Sexual dimorphism in periodontal inflammation: A cross‐sectional study
Journal of Periodontology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
Abstract
Background
The
purpose
of
the
present
study
was
to
evaluate
role
sexual
dimorphism
(SD)
in
clinical
manifestation
plaque‐induced
periodontal
inflammation
by
analyzing
association
between
patient‐related
factors
and
full‐mouth
prevalence
bleeding
on
probing
(BOP%)
within
2
cohorts
male
female
individuals.
Methods
Data
BOP
(dichotomously
recorded
as
present/absent
after
assessment
depth
[PD])
were
retrospectively
obtained
from
files
adult
patients
undergoing
a
first
visit
at
University
center.
Two
multiple
regression
models
(1
for
males,
1
females)
built
with
BOP%
dependent
variable
(i.e.,
age;
smoking
status;
daily
cigarette
consumption;
history
diabetes
diagnosis;
number
teeth
present;
proportion
sites
PD
≥
5
mm
around
teeth)
independent
variables.
Results
In
males
(
n
=
212),
5.9%
lower
smokers
compared
non‐smokers
p
0.021).
females
389),
increased
1.6%
each
10‐year
increase
age
0.046).
showed
strongly
significant,
positive
irrespective
biological
sex
<
0.001).
Conclusion
SD
manifested
sex‐dependent
diversity
expressed
BOP%.
While
determined
only
aging
associated
females.
Plain
Language
Summary
Gingival
upon
mechanical
stimulation
bottom
gingival
sulcus/pocket
probe
(bleeding
[BOP])
is
suggestive
presence
an
inflammatory
infiltrate
induced
dental
plaque
tissue.
dentition
has
diagnostic
relevance,
being
one
main
parameters
discriminate
health
disease.
Also,
informs
probability
patient
either
develop
destructive
form
disease
periodontitis)
or
manifest
periodontitis
progression.
Based
documented
influence
incidence,
traits,
and/or
progression
rate
several
diseases,
which
goes
under
name
(SD),
effect
investigated
relation
that
previously
cohort
heterogeneous
conditions
their
visit.
Interestingly,
findings
may
find
potential
applications
personalized
medicine
inspire
future
studies
this
field.
Язык: Английский
Broadening the Healthy Aging Paradigm: Inclusion of Gestation, Development, and Reproductive Health
Advanced Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
The
prevailing
focus
of
lifespan
health
research
has
predominantly
centered
on
"healthy
aging".
This
oversight
may
hinder
the
understanding
across
lifespan,
as
disorders
in
earlier
stages
can
substantially
impact
overall
and
longevity.
Aging,
conceptually,
begins
at
gestation.
trajectory
an
individual's
is
influenced
from
earliest
life,
where
adverse
conditions
set
a
foundation
for
lifelong
challenges.
For
example,
suboptimal
during
gestation
leading
to
premature
birth
predispose
individuals
various
issues
later
life.
Additionally,
precocious
puberty
defined
onset
sexual
maturity
before
eight
years
age
or
early
menopause-occurring
50
requires
medical
intervention
indicative
atypical
aging
processes.
To
address
these
critical
gaps
research,
expansion
lexicons
categorizations
advocated
include
gestation,"
development,"
reproduction"
alongside
aging."
broader
terminology
will
enable
more
comprehensive
investigation
all
life
stages.
An
integrative
approach
underscores
interconnectedness
continuous
nature
aging,
advocating
seamless
continuum
interventions
through
late
adulthood.
Язык: Английский
Sex hormones and diseases of the nervous system
Brain medicine :,
Год журнала:
2025,
Номер
unknown, С. 1 - 10
Опубликована: Фев. 18, 2025
The
influence
of
gonadal
hormones
on
neurological
health
and
disease
is
a
rapidly
developing
domain
in
fundamental
clinical
neuroscience.
Sex
hormones,
directly
or
via
their
neurosteroid
metabolites,
impact
monoaminergic,
cholinergic,
peptidergic
neurotransmission
play
essential
roles
shaping
brain
organization
function
under
normal
pathological
conditions.
expression
various
disorders
may
be
modified
by
hormonal
fluctuations
related
to
the
menstrual
cycle,
pregnancy,
menopause,
oral
contraceptive
use.
Understanding
these
interactions
could
lead
targeted
antihormonal
therapies
for
diverse
conditions,
including
but
not
limited
catamenial
epilepsy,
Parkinson
disease,
acute
intermittent
porphyria.
