Signal Transduction and Targeted Therapy,
Год журнала:
2025,
Номер
10(1)
Опубликована: Янв. 7, 2025
Abstract
Oxidative
stress
plays
a
crucial
role
in
organ
aging
and
related
diseases,
yet
the
endogenous
regulators
involved
remain
largely
unknown.
This
work
highlights
importance
of
metabolic
homeostasis
protecting
against
oxidative
large
intestine.
By
developing
low-input
user-friendly
pipeline
for
simultaneous
profiling
five
distinct
cysteine
(Cys)
states,
including
free
SH,
total
Cys
oxidation
(Sto),
sulfenic
acid
(SOH),
S
-nitrosylation
(SNO),
-glutathionylation
(SSG),
we
shed
light
on
redox
modification
stoichiometries
signaling
with
regional
resolution
gut
monkeys.
Notably,
proteins
modified
by
SOH
SSG
were
associated
primarily
cell
adhesion.
In
contrast,
SNO-modified
immunity.
Interestingly,
observed
that
Sto
levels
ranged
from
0.97%
to
99.88%,
exhibiting
two
peaks
increasing
age.
Crosstalk
analysis
revealed
numerous
age-related
metabolites
potentially
modulating
modifications.
elucidated
fumarate
alleviating
intestinal
dextran
sulfate
sodium
(DSS)-induced
colitis
mouse
model.
Our
findings
showed
treatment
promotes
recovery
several
types,
pathways,
genes
regulation.
Calorie
restriction
(CR)
is
known
strategy
stress.
Two-month
CR
intervention
led
many
antioxidative
reshaped
redoxome.
decodes
complexities
redoxomics
during
non-human
primates
identifies
key
signaling.
Biogerontology,
Год журнала:
2024,
Номер
25(6), С. 899 - 922
Опубликована: Авг. 23, 2024
The
gut
microbiota
(GM)
produces
various
molecules
that
regulate
the
physiological
functionality
of
brain
through
gut-brain
axis
(GBA).
Studies
suggest
alteration
in
GBA
may
lead
to
onset
and
progression
neurological
dysfunctions.
Moreover,
aging
is
one
prominent
causes
contribute
GBA.
With
age,
GM
undergoes
a
shift
population
size
species
microflora
leading
changes
their
secreted
metabolites.
These
also
hamper
communications
among
HPA
(hypothalamic-pituitary-adrenal),
ENS
(enteric
nervous
system),
ANS
(autonomic
system).
A
therapeutic
intervention
has
recently
gained
attention
improving
health
maintaining
communication
between
calorie
restriction
(CR),
which
plays
critical
role
autophagy
neurogenesis
processes.
However,
its
strict
regime
lifelong
commitment
pose
challenges.
need
produce
similar
beneficial
effects
CR
without
having
rigorous
compliance.
This
led
an
exploration
mimetics
(CRMs)
could
mimic
CR's
functions
limiting
diet,
providing
long-term
benefits.
CRMs
ensure
efficient
functioning
bacteria
metabolites
i.e.,
short-chain
fatty
acids,
bile
neurotransmitters.
particularly
for
elderly
individuals,
as
deteriorates
with
age
body's
ability
digest
toxic
accumulates
declines.
In
this
review,
we
have
explored
effect
extending
lifespan
by
enhancing
on
metabolite
production,
conditions,
dysfunctions
including
neurodegenerative
disorders.
IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Intermittent
fasting,
a
cleansing
activity
that
severely
restricts
calorie
intake,
is
an
effective
means
of
activating
autophagy.
As
dietary
pattern,
intermittent
fasting
can
delay
aging
and
reduce
the
risk
age-related
diseases.
helps
maintain
homeostasis
body
through
series
hormonal
metabolic
changes,
protecting
variety
diseases
preventing
chronic
And
it
has
been
shown
to
improve
efficacy
weight
loss
obesity-related
non-alcoholic
fatty
liver
disease
health
indicators.
There
are
still
some
challenges
in
area
fasting’s
effects,
further
long-term
clinical
studies
needed.
Aging advances.,
Год журнала:
2024,
Номер
1(2), С. 118 - 134
Опубликована: Дек. 1, 2024
Aging
is
a
complex
biological
process
characterized
by
gradual
deterioration
in
physiological
activities,
contributing
to
an
elevated
risk
of
different
age-associated
malignancies,
including
cancer.
The
current
review
paper
aims
elucidate
the
association
between
hallmarks
aging
and
parallel
development
Various
cellular
molecular
mechanisms
underlying
such
as
senescence,
genomic
instability,
telomere
shortening
play
significant
role
accumulation
genetic
mutations
disruption
activities.
It
has
also
discussed
immune
system’s
aging,
indicating
how
age-linked
dysfunction
compromises
body’s
capacity
recognize
eradicate
pre-tumorous
cells,
thus
promoting
cancer
advancement.
This
examines
affects
tumor
microenvironment,
where
age-related
alterations
stromal
extracellular
matrix
factors
lead
conditions
that
promote
growth
proliferation.
Furthermore,
it
discusses
concept
“accelerated
aging”
survivors,
highlighting
negative
effects
its
therapy
intensify
process,
resulting
greater
physical
cognitive
decline.
explores
prospect
new
therapies
target
aging-related
processes
ameliorate
outcomes.
