Environment-by-PGS Interaction in the Classical Twin Design: An Application to Childhood Anxiety and Negative Affect DOI Creative Commons
Susanne Bruins, Jouke‐Jan Hottenga, Michael C. Neale

и другие.

Multivariate Behavioral Research, Год журнала: 2023, Номер 59(6), С. 1198 - 1210

Опубликована: Июль 13, 2023

One type of genotype-environment interaction occurs when genetic effects on a phenotype are moderated by an environment; or environmental genes. Here we outline these types models, and propose test based the classical twin design, which includes observed variables (polygenic scores: PGSs) that account for part variance phenotype. We introduce environment-by-PGS results simulation study to address statistical power parameter recovery. Next, apply model empirical data anxiety negative affect in children. The detect depends heritability phenotype, strength PGS. indicate under realistic conditions sample size, interaction, is viable approach interaction. In 7-year-old children, defined two PGS largest association studies 2 traits genetically correlated childhood affect, namely major depression (MDD) intelligence (IQ). find common influences amplified children with lower IQ-PGS.

Язык: Английский

Editorial: Understanding the Nature of Attention Problems in Neurofibromatosis Type 1: Clinical and Research Implications DOI
Alecia C. Vogel

Journal of the American Academy of Child & Adolescent Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

0
Environment-by-PGS Interaction in the Classical Twin Design: An Application to Childhood Anxiety and Negative Affect DOI Creative Commons
Susanne Bruins, Jouke‐Jan Hottenga, Michael C. Neale

и другие.

Multivariate Behavioral Research, Год журнала: 2023, Номер 59(6), С. 1198 - 1210

Опубликована: Июль 13, 2023

One type of genotype-environment interaction occurs when genetic effects on a phenotype are moderated by an environment; or environmental genes. Here we outline these types models, and propose test based the classical twin design, which includes observed variables (polygenic scores: PGSs) that account for part variance phenotype. We introduce environment-by-PGS results simulation study to address statistical power parameter recovery. Next, apply model empirical data anxiety negative affect in children. The detect depends heritability phenotype, strength PGS. indicate under realistic conditions sample size, interaction, is viable approach interaction. In 7-year-old children, defined two PGS largest association studies 2 traits genetically correlated childhood affect, namely major depression (MDD) intelligence (IQ). find common influences amplified children with lower IQ-PGS.

Язык: Английский

Процитировано

1