Metformin in Antiviral Therapy: Evidence and Perspectives
Viruses,
Год журнала:
2024,
Номер
16(12), С. 1938 - 1938
Опубликована: Дек. 18, 2024
Metformin,
a
widely
used
antidiabetic
medication,
has
emerged
as
promising
broad-spectrum
antiviral
agent
due
to
its
ability
modulate
cellular
pathways
essential
for
viral
replication.
By
activating
AMPK,
metformin
depletes
energy
reserves
that
viruses
rely
on,
effectively
limiting
the
replication
of
pathogens
such
influenza,
HIV,
SARS-CoV-2,
HBV,
and
HCV.
Its
role
in
inhibiting
mTOR
pathway,
crucial
protein
synthesis
reactivation,
is
particularly
significant
managing
infections
caused
by
CMV,
EBV.
Furthermore,
reduces
oxidative
stress
reactive
oxygen
species
(ROS),
which
are
critical
replicating
arboviruses
Zika
dengue.
The
drug
also
regulates
immune
responses,
differentiation,
inflammation,
disrupting
life
cycle
HPV
potentially
other
viruses.
These
diverse
mechanisms
suppress
replication,
enhance
system
functionality,
contribute
better
clinical
outcomes.
This
multifaceted
approach
highlights
metformin’s
potential
an
adjunctive
therapy
treating
wide
range
infections.
Язык: Английский
Comparative Study of Docking Tools for Evaluation of Potential Copper Metallodrugs and Their Interaction with TMPRSS2
Inorganics,
Год журнала:
2024,
Номер
12(11), С. 282 - 282
Опубликована: Окт. 30, 2024
COVID-19
has
caused
over
seven
million
deaths
globally
due
to
its
high
transmission
rate.
The
virus
responsible
for
the
disease
requires
a
transmembrane
protease
serine
type
II
(TMPRSS2-7MEQ)
infiltrate
host
cells
and
been
linked
several
cancers,
particularly
prostate
cancer.
To
investigate
potential
therapies,
series
of
Casiopeina-like
copper
complexes
containing
1,10-Phenanthroline
amino
acids
were
investigated
as
TMPRSS2
inhibitors.
molecular
structures
twelve
Phenanthroline
calculated,
their
global
reactivity
indices
analyzed
using
DFT
conceptual
methods.
Three
docking
algorithms
employed
identify
most
effective
inhibitors
by
examining
interactions
with
acid
residues
in
target
protein’s
catalytic
activity
triad
(Asp345,
His296,
Ser441).
All
are
docked
above
site,
blocking
interaction
substrates.
showed
better
than
Bipyridine
complexes,
likely
increased
hydrophobic
contacts.
Analogs’
cationic
nature
acids’
basic
side
chains
bring
them
near
active
site
interacting
Asp435.
top
this
study
contain
Ornithine,
Lysine,
Arginine,
making
promising
alternatives
researching
new
drugs
cancers
like
Язык: Английский