Prognostic Impact and Therapeutic Potential of CDC20 in Cervical Cancer: Insights from Clinical and Experimental Analyses DOI Creative Commons
Feng Xian, Qi Zhu, Guojun Zhang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Abstract CDC20 has been identified as an oncogene involved in the development and prognosis of various cancers, yet its role cervical cancer remains unclear. This study aimed to evaluate expression tissues clinical significance. We conducted a retrospective analysis 249 patients diagnosed at Nanchong Central Hospital from January December 2022. Immunohistochemistry was used assess expression, statistical methods compared clinicopathological characteristics. Survival employed Kaplan-Meier method, Cox regression survival risk factors. Additionally, siRNA knock down HeLa cells examine effects on proliferation, invasion, migration. Results indicated that significantly higher (61.85%) adjacent normal (7.5%) (p < 0.05). High associated with poorer overall survival, particularly specific subgroups 0.05) independent factor Silencing inhibited cell proliferation while xenograft models demonstrated reduced tumor growth inhibition 0.01). may serve valuable prognostic biomarker therapeutic target for cancer.

Язык: Английский

Caspase-Linked Programmed Cell Death in Prostate Cancer: From Apoptosis, Necroptosis, and Pyroptosis to PANoptosis DOI Creative Commons
Minggang Zhu, Di Liu, Guoqiang Liu

и другие.

Biomolecules, Год журнала: 2023, Номер 13(12), С. 1715 - 1715

Опубликована: Ноя. 28, 2023

Prostate cancer (PCa) is a complex disease and the cause of one highest cancer-related mortalities in men worldwide. Annually, more than 1.2 million new cases are diagnosed globally, accounting for 7% newly cancers men. Programmed cell death (PCD) plays an essential role removing infected, functionally dispensable, or potentially neoplastic cells. Apoptosis canonical form PCD with no inflammatory responses elicited, close relationship between apoptosis PCa has been well studied. Necroptosis pyroptosis two lytic forms that result release intracellular contents, which induce responses. An increasing number studies have confirmed necroptosis also closely related to occurrence progression PCa. Recently, novel named PANoptosis, combination apoptosis, necroptosis, pyroptosis, revealed attached connection among them may be promising target Apoptosis, PANoptosis good examples better understand mechanism underlying This review aims summarize emerging roles therapeutic potential

Язык: Английский

Процитировано

11
The oncogenic role of EIF4A3/CDC20 axis in the endometrial cancer DOI
Lin Yan, Lili Kong, Yiting Zhao

и другие.

Journal of Molecular Medicine, Год журнала: 2024, Номер unknown

Опубликована: Сен. 24, 2024

Язык: Английский

Процитировано

1
Programmed Cell Death in Prostate Cancer: From Apoptosis, Necroptosis, and Pyroptosis to PANoptosis DOI Open Access
Minggang Zhu, Di Liu, Guoqiang Liu

и другие.

Опубликована: Окт. 19, 2023

Prostate cancer (PCa) is a complex disease and the cause of one highest cancer-related mortalities in men worldwide. Annually, more than 1.2 million new cases are diagnosed globally, accounting for 7% newly cancers men. Programmed cell death (PCD) plays an essential role removing infected, functionally dispensable or potentially neoplastic cells. Apoptosis canonical form PCD with no inflammatory responses elicited, close relationship between apoptosis PCa has been well studied. Necroptosis pyroptosis two lytic forms resulting release intracellular contents, which induces responses. An increasing number studies have confirmed that necroptosis also closely related to occurrence progression PCa. Recently, novel named PANoptosis, combination apoptosis, necroptosis, pyroptosis, revealed attached connection among them may be promising target Apoptosis, PANoptosis good examples better understand mechanism underlying This review aims summarize emerging roles therapeutic potential

Язык: Английский

Процитировано

3
CDC20 Holds Novel Regulation Mechanism in RPA1 during Different Stages of DNA Damage to Induce Radio-Chemoresistance DOI Open Access
Yang Gao, Pengbo Wen,

Chenran Shao

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(15), С. 8383 - 8383

Опубликована: Авг. 1, 2024

Targeting CDC20 can enhance the radiosensitivity of tumor cells, but function and mechanism on DNA damage repair response remains vague. To examine that issue, cell lines, including KYSE200, KYSE450, HCT116, were utilized to detect expression, function, underlying in radio-chemoresistance. Western blot immunofluorescence staining employed confirm expression location, radiation could upregulate nucleus. The homologous recombination (HR) non-homologous end joining (NHEJ) reporter gene systems explore impact repair, indicating promote HR radio/chemo-resistance. In early stages damage, stabilizes RPA1 protein through protein-protein interactions, activating ATR-mediated signaling cascade, thereby aiding genomic repair. later stages, assists subsequent steps by ubiquitin-mediated degradation RPA1. CCK-8 colony formation assay used vitality proliferation, targeting exacerbate increase levels caused cisplatin or etoposide. A xenograft model was conducted BALB/c-nu/nu mice vivo, confirming vitro results. conclusion, this study provides further validation potential clinical significance as a strategy overcome radio-chemoresistance via uncovering novel role regulating during

Язык: Английский

Процитировано

0
Prognostic Impact and Therapeutic Potential of CDC20 in Cervical Cancer: Insights from Clinical and Experimental Analyses DOI Creative Commons
Feng Xian, Qi Zhu, Guojun Zhang

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Abstract CDC20 has been identified as an oncogene involved in the development and prognosis of various cancers, yet its role cervical cancer remains unclear. This study aimed to evaluate expression tissues clinical significance. We conducted a retrospective analysis 249 patients diagnosed at Nanchong Central Hospital from January December 2022. Immunohistochemistry was used assess expression, statistical methods compared clinicopathological characteristics. Survival employed Kaplan-Meier method, Cox regression survival risk factors. Additionally, siRNA knock down HeLa cells examine effects on proliferation, invasion, migration. Results indicated that significantly higher (61.85%) adjacent normal (7.5%) (p < 0.05). High associated with poorer overall survival, particularly specific subgroups 0.05) independent factor Silencing inhibited cell proliferation while xenograft models demonstrated reduced tumor growth inhibition 0.01). may serve valuable prognostic biomarker therapeutic target for cancer.

Язык: Английский

Процитировано

0