Toxicology Research,
Год журнала:
2024,
Номер
13(6)
Опубликована: Ноя. 5, 2024
Abstract
Background
Rapid
industrialization
globally
has
led
to
a
notable
increase
in
the
production
and
utilization
of
metals,
including
cadmium
(Cd),
consequently
escalating
global
metal
pollution
worldwide.
Cd,
characterized
as
persistent
environmental
contaminant,
poses
significant
health
risks,
particularly
impacting
human
health,
notably
functionality
kidneys.
The
profound
effects
Cd
stem
primarily
from
its
limited
excretion
capabilities
extended
half-life
within
body.
Mechanisms
underlying
toxicity
encompass
generating
reactive
oxygen
species
(ROS),
disrupting
calcium-signaling
pathways
impairing
cellular
antioxidant
defense
mechanisms.
This
review
focuses
on
protective
various
herbal
active
ingredients
against
Cd-induced
nephrotoxicity.
Aim
study
aims
investigate
mechanisms
action
ingredients,
ant-oxidative,
anti-inflammatory
anti-apoptotic
pathways,
elucidate
potential
therapeutic
strategies
for
reducing
nephrotoxicity
caused
by
exposure.
Methods
A
comprehensive
search
scientific
databases,
Web
Science,
PubMed,
Scopus
Google
Scholar,
used
relevant
keywords
identify
studies
published
up
October
2024.
Results
Research
illustrates
that
protect
oxidative
stress,
enhancing
enzyme
activity,
inhibiting
inflammation,
preventing
apoptosis,
alleviating
endoplasmic
reticulum
(ER)
autophagy
improving
mitochondrial
function
kidney.
Conclusion
present
indicates
an
extensive
understanding
holds
promise
development
innovative
approaches
safeguard
integrity
detrimental
Journal of Chemistry,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Food
contamination
with
heavy
metals
accumulated
in
agricultural
soils
due
to
extensive
fertilizer
and
pesticide
use
poses
a
significant
threat
human
health.
To
address
this
global
concern,
measures
must
be
taken
evaluate
the
risk
of
metal
food
medicinal
plants.
Recently,
pigeon
pea
(guandul,
Cajanus
cajan
),
legume
commonly
found
Panamá,
has
been
reported
grow
contaminated
absorb
them.
Therefore,
study
aimed
assess
capacity
C.
plants
bioaccumulate
metals.
was
cultivated
Cd,
Cr,
Zn,
Cu,
Mn
bioaccumulation
its
impact
on
these
While
initial
responses
were
minimal,
prolonged
exposure
revealed
impacts,
such
as
positively
influencing
chlorophyll
production,
whereas
Cd
adversely
affected
synthesis
plant
height
viability.
exhibited
varying
efficiencies
soil
removal,
notably
extracting
Mn.
Translocation
factors
indicated
effective
movement
shoots,
while
primarily
roots.
These
findings
highlight
potential
for
phytostabilization
phytoextraction
metal‐contaminated
environments.
Our
suggest
that
is
viable
crop
cultivation
moderately
soils.
Future
research
should
optimize
practices
maximize
phytoremediation
deepen
understanding
uptake
mechanisms
species,
processes
are
crucial
sustainable
agriculture
environmental
management.
Toxicology Research,
Год журнала:
2024,
Номер
13(6)
Опубликована: Ноя. 5, 2024
Abstract
Background
Rapid
industrialization
globally
has
led
to
a
notable
increase
in
the
production
and
utilization
of
metals,
including
cadmium
(Cd),
consequently
escalating
global
metal
pollution
worldwide.
Cd,
characterized
as
persistent
environmental
contaminant,
poses
significant
health
risks,
particularly
impacting
human
health,
notably
functionality
kidneys.
The
profound
effects
Cd
stem
primarily
from
its
limited
excretion
capabilities
extended
half-life
within
body.
Mechanisms
underlying
toxicity
encompass
generating
reactive
oxygen
species
(ROS),
disrupting
calcium-signaling
pathways
impairing
cellular
antioxidant
defense
mechanisms.
This
review
focuses
on
protective
various
herbal
active
ingredients
against
Cd-induced
nephrotoxicity.
Aim
study
aims
investigate
mechanisms
action
ingredients,
ant-oxidative,
anti-inflammatory
anti-apoptotic
pathways,
elucidate
potential
therapeutic
strategies
for
reducing
nephrotoxicity
caused
by
exposure.
Methods
A
comprehensive
search
scientific
databases,
Web
Science,
PubMed,
Scopus
Google
Scholar,
used
relevant
keywords
identify
studies
published
up
October
2024.
Results
Research
illustrates
that
protect
oxidative
stress,
enhancing
enzyme
activity,
inhibiting
inflammation,
preventing
apoptosis,
alleviating
endoplasmic
reticulum
(ER)
autophagy
improving
mitochondrial
function
kidney.
Conclusion
present
indicates
an
extensive
understanding
holds
promise
development
innovative
approaches
safeguard
integrity
detrimental
