Regulation of metastatic organotropism
Trends in cancer,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Unveiling the role of cellular dormancy in cancer progression and recurrence
Current Opinion in Oncology,
Год журнала:
2024,
Номер
36(2), С. 74 - 81
Опубликована: Янв. 2, 2024
Purpose
of
review
Cellular
dormancy
is
a
major
contributor
to
cancer
progression
and
recurrence.
This
explores
recent
findings
on
the
molecular
mechanisms
implicated
in
investigates
potential
strategies
improve
therapeutic
interventions.
Recent
Research
reveals
complex
multifaceted
phenomenon.
Providing
latent
reservoir
tumor
cells
with
reduced
proliferation
enhanced
drug-tolerance,
dormant
emerge
from
clonally
diverse
population
after
therapy
or
at
metastatic
sites.
These
exhibit
distinct
transcriptional
epigenetic
profiles,
involving
downregulation
Myc
mechanistic
target
rapamycin
(mTOR)
pathways,
induction
autophagy.
Senescence
traits,
under
control
factors
such
as
p53,
also
contribute
significantly.
The
microenvironment
can
either
promote
prevent
establishment,
notably
through
involvement
T
NK
within
niche.
Strategies
combat
dormancy-related
relapse
include
direct
elimination
cells,
sustaining
prolong
survival,
awakening
re-sensitize
them
antiproliferative
drugs.
Summary
Improving
our
understanding
primary
secondary
sites
provides
valuable
insights
into
patient
care
prevention.
Язык: Английский
Awakening of Dormant Breast Cancer Cells in the Bone Marrow
Cancers,
Год журнала:
2023,
Номер
15(11), С. 3021 - 3021
Опубликована: Июнь 1, 2023
Up
to
40%
of
patients
with
breast
cancer
(BC)
have
metastatic
cells
in
the
bone
marrow
(BM)
at
initial
diagnosis
localized
disease.
Despite
definitive
systemic
adjuvant
therapy,
these
survive
BM
microenvironment,
enter
a
dormant
state
and
recur
stochastically
for
more
than
20
years.
Once
they
begin
proliferate,
recurrent
macrometastases
are
not
curable,
generally
succumb
their
Many
potential
mechanisms
initiating
recurrence
been
proposed,
but
no
predictive
data
generated.
This
manuscript
reviews
proposed
that
maintain
BC
cell
dormancy
microenvironment
discusses
supporting
specific
recurrence.
It
addresses
well-described
secretory
senescence,
inflammation,
aging,
adipogenic
conversion,
autophagy,
effects
trauma
surgery,
sympathetic
signaling,
transient
angiogenic
bursts,
hypercoagulable
states,
osteoclast
activation,
epigenetic
modifications
cells.
review
approaches
either
eliminating
micrometastases
or
maintaining
state.
Язык: Английский