Extracellular Vesicles as Mediators of Endothelial Dysfunction in Cardiovascular Diseases

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1008 - 1008

Опубликована: Янв. 24, 2025

This comprehensive review aims to provide a thorough overview of the vital role that extracellular vesicles (EVs) play in endothelial dysfunction, particularly emphasizing how physiological factors—such as sex and aging—along with significant cardiovascular risk factors, influence this process. The covers studies ranging from first description EVs 1945 contemporary insights into their biological roles intercellular signaling dysfunction. A analysis peer-reviewed articles reviews indexed PubMed database was conducted compile information. Initially, Medical Subject Headings (MeSH) terms included keywords aimed at providing general knowledge about regulation signaling, such “extracellular vesicles”, “endothelium”, “intercellular signaling”. Subsequently, related pathophysiological implications EV interactions dysfunction disease were added, including “cardiovascular disease”, “sex”, “aging”, “atherosclerosis”, “obesity”, “diabetes”. Additionally, potential applications explored using MeSH “biomarker”, “therapeutic strategy”. results bibliographical reveal have capacity induce various cellular responses within system complex landscape disease. composition cargo is subject modification by conditions sex, aging, which result regulatory on function neighboring cells when released dysfunctional endothelium. Moreover, data suggest field still requires further exploration, biology continuously evolving, presenting dynamic engaging area for research. deeper understanding molecular involved EV–endothelium could yield valuable biomarkers monitoring progression facilitate development innovative bioengineered therapeutic strategies enhance patient outcomes.

Язык: Английский

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Exosomes in cartilage microenvironment regulation and cartilage repair

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Март 5, 2025

Osteoarthritis (OA) is a debilitating disease that predominantly impacts the hip, hand, and knee joints. Its pathology defined by progressive degradation of articular cartilage, formation bone spurs, synovial inflammation, resulting in pain, joint function limitations, substantial societal familial burdens. Current treatment strategies primarily target pain alleviation, yet improved interventions addressing underlying are scarce. Recently, exosomes have emerged as subject growing interest OA therapy. Numerous studies investigated to offer promising therapeutic approaches for through diverse vivo vitro models, elucidating mechanisms which from various cell sources modulate cartilage microenvironment promote repair. Preclinical investigations demonstrated regulatory effects originating human cells, including mesenchymal stem cells (MSC), fibroblasts, chondrocytes, macrophages, derived Chinese herbal medicines, on modulation repair signaling pathways. Additionally, encompass matrix, proliferation migration autophagy, apoptosis, mitigation oxidative stress. An increasing number exosome carrier scaffolds under development. Our review adopts multidimensional approach enhance comprehension pivotal functions exerted sourced types OA. Ultimately, our aim pinpoint targets capable regulating facilitating

Язык: Английский

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Exosomes in Ovarian Cancer: Towards Precision Oncology

Pharmaceuticals, Год журнала: 2025, Номер 18(3), С. 371 - 371

Опубликована: Март 5, 2025

Background: Identification of targetable biomarkers to improve early disease detection and overall patient outcomes is becoming an urgent need in clinical oncology. Ovarian cancer (OC) has one the highest mortality rates among gynecological cancers. It asymptomatic almost always diagnosed at advanced stage (III or IV), leading a 5-year survival rate approximately 35%. Methods: Current therapeutic approaches for OC are very limited mainly consist cytoreductive surgery cisplatin plus taxane-based chemotherapy. No gender tumor specific known. Exosomes, lipid bilayer vesicles endocytic origin secreted by most cell types, represent sources information their involvement onset progression many diseases. Hence, research on exosome contents as tools targets precise oncology therapy provides knowledge essential improving diagnosis prognosis disease. Results: This review attempts give overview how exosomes implicated ovarian carcinoma pathogenesis trigger further exosome-based investigations aimed developing fine-tuning diagnostic methodologies. Conclusions: investigate drugs advance understanding, treatment plans, create personalized strategies, ensure safety, speed up translation increase patients’ quality life. Papers published PubMed Web Science databases last five years (2020–2024) were used bibliographic source.

Язык: Английский

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Exosomes and their roles in major depressive disorder: an overview of the research progress and perspectives

Deleted Journal, Год журнала: 2025, Номер unknown, С. 100035 - 100035

Опубликована: Март 1, 2025

Язык: Английский

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Mesenchymal stem cell exosomes therapy for the treatment of traumatic brain injury: mechanism, progress, challenges and prospects

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 11, 2025

Язык: Английский

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