Involvement of muscarinic acetylcholine receptor-mediated cholinergic neurotransmission in TMS–EEG responses DOI Creative Commons
Yufei Song,

Pedro Caldana Gordon,

Olivier Roy

и другие.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2024, Номер 136, С. 111167 - 111167

Опубликована: Окт. 9, 2024

The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a valuable tool for investigating brain functions in health disease. However, the detailed neural mechanisms underlying TMS-EEG responses, including TMS-evoked EEG potentials (TEPs) TMS-induced oscillations (TIOs), remain largely unknown. Combining with pharmacological interventions provides unique opportunity to elucidate roles specific receptor-mediated neurotransmissions these responses. Here, we investigated involvement muscarinic acetylcholine receptor (mAChR)-mediated cholinergic neurotransmission responses by evaluating effects mAChR antagonists on TEPs TIOs twenty-four healthy participants using randomized, placebo-controlled crossover design. were measured before after administering single oral dose scopolamine (a non-selective antagonist), biperiden (an M1 or placebo, TMS targeting left medial prefrontal cortex (mPFC), angular gyrus (AG), supplementary motor area (SMA). results indicated that mAChR-mediated played role TEPs, but not TIOs, target-specific manner. Specifically, significantly increased amplitude local TEP component between approximately 40 63 ms post-stimulus when was applied SMA, mPFC AG. Biperiden produced similar less pronounced effect. Importantly, independent those sensory-evoked caused TMS-associated sensory stimulation. These findings expand our understanding physiology, providing insights its application physiological clinical research.

Язык: Английский

Neuroimaging of motor recovery after ischemic stroke − functional reorganization of motor network DOI Creative Commons

Pei Yu,

Ruoyu Dong,

Xiao Wang

и другие.

NeuroImage Clinical, Год журнала: 2024, Номер 43, С. 103636 - 103636

Опубликована: Янв. 1, 2024

The long-term motor outcome of acute stroke patients may be correlated to the reorganization brain network. Abundant neuroimaging studies contribute understand pathological changes and recovery networks after stroke. In this review, we summarized how current have increased understanding plasticity in post recovery. Firstly, discussed network over time during motor-activation resting states, as well overall functional integration trend These indicate that undergoes dynamic bilateral hemispheric reorganization, a towards randomization. second part, study progress application technology early predict post-stroke outcome. third discuss techniques commonly used methods provide direct or indirect visualization patterns neural mechanisms recovery, opening up new avenues for studying spontaneous treatment-induced

Язык: Английский

Процитировано

4
Bridging the gap to clinical use: A systematic review on TMS–EEG test-retest reliability DOI Creative Commons
Giacomo Bertazzoli, Elisa Dognini, Peter J. Fried

и другие.

Clinical Neurophysiology, Год журнала: 2025, Номер 171, С. 133 - 145

Опубликована: Янв. 24, 2025

Язык: Английский

Процитировано

0
Involvement of muscarinic acetylcholine receptor-mediated cholinergic neurotransmission in TMS–EEG responses DOI Creative Commons
Yufei Song,

Pedro Caldana Gordon,

Olivier Roy

и другие.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2024, Номер 136, С. 111167 - 111167

Опубликована: Окт. 9, 2024

The combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) is emerging as a valuable tool for investigating brain functions in health disease. However, the detailed neural mechanisms underlying TMS-EEG responses, including TMS-evoked EEG potentials (TEPs) TMS-induced oscillations (TIOs), remain largely unknown. Combining with pharmacological interventions provides unique opportunity to elucidate roles specific receptor-mediated neurotransmissions these responses. Here, we investigated involvement muscarinic acetylcholine receptor (mAChR)-mediated cholinergic neurotransmission responses by evaluating effects mAChR antagonists on TEPs TIOs twenty-four healthy participants using randomized, placebo-controlled crossover design. were measured before after administering single oral dose scopolamine (a non-selective antagonist), biperiden (an M1 or placebo, TMS targeting left medial prefrontal cortex (mPFC), angular gyrus (AG), supplementary motor area (SMA). results indicated that mAChR-mediated played role TEPs, but not TIOs, target-specific manner. Specifically, significantly increased amplitude local TEP component between approximately 40 63 ms post-stimulus when was applied SMA, mPFC AG. Biperiden produced similar less pronounced effect. Importantly, independent those sensory-evoked caused TMS-associated sensory stimulation. These findings expand our understanding physiology, providing insights its application physiological clinical research.

Язык: Английский

Процитировано

1