Engineered Nanozymes with Asymmetric Mn─O─Ce Sites for Intratumorally Leveraged Multimode Therapy DOI

Ye Jin,

Chunsheng Li, Jiating Xu

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

Abstract Due to the enhanced flexibility of catalytic sites and synergistic effects between dual‐atom active centers, nanozymes stand out in tumor therapy. However, precisely regulating d‐band centers diatomic break linear‐scaling relationship intermediates remains a challenge. Herein, hydrothermally mass‐produced oxygen vacancies‐engineered bimetallic silicate bio‐nanoplatform with highly asymmetric O‐bridged cerium─manganese (Ce─Mn) (CeMn‐V DAs/EGCG@HA) is meticulously constructed by loading epigallocatechin‐3‐gallate (EGCG) modifying hyaluronic acid (HA) for multimodal cancer Theoretical calculations reveal that introduction Ce serves as secondary upshifts center Mn sites, thereby optimizing adsorption/desorption intermediates. The Mn─O─Ce moiety facilitates electron transport within CeMn‐V DAs, significantly enhancing peroxidase‐like activities ( K m = 27.7 mM V max 3.21×10 ─7 M s ─1 ). Upon 650 nm laser irradiation, DAs/EGCG inhibits heat shock protein expression, enabling mild‐photothermal η 36.1%) therapy, which can productively inhibit growth vivo, an inhibition rate up 96.2%. ligand‐field effect EGCG‐Mn/Ce complexes, high‐valent metal ions are effectively reduced, sustaining intrinsic self‐driven cocatalytic cycle reaction. Overall, construction bridged will further promote deep integration nanotechnology biology.

Язык: Английский

Engineered Nanozymes with Asymmetric Mn─O─Ce Sites for Intratumorally Leveraged Multimode Therapy DOI

Ye Jin,

Chunsheng Li, Jiating Xu

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

Abstract Due to the enhanced flexibility of catalytic sites and synergistic effects between dual‐atom active centers, nanozymes stand out in tumor therapy. However, precisely regulating d‐band centers diatomic break linear‐scaling relationship intermediates remains a challenge. Herein, hydrothermally mass‐produced oxygen vacancies‐engineered bimetallic silicate bio‐nanoplatform with highly asymmetric O‐bridged cerium─manganese (Ce─Mn) (CeMn‐V DAs/EGCG@HA) is meticulously constructed by loading epigallocatechin‐3‐gallate (EGCG) modifying hyaluronic acid (HA) for multimodal cancer Theoretical calculations reveal that introduction Ce serves as secondary upshifts center Mn sites, thereby optimizing adsorption/desorption intermediates. The Mn─O─Ce moiety facilitates electron transport within CeMn‐V DAs, significantly enhancing peroxidase‐like activities ( K m = 27.7 mM V max 3.21×10 ─7 M s ─1 ). Upon 650 nm laser irradiation, DAs/EGCG inhibits heat shock protein expression, enabling mild‐photothermal η 36.1%) therapy, which can productively inhibit growth vivo, an inhibition rate up 96.2%. ligand‐field effect EGCG‐Mn/Ce complexes, high‐valent metal ions are effectively reduced, sustaining intrinsic self‐driven cocatalytic cycle reaction. Overall, construction bridged will further promote deep integration nanotechnology biology.

Язык: Английский

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