Nanometerizing Taxifolin Into Selenized Liposomes to Ameliorate Its Hypoglycemic Effect by Optimizing Drug Release and Bioavailability
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2225 - 2240
Опубликована: Фев. 1, 2025
Diabetes
mellitus
(DM)
remains
a
significant
health
challenge,
with
traditional
treatments
often
failing
to
provide
lasting
solutions.
Taxifolin
(Tax),
potential
phytomedicine
antioxidant
and
anti-hyperglycemic
properties,
suffers
from
low
water
solubility
poor
bioavailability,
necessitating
advanced
delivery
systems.
This
study
aims
nanometerize
taxifolin
(Tax)
into
selenized
liposomes
(Tax-Se@LPs)
for
enhanced
oral
hypoglycemic
effect.
Tax-Se@LPs
were
fabricated
through
thin-film
hydration/in
situ
reduction
technique.
The
resulting
nanomedicine
was
characterized
in
vitro
release
studies,
pharmacokinetic
pharmacodynamic
evaluations,
cellular
uptake
assays,
formulation
stability
tests.
optimized
demonstrated
an
average
particle
size
of
185.3
nm
entrapment
efficiency
95.25%
after
optimization.
In
studies
revealed
that
exhibited
slower
more
sustained
profile
compared
conventional
liposomes,
favoring
gastrointestinal
drug
absorption.
Pharmacokinetic
evaluations
normal
rats
indicated
achieved
relative
bioavailability
216.65%,
significantly
higher
than
Tax
suspensions
unmodified
liposomes.
Furthermore,
diabetic
GK
rats,
resulted
maximal
blood
glucose
46.8%
therapeutic
duration
other
formulations.
Cellular
tests
manifested
selenization
altered
the
internalization
mechanisms
while
preserving
their
absorption
aptness
by
intestinal
epithelial
cells.
physiological
also
reinforced
selenization.
Overall,
not
only
improve
but
enhance
its
efficacy.
These
findings
underscore
as
promising
strategy
DM
management.
Язык: Английский
Pharmacokinetics of the drug Amoxyantar in pigs
Legal regulation in veterinary medicine,
Год журнала:
2024,
Номер
3, С. 98 - 101
Опубликована: Окт. 18, 2024
The
article
presents
the
results
of
pharmacokinetic
studies
drug
Amoxiyantar
in
pigs.
obtained
indicate
that
amoxicillin
is
distributed
throughout
tissues
animals,
providing
therapeutic
concentrations
studied
dosage,
ensuring
effective
distribution
organs
and
body
pigs,
also
confirm
bioavailability
succinic
acid
with
a
high
concentration
blood
plasma
for
an
average
two
hours.
Based
on
determining
dynamics
excretion
residual
amounts
amoxicillin,
it
was
detected
only
one
animal
kidneys
at
54.9
μg/kg
muscle
tissue
25.2
μg/kg.
In
remaining
samples
pigs
days
after
application
drug,
as
well
all
from
sixth
day
to
18th
not
detected.
Язык: Английский