Associations of epigenetic aging and COVID- 19: A 3-year longitudinal study
G. Farkas,
Zahira El Mahdaouy,
Gergely Babszky
и другие.
GeroScience,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Aging
and
COVID-
19
are
known
to
influence
DNA
methylation,
potentially
affecting
the
rate
of
aging
risk
disease.
The
physiological
functions
54
volunteers—including
maximal
oxygen
uptake
(VO₂
max),
grip
strength,
vertical
jump—were
assessed
just
before
pandemic
again
3
years
later.
Of
these
volunteers,
27
had
contracted
19.
Eight
epigenetic
clocks
were
used
assess
during
3-year
period:
DNAmAge
showed
accelerated
aging,
five
slowed
(DNAmAgeSkinBlood,
DNAmAgeHannum,
DNAmFitAge,
PhenoAge,
DNAmTL).
When
we
considered
only
females,
observed
a
stronger
effect
in
increase
acceleration,
while
case
SkinBloodClock,
DNAmTL.
methylation
promoter
region
H1
FNT
genes,
which
encodes
testis-specific
histone
family
member
N
(H1fnt)
plays
crucial
role
spermatogenesis
decreased
most
significantly.
In
contrast,
CSTL1,
Cystatin-like
1,
significant
increase.
We
found
that
having
study
period
significantly
increased
progress
by
DNAmGrimAge,
DNAmGrimAge2,
DNAmFitAge
(
p
=
0.024,
0.047,
0.032,
respectively,
after
adjusted
analysis
for
baseline
variables).
data
suggest
may
have
mild
long-term
on
aging.
Язык: Английский
Associations of exposure to volatile organic compounds with biological aging: a cross-sectional study
BMC Public Health,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 22, 2025
Язык: Английский
Extracellular Vesicles as Epigenetic Regulators of Redox Homeostasis: A Systematic Review and Meta-Analysis
Antioxidants,
Год журнала:
2025,
Номер
14(5), С. 532 - 532
Опубликована: Апрель 29, 2025
Extracellular
vesicles
(EVs)
are
emerging
as
key
regulators
of
cellular
communication,
with
increasing
evidence
supporting
their
role
in
oxidative
stress
(OS)
modulation.
In
particular,
the
miRNA
cargo
EVs
plays
a
crucial
mitigating
OS
and
promoting
redox
balance
through
both
direct
antioxidant
effects
epigenetic
regulation.
This
study
aimed
to
evaluate
impact
on
markers,
influenced
by
miRNA-mediated
potential
modifications
target
cells.
A
systematic
literature
search
was
conducted
following
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analysis
(PRISMA)
guidelines
identify
studies
reporting
parameters.
meta-analysis
performed
biomarkers,
including
reactive
oxygen
species
(ROS),
superoxide
dismutase
(SOD),
glutathione
(GSH),
malondialdehyde
(MDA).
The
heterogeneity
EV
isolation
characterization
techniques
also
analyzed.
included
demonstrated
that
exert
significant
reducing
ROS
levels,
SOD
activity
GSH
lowering
MDA
levels.
These
were
largely
attributed
EV-miRNAs,
which
induce
modulate
redox-related
signaling
pathways.
However,
variability
methods
approaches
highlights
need
standardization
improve
data
comparability.
Despite
therapeutic
potential,
this
research
remains
barrier
translation.
Moreover,
further
exploration
mechanisms
is
essential
fully
harness
benefits
OS-related
diseases.
Язык: Английский