Targeting ferroptosis: a promising strategy to overcome drug resistance in breast cancer DOI Creative Commons
Cuixin Peng, Yanning Chen,

Min‐Li Jiang

и другие.

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Дек. 20, 2024

Breast cancer is one of the most prevalent malignancies affecting women worldwide, with its incidence increasingly observed in younger populations. In recent years, drug resistance has emerged as a significant challenge treatment breast cancer, making it central focus contemporary research aimed at identifying strategies to overcome this issue. Growing evidence indicates that inducing ferroptosis through various mechanisms, particularly by inhibiting System Xc

Язык: Английский

Theoretical Framework and Emerging Challenges of Lipid Metabolism in Cancer DOI Creative Commons
Qiuying Gu, Yuan Wang, Ping Yi

и другие.

Seminars in Cancer Biology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Elevated lipid metabolism is one of hallmarks malignant tumors. Lipids not only serve as essential structural components biological membranes but also provide energy and substrates for the proliferation cancer cells tumor growth. Cancer meet their needs by coordinating processes absorption, synthesis, transport, storage, catabolism. As research in this area continues to deepen, numerous new discoveries have emerged, making it crucial scientists stay informed about developments metabolism. In review, we first discuss relevant concepts theories or assumptions that help us understand -based therapies. We then systematically summarize latest advancements including mechanisms, novel targets, up-to-date pre-clinical clinical investigations anti-cancer treatment with targeted drugs. Finally, emphasize emerging directions therapeutic strategies, future prospective challenges. This review aims insights guidance field

Язык: Английский

Процитировано

8
Apatinib combined with paclitaxel suppresses synergistically TNBC progression through enhancing ferroptosis susceptibility regulated SLC7A11/GPX4/ACSL4 axis DOI
Xiaoxia Ma, Di Cao, Yan Zhang

и другие.

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111760 - 111760

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1
Absence of Cysteine and Iron Chelation Induces Ferroptosis in Triple-Negative Breast Cancer Cells DOI Creative Commons

Manvi Agarwal Neeraj,

Junjeong Choi

Breast Cancer Basic and Clinical Research, Год журнала: 2025, Номер 19

Опубликована: Янв. 1, 2025

Background: Ferroptosis is a recently studied form of programmed cell death characterized by lipid peroxides accumulation in the cells. This process occurs when cell’s antioxidant capacity disturbed resulting inability to detoxify toxic peroxides. Two major components that regulate ferroptosis are cysteine and iron. Objective: study aimed determine effect deficiency iron chelation on triple-negative breast cancer (TNBC) lipid-enriched microenvironment. Design: The has laboratory-based experimental design. used MDA-MB-231 line various vitro culture systems investigate research question. Methods: For first part study, we subjected cells grow cysteine-absent adipocyte-conditioned media. In second half, treated with chelator, deferoxamine. BODIPY imaging western blot were carried out observe under 2 conditions. Results: results showed absence conditioned media was able reduce formation droplets, which increased greater access free fatty acids undergo oxidation, therefore inducing ferroptosis. On contrary, deferoxamine along erastin (ferroptosis-inducing drug), an increase content observed, later Conclusion: Our show alternative function deferoxamine, one regulating droplets other ferroptosis, although inhibitor same, respectively.

Язык: Английский

Процитировано

0
Broadening horizons: research on ferroptosis in lung cancer and its potential therapeutic targets DOI Creative Commons
Guangpeng Gao, Xindi Zhang

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 23, 2025

Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.

Язык: Английский

Процитировано

0
Current Status and Future Directions of Ferroptosis Research in Breast Cancer: Bibliometric Analysis DOI Creative Commons
Jia‐Yuan Luo, Yu-Long Deng,

Sharon Lu

и другие.