Overall,
underscores
need
for
ongoing
interdisciplinary
research
understand
relationship
cancer,
ultimately
aiming
develop
more
effective
prevention
treatment
approaches.
Cellular and Molecular Neurobiology,
Год журнала:
2024,
Номер
44(1)
Опубликована: Окт. 16, 2024
Aging,
an
inevitable
physiological
process
leading
to
a
progressive
decline
in
bodily
functions,
has
been
abundantly
researched
domain
with
studies
attempting
slow
it
down
and
reduce
its
debilitating
effects.
Investigations
into
the
cellular
molecular
pathways
associated
aging
have
allowed
formulation
of
therapeutic
strategies.
Of
these,
caloric
restriction
(CR)
implicated
for
role
promoting
healthy
by
modulating
key
targets
like
Insulin/IGF-1,
mTOR,
sirtuins.
However,
CR
requires
dedication
commitment
strict
regimen
which
poses
difficulty
maintaining
consistency.
To
maneuver
around
cumbersome
diets,
Caloric
Restriction
Mimetics
(CRMs)
emerged
as
promising
alternatives
mimicking
beneficial
effects
CR.
This
review
elucidates
foundations
enabling
CRMs
rapamycin,
metformin,
resveratrol,
spermidine,
many
more
function
suitable
anti-aging
molecules.
Moreover,
explores
clinical
trials
(retrieved
from
clinicaltrials.gov
database)
aimed
at
demonstrating
efficacy
effective
candidates
against
age-related
neurodegenerative
diseases
such
Alzheimer's
disease
Parkinson's
disease.
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Окт. 24, 2024
Intermittent
fasting
(IF)
has
demonstrated
extensive
health
benefits
through
the
regulation
of
fatty
acid
metabolism
and
modulation
neuroimmune
microenvironment,
primarily
via
activation
key
signaling
pathways
such
as
AMP-activated
protein
kinase
(AMPK)
sirtuin
1
(SIRT1).
IF
not
only
facilitates
oxidation
improves
metabolic
health,
but
also
enhances
mitochondrial
function,
mitigates
oxidative
stress,
promotes
autophagy,
inhibits
apoptosis
ferroptosis.
These
mechanisms
contribute
to
its
substantial
preventive
therapeutic
potential
in
various
conditions,
including
neurodegenerative
disorders
Alzheimer’s
Parkinson’s
diseases,
autoimmune
neurotraumatic
conditions.
While
supportive
evidence
been
obtained
from
animal
models
preliminary
clinical
studies,
further
large-scale,
long-term
randomized
controlled
trials
are
imperative
establish
safety
evaluate
efficacy
comprehensively.
Journal of Biochemical and Molecular Toxicology,
Год журнала:
2024,
Номер
38(11)
Опубликована: Окт. 30, 2024
ABSTRACT
Caloric
restriction
mimetics
mimic
the
beneficial
effects
of
dietary
approaches,
such
as
caloric
without
limiting
intake.
Chlorogenic
acid
(CGA)
acts
a
mimetic;
however,
its
neuroprotective
mechanisms
remain
ambiguous.
Therefore,
in
this
study,
we
aimed
to
elucidate
CGA
on
SH‐SY5Y
cells
treated
with
amyloid‐beta
(Aβ)1‐42.
Aβ1‐42
(1.25
μM)
induced
oxidative
stress
by
significantly
increasing
pro‐oxidant
levels
and
decreasing
antioxidant
cells.
Additionally,
it
decreased
Na
+
/K
‐ATPase
Ca
2+
ion
transporter
activities
enhanced
acetylcholinesterase
activity.
However,
(100
reversed
these
Aβ1‐42‐induced
changes
Overall,
exerted
against
impaired
activities,
serving
promising
therapeutic
candidate
for
neurodegenerative
diseases,
Alzheimer's
disease.
Molecules,
Год журнала:
2024,
Номер
29(24), С. 5893 - 5893
Опубликована: Дек. 13, 2024
Bee
Pollen
(BP)
has
many
advantageous
properties
relying
on
its
multitargeting
potential,
a
new
tendency
in
managing
challenging
illnesses.
In
cancer
and
neurodegeneration,
the
multiple
effects
of
BP
could
be
unequaled
importance
need
further
investigation.
Although
still
limited,
available
data
interestingly
spotlights
some
floral
sources
with
promising
activities
line
this
Adopting
scoping
review
methodology,
we
have
identified
crucial
bioactivities
that
are
widely
recognized
to
individual
compounds
but
remain
completely
untapped
valuable
bee
cocktail.
A
wide
range
these
been
recently
found
endowed
great
potential
modulating
pivotal
processes
neurodegeneration
pathophysiology.
addition,
ubiquitous
only
isolated,
while
number
studied
BPs
remains
extremely
limited
compared
endless
pool
plant
species
worldwide.
We
also
elucidated
clinical
profits
from
perspectives
impeded
by
hurdles
such
as
bioavailability
phytocompounds,
diversity
lack
phytochemical
standardization
BP,
difficulty
selective
targeting
pathophysiological
mechanisms.
finally
present
interesting
insights
guide
future
research
pave
way
for
urgently
needed
simplified
investigations.
