Extracellular Vesicles as Epigenetic Regulators of Redox Homeostasis: A Systematic Review and Meta-Analysis DOI Creative Commons
Cristina Mas‐Bargues,

Javier Huete-Acevedo,

Marta Arnal-Forné

и другие.

Antioxidants, Год журнала: 2025, Номер 14(5), С. 532 - 532

Опубликована: Апрель 29, 2025

Extracellular vesicles (EVs) are emerging as key regulators of cellular communication, with increasing evidence supporting their role in oxidative stress (OS) modulation. In particular, the miRNA cargo EVs plays a crucial mitigating OS and promoting redox balance through both direct antioxidant effects epigenetic regulation. This study aimed to evaluate impact on markers, influenced by miRNA-mediated potential modifications target cells. A systematic literature search was conducted following Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA) guidelines identify studies reporting parameters. meta-analysis performed biomarkers, including reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA). The heterogeneity EV isolation characterization techniques also analyzed. included demonstrated that exert significant reducing ROS levels, SOD activity GSH lowering MDA levels. These were largely attributed EV-miRNAs, which induce modulate redox-related signaling pathways. However, variability methods approaches highlights need standardization improve data comparability. Despite therapeutic potential, this research remains barrier translation. Moreover, further exploration mechanisms is essential fully harness benefits OS-related diseases.

Язык: Английский

Associations of epigenetic aging and COVID- 19: A 3-year longitudinal study DOI Creative Commons
G. Farkas,

Zahira El Mahdaouy,

Gergely Babszky

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Abstract Aging and COVID- 19 are known to influence DNA methylation, potentially affecting the rate of aging risk disease. The physiological functions 54 volunteers—including maximal oxygen uptake (VO₂ max), grip strength, vertical jump—were assessed just before pandemic again 3 years later. Of these volunteers, 27 had contracted 19. Eight epigenetic clocks were used assess during 3-year period: DNAmAge showed accelerated aging, five slowed (DNAmAgeSkinBlood, DNAmAgeHannum, DNAmFitAge, PhenoAge, DNAmTL). When we considered only females, observed a stronger effect in increase acceleration, while case SkinBloodClock, DNAmTL. methylation promoter region H1 FNT genes, which encodes testis-specific histone family member N (H1fnt) plays crucial role spermatogenesis decreased most significantly. In contrast, CSTL1, Cystatin-like 1, significant increase. We found that having study period significantly increased progress by DNAmGrimAge, DNAmGrimAge2, DNAmFitAge ( p = 0.024, 0.047, 0.032, respectively, after adjusted analysis for baseline variables). data suggest may have mild long-term on aging.

Язык: Английский

Процитировано

0
Associations of exposure to volatile organic compounds with biological aging: a cross-sectional study DOI Creative Commons
X M Shi,

YiNi Wang,

Fei Yang

и другие.

BMC Public Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 22, 2025

Язык: Английский

Процитировано

0
Extracellular Vesicles as Epigenetic Regulators of Redox Homeostasis: A Systematic Review and Meta-Analysis DOI Creative Commons
Cristina Mas‐Bargues,

Javier Huete-Acevedo,

Marta Arnal-Forné

и другие.

Antioxidants, Год журнала: 2025, Номер 14(5), С. 532 - 532

Опубликована: Апрель 29, 2025

Extracellular vesicles (EVs) are emerging as key regulators of cellular communication, with increasing evidence supporting their role in oxidative stress (OS) modulation. In particular, the miRNA cargo EVs plays a crucial mitigating OS and promoting redox balance through both direct antioxidant effects epigenetic regulation. This study aimed to evaluate impact on markers, influenced by miRNA-mediated potential modifications target cells. A systematic literature search was conducted following Preferred Reporting Items for Systematic Reviews Meta-Analysis (PRISMA) guidelines identify studies reporting parameters. meta-analysis performed biomarkers, including reactive oxygen species (ROS), superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA). The heterogeneity EV isolation characterization techniques also analyzed. included demonstrated that exert significant reducing ROS levels, SOD activity GSH lowering MDA levels. These were largely attributed EV-miRNAs, which induce modulate redox-related signaling pathways. However, variability methods approaches highlights need standardization improve data comparability. Despite therapeutic potential, this research remains barrier translation. Moreover, further exploration mechanisms is essential fully harness benefits OS-related diseases.

Язык: Английский

Процитировано

0