Язык: Английский
Impact of DNA‐Methylation Age Acceleration on Long‐Term Mortality Among US Adults With Cardiovascular‐Kidney‐Metabolic Syndrome
Journal of the American Heart Association,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Background
The
association
between
DNA
methylation
age
acceleration
(DNAmAA)
and
cardiovascular‐kidney‐metabolic
(CKM)
syndrome
stages
long‐term
mortality
in
the
population
with
CKM
remains
unclear.
Methods
Results
This
cohort
study
included
1889
participants
from
National
Health
Nutrition
Examination
Survey
(1999–2002)
data.
DNAmAA
was
calculated
as
residuals
regression
of
on
chronological
age.
primary
outcome
all‐cause
mortality,
cardiovascular
noncardiovascular
secondary
outcomes.
Proportional
odds
models
assessed
associations
DNAmAAs
stages,
Cox
proportional
hazards
estimated
mortality.
Significant
were
found
advanced
particularly
for
GrimAge2Mort
(GrimAA)
(odds
ratio
[OR],
1.547
[95%
CI,
1.316–1.819]).
Over
an
average
follow‐up
14
years,
1015
deaths
occurred.
Each
5‐unit
increase
GrimAA
associated
a
50%
(95%
1.39–1.63),
77%
1.46–2.15),
42%
1.27–1.59).
With
lowest
tertile
reference,
highest
showed
hazard
ratios
1.95
1.56–2.45)
3.06
2.13–4.40)
1.65
1.20–2.29)
Mediation
analysis
indicated
that
mediates
various
exposures
(including
physical
activity,
Healthy
Eating
Index‐2015
score,
hemoglobin
A1c,
etc.)
Conclusions
may
serve
valuable
biomarker
assessing
risk
individuals
syndrome,
thereby
informing
personalized
management
strategies.
Язык: Английский
Oral Mycobiome Alterations in Postmenopausal Women: Links to Inflammation, Xerostomia, and Systemic Health
Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2569 - 2569
Опубликована: Ноя. 9, 2024
The
oral
mycobiome
plays
a
critical
role
in
maintaining
and
systemic
health,
with
its
composition
function
influenced
by
various
physiological
environmental
factors.
This
descriptive
review
explores
the
changes
among
postmenopausal
women,
examining
how
aging
associated
inflammatory
processes
contribute
to
these
alterations.
These
are
linked
an
increased
prevalence
of
xerostomia,
dysbiosis,
inflammation,
which
can
negatively
impact
both
health.
We
discuss
hormonal
fluctuations
immune
senescence
on
fungal
diversity
abundance,
highlighting
key
species
implicated
diseases.
also
examines
conditions
medications,
common
further
exacerbating
Lastly,
it
highlights
need
for
future
research
better
understand
interactions
develop
targeted
therapeutic
strategies.
current
literature
indicates
significant
association
between
menopausal
status,
age-related
shifts,
responses,
suggesting
potential
pathways
intervention.
Язык: Английский
Leukocyte telomere length decreased the risk of mortality in patients with alcohol-associated liver disease
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 12, 2024
Background
It
is
necessary
to
find
latent
indicators
predict
the
survival
of
alcohol-associated
liver
disease
(ALD)
patients.
Leukocyte
telomere
length
(LTL)
was
regarded
as
an
indicator
prognosis
in
several
diseases.
However,
relationships
between
LTL
and
well
cause-specific
mortality
ALD
patients
were
still
unknown.
Objective
This
study
aimed
at
exploring
underlying
link
risk
with
ALD.
Methods
The
data
gathered
from
National
Health
Nutrition
Examination
Survey
(NHANES)
1999–2002.
connection
assessed
by
Cox
regression
models
stratified
analyses.
non-linear
relationship
explored
restricted
cubic
spline
(RCS)
analysis.
Sensitivity
analyses
used
evaluate
robustness
our
findings.
Results
a
negative
factor
for
all-cause
(all
p
-value
<
0.05).
cardiovascular
(CVD)-related
death
decreased
Q3
(
0.001)
Q4
levels
compared
Q1
group.
Shorter
resulted
higher
cancer-caused
=
0.03)
Q2
Longer
improved
especially
elder
trend
or
men
0.001).
Moreover,
there
L-shaped
correlations
non-linearity
0.02),
cancer-related
Four
sensitivity
proved
Conclusion
Our
research
found
that
longer
CVD
mortality.
older
than
65
years
men.
might
be
useful
biomarker
among
More
prospective
studies
are
needed
assess
relevance
explore
mechanisms
them.
Язык: Английский