
molecular
mechanisms
underlying
compares
cellular
effects
with
other
forms
context
health
disease.
We
systematically
examine
five
specific
diseases,
ichthyosis,
polymorphous
light
eruption
(PMLE),
vitiligo,
melanoma,
detailing
influence
on
pathogenesis
progression.
Moreover,
we
explore
current
clinical
landscape
ferroptosis-targeted
therapies,
discussing
their
potential
managing
treating
diseases.
Our
aim
to
shed
therapeutic
modulating
research
practice.
Язык: Английский