Pan-cancer analysis unveils the role and mechanisms of neddylation modifications in tumorigenesis

Medical Oncology, Год журнала: 2025, Номер 42(4)

Опубликована: Март 19, 2025

Язык: Английский

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Unraveling the Mechanisms of Shaoyang Shenggu Decoction in Treating Knee Osteoarthritis through Mass Spectrometry and Bioinformatics

Journal of Ethnopharmacology, Год журнала: 2025, Номер unknown, С. 119835 - 119835

Опубликована: Апрель 1, 2025

Язык: Английский

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FOXO1 mediates miR-99a-5p/E2F7 to restrain breast cancer cell proliferation and induce apoptosis

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 22, 2025

Язык: Английский

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Integrated analysis reveals the regulatory mechanism of the neddylation inhibitor MLN4924 on the metabolic dysregulation in rabbit granulosa cells

BMC Genomics, Год журнала: 2024, Номер 25(1)

Опубликована: Март 6, 2024

Abstract Background Neddylation, an important post-translational modification (PTM) of proteins, plays a crucial role in follicular development. MLN4924 is small-molecule inhibitor the neddylation-activating enzyme (NAE) that regulates various biological processes. However, regulatory mechanisms neddylation rabbit ovarian cells have not been emphasized. Here, transcriptome and metabolome profiles granulosa (GCs) treated with were utilized to identify differentially expressed genes, followed by pathway analysis precisely define altered metabolisms. Results The results showed 563 upregulated 910 downregulated genes (DEGs) mainly enriched pathways related cancer, cell cycle, PI3K-AKT, progesterone-mediated oocyte maturation, PPAR signaling pathway. Furthermore, we characterized inhibits PPAR-mediated lipid metabolism, disrupts cycle promoting apoptosis proliferation GCs. Importantly, found reduction several metabolites GCs, including glycerophosphocholine, arachidic acid, palmitic which was consistent deregulation pathways. increased included 6-Deoxy-6-sulfo-D-glucono-1,5-lactone N-Acetyl-D-glucosaminyldiphosphodolichol. Combined data analyses, identified strongly correlate metabolic dysregulation, particularly those glucose metabolism. Therefore, inhibition may disrupt energy metabolism Conclusions These provide foundation for in-depth research into molecular mechanism ovary

Язык: Английский

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New insights of LncRNAs fingerprints in breast cancer progression: Tumorigenesis, drug resistance, and therapeutic opportunities

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 287, С. 138589 - 138589

Опубликована: Дек. 9, 2024

Breast cancer (BC) is one of the common female cancers and it characterized by considerable problems regarding its development therapy. Long non-coding RNAs (lncRNAs) have been identified as significant modulators in BC development, especially, tumorigenicity chemoresistance. We therefore endeavor to present an up-to-date understanding lncRNAs their impact on progression treatment, concerning molecular processes, treatment options, use a therapeutic opportunity. LncRNAs are novel regulators genes that cause resistance directly functioning both coding patients, but little known about mechanisms actions. Thus, additional study required deeper modes action possible roles disease. This aims investigate functions BC, with particular attention role tumorigenesis, drug mechanisms, targets. will help identify targets improve effectiveness treatment.

Язык: Английский

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Propofol‐induced LINC01133 inhibits the progression of colorectal cancer via miR‐186‐5p/NR3C2 axis

Environmental Toxicology, Год журнала: 2023, Номер 39(4), С. 2265 - 2284

Опубликована: Дек. 26, 2023

Abstract Colorectal cancer (CRC) is a formidable threat to human well‐being, characterized by largely enigmatic occurrence and progression mechanism. A growing body of literature has underscored the potential influence propofol, frequently administered anesthetic, on clinical outcomes in malignant tumor patients. However, precise molecular mechanisms underlying impact propofol CRC have yet be fully elucidated. This study reveals notable upregulation LINC01133 expression cells subsequent treatment, which mediated FOXO1. Subsequently, series experiments were conducted elucidate role propofol‐induced development. Our uncovers that exerts substantial inhibitory effect proliferation, migration, invasion cells. Further investigation revealed can attenuate invasion, migration cell lines through miR‐186‐5p/NR3C2 axis. Results from vivo unequivocally demonstrated significant reduction growth rate subcutaneous implant tumors upon overexpression These findings posit induces expression, leading inhibition progression. revelation offers novel perspective propofol's antitumor properties underscores as promising therapeutic target for CRC.

Язык: Английский

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Deciphering the roles of neddylation modification in hepatocellular carcinoma: Molecular mechanisms and targeted therapeutics

Genes & Diseases, Год журнала: 2024, Номер unknown, С. 101483 - 101483

Опубликована: Дек. 1, 2024

Язык: Английский

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