Interactive Journal of Medical Research, Год журнала: 2025, Номер 14, С. e66286 - e66286

Опубликована: Фев. 26, 2025

Background Ferroptosis, as a novel modality of cell death, holds significant potential in elucidating the pathogenesis and advancing therapeutic strategies for breast cancer. Objective This study aims to comprehensively analyze current ferroptosis research future trends, guiding cancer advancements innovative treatment strategies. Methods used R package Bibliometrix (Department Economic Statistical Sciences at University Naples Federico II), VOSviewer (Centre Science Technology Studies Leiden University), CiteSpace (Drexel University’s College Information Technology), conduct bibliometric analysis 387 papers on from Web Core Collection. The covers authors, institutions, journals, countries or regions, publication volumes, citations, keywords. Results number publications related this field has surged annually, with China United States collaborating closely leading output. Sun Yat-sen stands out among while journal Frontiers Oncology author Efferth T contribute significantly field. Highly cited within domain primarily focus induction ferroptosis, protein regulation, comparisons other modes providing foundation treatment. Keyword highlights maturity glutathione peroxidase 4-related research, subtypes emerging motor themes tumor microenvironment, immunotherapy, prognostic models identified basic themes. Furthermore, application nanoparticles serves an additional complement Conclusions status focuses exploration relevant theoretical mechanisms, whereas trends mechanisms emphasize investigation strategies, particularly clinical immunotherapy microenvironment. Nanotherapy demonstrated domain. Future directions should deepen accelerate translation findings provide new insights innovation development

Язык: Английский

Процитировано

0
Orphan Nuclear Receptor 4A1 (NR4A1) and NR4A2 are Endogenous Regulators of CD71 and Their Ligands Induce Ferroptosis in Breast Cancer DOI
Stephen Safe, Arafat Rahman Oany,

Srijana Upadhyay

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Ferroptosis is an iron-dependent cell death pathway that involves multiple genes including the transferrin receptor (TFRC/CD71), glutathione peroxidase 4 (GPX4) and SLC7A11. This study based on hypothesis orphan nuclear 4A1 (NR4A1) NR4A2 maintain low levels of ferroptosis in triple negative breast cancer (TNBC) cells bis-indole derived (CDIM) compounds act as NR4A1/2 ligands induce by enhancing CD71 expression. 1,1-Bis(3'-indolyl)-1-(3,5-disubstitutedphenyl)methane (DIM-3,5) analogs were investigated for their cytotoxicity effects NR4A1 regulated induction cytotoxicity, western blot RT-PCR. Several assays also determined enhanced lipoperoxidation, reactive oxygen species malondialdehyde formation TNBC cells. Knockdown NR4A1, NR4A2, Sp1 Sp4 was carried out RNA interference. Molecular mechanisms NR4A1/2-mediated regulation expression using CD71-luciferase promoter constructs, overexpression chromatin immunoprecipitation (ChIP) assays. Initial studies show DIM-3,5 inverse NR4A1/NR4A2 agonist downregulated pro-oncogenic responses/gene products both receptors induced ROS, lipoperoxide this accompanied indicators include decreased GPX4 SLC7A11 CD71. Induction CD71, important biomarker observed after treatment with analogs, knockdown or demonstrating coregulated receptors. Moreover, ChIP analysis indicated acted ligand-dependent cofactors Sp1/4-mediated a key NR4A1/2/Sp gene can be directly targeted agonists to

Язык: Английский

Процитировано

0
Role of ferroptosis in breast cancer: Molecular mechanisms and therapeutic interventions DOI
Wei Wang, Zihui Liu, Junjie Li

и другие.

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111869 - 111869

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Ferroptosis-related gene signature-based subtype identification of triple-negative breast cancer to prioritize treatment strategies DOI Creative Commons
Yongzhen Chen, Xiaoying Huang,

J Wang

и другие.

