Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach
Amisha Bisht,
Anita Nayal,
Disha Tewari
и другие.
Biogerontology,
Год журнала:
2025,
Номер
26(2)
Опубликована: Фев. 5, 2025
Язык: Английский
Morphological, Molecular and Pathological Characterization of Phytophthora pseudocryptogea Associated with Rosmarinus officinalis Dieback in Tuscany, Central Italy
Microorganisms,
Год журнала:
2025,
Номер
13(3), С. 567 - 567
Опубликована: Март 3, 2025
A
severe
dieback
of
rosemary
(Rosmarinus
officinalis
L.)
plants
was
observed
in
a
medicinal/culinary
herb
plantation
Casole
d’Elsa,
Siena,
central
Italy.
Symptoms
included
stunted
growth,
crown
desiccation,
root
rot,
collar
rot
and
internal
tissue
necrosis,
strongly
indicative
Phytophthora
syndrome.
Morphological
molecular
identification
(ITS
Cox1
sequencing)
strains
isolated
from
symptomatic
stems,
roots
soil
revealed
the
occurrence
two
species:
pseudocryptogea,
which
constituted
94%
isolates
obtained
stem,
apparatus
rhizosphere;
megasperma,
not
recovered
plant
organs
or
tissue,
being
exclusively
rhizosphere
samples
at
low
isolation
rate
(6%).
The
pathogenicity
assessed
by
inoculating
eighteen-month-old
R.
infestation
trial.
Plants
inoculated
with
P.
pseudocryptogea
died
10
days
after
artificial
inoculation.
subsequently
re-isolated
inoculated,
plants,
thus
fulfilling
Koch’s
postulates.
megasperma
were
good
vegetative
condition
did
show
any
visible
symptoms,
suggesting
to
be
nonpathogenic.
Artificial
inoculation
tests
confirmed
aetiological
agent
responsible
for
death
under
study.
This
is
first
report
root,
caused
on
There
evidence
that
poorly
drained
soils
climate
constraints
facilitate
spread
this
oomycete.
These
findings
highlight
critical
role
nursery
trade
introduction
species
agroecosystems
emphasize
need
more
stringent
control
measures.
Язык: Английский
Discovering potent GSK3β inhibitors in Rosmarinus officinalis L. for Alzheimer’s disease using homology modeling, molecular docking, MD simulation
Amisha Bisht,
Anita Nayal,
Disha Tewari
и другие.
Network Modeling Analysis in Health Informatics and Bioinformatics,
Год журнала:
2025,
Номер
14(1)
Опубликована: Март 25, 2025
Язык: Английский
From Tea to Functional Foods: Exploring Caryopteris mongolica Bunge for Anti-Rheumatoid Arthritis and Unraveling Its Potential Mechanisms
Nutrients,
Год журнала:
2024,
Номер
16(24), С. 4311 - 4311
Опубликована: Дек. 13, 2024
Background:
Caryopteris
mongolica
Bunge
(CM)
shows
promising
potential
for
managing
rheumatoid
arthritis
(RA)
and
digestive
disorders,
attributed
to
its
rich
content
of
bioactive
compounds
such
as
polyphenols
flavonoids.
Despite
common
use
in
herbal
tea,
the
specific
mechanisms
underlying
CM’s
anti-inflammatory
joint-protective
effects
remain
unclear,
limiting
development
a
functional
food.
This
study
investigated
aqueous
CM
extract
on
RA
collagen-induced
(CIA)
rats
explored
mechanisms.
Methods:
Forty-eight
female
Sprague-Dawley
were
randomly
assigned
six
groups
(n
=
8):
normal
control,
CIA
model,
methotrexate
(MTX),
high-,
middle-,
low-dose
groups.
Anti-inflammatory
evaluated
using
biochemical
histological
analyses.
To
elucidate
mechanisms,
we
applied
metabolomics,
network
pharmacology,
transcriptomics
approaches.
Results:
The
results
demonstrated
that
effectively
suppressed
synovial
inflammation
rats,
reducing
joint
degradation.
mediated
through
TNF
signaling
pathway,
modulating
glycerophospholipid
amino
acid
metabolism,
including
reduced
levels
tryptophan,
LysoPC,
asparagine.
Molecular
docking
identified
scutellarin
apigenin
key
compounds.
Additionally,
immunofluorescence
analysis
revealed
therapeutic
via
inhibition
suppression
M1
macrophage
polarization.
Conclusions:
These
findings
highlight
support
food
or
pharmaceutical
product.
Язык: Английский