High CXCL8 expression predicting poor prognosis in triple-negative breast cancer DOI Creative Commons

Sumin Tang,

Yuqing Zhang,

Liying Song

и другие.

Anti-Cancer Drugs, Год журнала: 2025, Номер 36(3), С. 246 - 252

Опубликована: Янв. 6, 2025

Triple-negative breast cancer (TNBC) is highly prone to early relapse and metastasis following standard treatment. CXCL8 a key factor in tumor invasion metastasis, but its role TNBC prognosis clinicopathological correlations remains poorly understood. This study investigated expression clinical significance develop prognostic nomogram for guiding intensive treatment follow-up strategies. Public datasets from the gene omnibus public platform were analyzed assess expression. Additionally, paraffin-embedded specimens collected our hospital examined using immunohistochemistry explore relationship between features. Survival analysis was performed evaluate whether serves as an unfavorable biomarker patients. Univariate Cox regression conducted identify factors. Based on these findings, developed predict progression risk. significantly higher tissues than adjacent normal ( P < 0.05). Among 122 patients, 46 CXCL8-positive 76 CXCL8-negative. associated with N stage Progression-free survival (PFS) markedly shorter group compared CXCL8-negative 0.001). identified N1-3, M1, positivity significant risk factors disease progression. A incorporating variables (N, M, CXCL8) constructed PFS. Time-dependent receiver operating characteristic curve at 12-, 36-, 48-month demonstrated strong predictive performance, area under values of 0.857, 0.839, 0.795, respectively. expressed promotes lymphatic serving factor. The offers valuable tool personalized strategies

Язык: Английский

High CXCL8 expression predicting poor prognosis in triple-negative breast cancer DOI Creative Commons

Sumin Tang,

Yuqing Zhang,

Liying Song

и другие.

Anti-Cancer Drugs, Год журнала: 2025, Номер 36(3), С. 246 - 252

Опубликована: Янв. 6, 2025

Triple-negative breast cancer (TNBC) is highly prone to early relapse and metastasis following standard treatment. CXCL8 a key factor in tumor invasion metastasis, but its role TNBC prognosis clinicopathological correlations remains poorly understood. This study investigated expression clinical significance develop prognostic nomogram for guiding intensive treatment follow-up strategies. Public datasets from the gene omnibus public platform were analyzed assess expression. Additionally, paraffin-embedded specimens collected our hospital examined using immunohistochemistry explore relationship between features. Survival analysis was performed evaluate whether serves as an unfavorable biomarker patients. Univariate Cox regression conducted identify factors. Based on these findings, developed predict progression risk. significantly higher tissues than adjacent normal ( P < 0.05). Among 122 patients, 46 CXCL8-positive 76 CXCL8-negative. associated with N stage Progression-free survival (PFS) markedly shorter group compared CXCL8-negative 0.001). identified N1-3, M1, positivity significant risk factors disease progression. A incorporating variables (N, M, CXCL8) constructed PFS. Time-dependent receiver operating characteristic curve at 12-, 36-, 48-month demonstrated strong predictive performance, area under values of 0.857, 0.839, 0.795, respectively. expressed promotes lymphatic serving factor. The offers valuable tool personalized strategies

Язык: Английский

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