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Май 20, 2025

Purpose Ferroptosis, an iron-dependent form of regulated cell death (RCD), has been proven to affect the response antineoplastic therapies. However, little is known about role ferroptosis in chemotherapy and immune checkpoint inhibitor (ICI) therapy responses, as well molecular subtype identification triple-negative breast cancer (TNBC). Methods We performed unsupervised clustering stratify patients with TNBC Fudan University Shanghai Cancer Center (FUSCC) cohort into distinct ferroptosis-related subtypes according expression eight genes (FRGs): EMC2, FTH1, HMOX1, LPCAT3, NOX4, SOCS1, BAP1, ISCU. conducted Gene Ontology (GO) analysis gene set variation (GSVA) characterize phenotype enriched pathways TNBC. constructed FerrScore model identify most promising candidate compounds predict ICI benefits for Results identified two different overall survival (OS). Patients cluster 1 exhibited better OS, which had a “hot” tumor abundant infiltration higher checkpoints compared 2. screened everolimus drug high referring comprehensive factors including CMap score, experimental evidence, clinical trial status. Further, we confirmed that was potentially powerful metric anti-PD-L1, anti-PD-1, anti-PD-1 + CTLA-4 benefits. Conclusions Ferroptosis reprogrammed microenvironment (TME) classified subgroups significantly OS. screen TNBC, prioritized treatment strategies.

Язык: Английский

Процитировано

0
Penicilazaphilone C triggers ferroptosis in triple-negative breast cancer cells via the MDM2/p53/SLC7 A11/GPX4 pathway DOI Creative Commons
Hua Liang, Feng-Ying Huang, Wenhui Xie

и другие.

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Июнь 2, 2025

Penicilazaphilone C (PAC) is a novel azaphilone isolated by our research team. While known for its antitumor properties, the potential of PAC to trigger ferroptosis in triple-negative breast cancer (TNBC) cells remains unexplored. This study aims assess ferroptotic induction capability and elucidate underlying molecular mechanisms. Our results showed that treatment with demonstrated dose- time-dependent inhibition growth MDA-MB-231 MDA-MB-436 cells. Flow cytometry analysis lactate dehydrogenase assay revealed various forms cell death induced both lines. Specifically, flow analyzed 7-AAD-stained dead cells, markers, such as lipid peroxidation BODIPY-C11 Fe2+ ions, identified major type pathway PAC. Moreover, co-administration inhibitor Fer-1 notably mitigated PAC-induced death, further highlighting primary mechanism through which inhibits TNBC proliferation. Further exploration mechanisms unveiled modulated expression Mouse double minute 2 (MDM2), p53, SLC7A11, GPX4. In vivo experiments using nude mouse models implanted effectively suppressed tumor growth, increased levels ions single downregulated MDM2 expression, upregulated GPX4 expression. These suggest hinders proliferation modulating MDM2/p53/SLC7A11/GPX4 axis induce ferroptosis, positioning promising candidate therapy.

Язык: Английский

Процитировано

0
TFAP2A Promotes Cell Progression and Suppresses Ferroptosis in Lung Adenocarcinoma via Activating Transcription of CST1 DOI Open Access
Xinyu Luan,

Xuxing Peng,

Gang Hui

и другие.

Journal of Biochemical and Molecular Toxicology, Год журнала: 2024, Номер 39(1)

Опубликована: Дек. 18, 2024

ABSTRACT Lung adenocarcinoma (LUAD) is a common type of lung cancer with complicated pathological mechanism. Transcription Factor AP‐2 Alpha (TFAP2A) and Cysteine protease inhibitor 1 (CST1) are upregulated genes in LUAD samples, accordingly, we focused on clarifying the role TFAP2A/CST1 axis LUAD. Expression analysis was performed using real‐time quantitative polymerase chain reaction western blot. Cellular behaviors were detected by colony formation assay, EdU wound healing assay flow cytometry. Ferroptosis assessed oxidative indicators, Fe 2+ level related proteins. TFAP2A CST1 interaction analyzed via ChIP dual‐luciferase reporter assay. function vivo evaluated xenograft tumor overexpressed samples cells. Downregulation inhibited proliferation, migration but it promoted apoptosis ferroptosis interacted promoter to up‐regulate expression. regulated malignant cells targeting CST1. affected growth mediating All these data proved that contributed while suppressed

Язык: Английский

Процитировано

0